CROHN'S DISEASE

This study looked at the long-term safety of the drug vedolizumab in 59 children (ages 2-17) with ulcerative colitis or Crohn's disease. The main goal was to track any side effects that occurred during treatment. The study found that vedolizumab was generally safe for long-term u…

This study looked at 100 children (ages 6-18) with Crohn's disease who were in remission after initial nutrition therapy. It compared two maintenance approaches: a cyclic diet providing all daily calories for a period, versus a daily supplement providing 25% of calories. The goal…

This study checked whether patients with rheumatoid arthritis, spondyloarthritis, Crohn's disease, or uveitis could safely switch from the original drug Remicade to its lower-cost biosimilar Inflectra. Researchers followed 262 adults at one hospital who had already received at le…

This study looked at how well the drug Humira works and how safe it is for people with moderate to severe Crohn's disease in China. About 156 participants took Humira as prescribed by their doctor and were followed for one year. The main goal was to track serious side effects and…

This study tested whether infusions of adult stem cells (PROCHYMAL) could help people with moderate-to-severe Crohn's disease who did not get better with standard treatments. About 330 adults received four intravenous doses over two weeks. The main goal was to achieve disease rem…

This study looked at whether the drug vedolizumab can help adults with moderate to severe Crohn's disease achieve complete remission—meaning no symptoms, normal blood and stool tests, and healed bowel walls seen on ultrasound. 72 participants were treated with vedolizumab as part…

This study looked at how safe and effective the drug upadacitinib (RINVOQ) is for Korean adults with moderate to severe ulcerative colitis or Crohn's disease. About 105 patients took the drug as prescribed by their doctor and were followed for up to 52 weeks. The main goal was to…

This study tested whether a web-based telemonitoring system (TECCU) helps people with moderate-to-severe inflammatory bowel disease (Crohn's disease or ulcerative colitis) stay in remission longer than standard care. 290 adults who needed immunosuppressants or biologics were foll…

This study tested whether infusions of special stem cells (PROCHYMAL) could help people with moderate-to-severe Crohn's disease who had already improved with an earlier stem cell treatment. The goal was to see how long the benefit lasts and if a repeat infusion can bring back imp…

This study looked at the safety of giving PROCHYMAL (a stem cell therapy) again to 73 adults with moderate-to-severe Crohn's disease that did not get better with standard treatments. Participants had already received PROCHYMAL in a previous study. The goal was to see if retreatme…

This study looked at whether a higher dose (10 mg/kg) of the drug TA-650 (also known as infliximab) could help people with Crohn's disease who were not getting enough benefit from the standard dose. The 39 participants received the higher dose every 8 weeks, and researchers track…

This study looked at nearly 24,000 older adults (65+) with ulcerative colitis or Crohn's disease to compare infection risks from three types of advanced treatments: ENTYVIO, TNF-alpha inhibitors, and ustekinumab. Researchers used existing Medicare claims data from 2016 to 2025 to…

This study reviewed medical records of 669 Crohn's disease patients to see if finding anal fistulas early—before symptoms appear—leads to better outcomes. Researchers compared patients whose fistulas were found by routine MRI (no symptoms) to those who already had symptoms. The g…

This study looked at whether regularly measuring the amount of anti-TNF medication and antibodies in the blood helps doctors make better treatment decisions for people with Crohn's disease or ulcerative colitis. 260 patients were split into two groups: one where doctors had acces…

This study looked at gut bacteria in 214 people with Crohn's disease, comparing those diagnosed as children (under 17) with those diagnosed after age 40. Researchers wanted to see if the bacteria differ by age and if those differences are linked to genetics. The goal is to better…

This study looked at whether measuring certain antibodies (ASCA) from gut biopsies can help understand Crohn's disease better than standard blood tests. Researchers compared 80 people with Crohn's, 40 with ulcerative colitis, and 40 without inflammatory bowel disease. The goal wa…

This study followed 165 people with inflammatory bowel disease (IBD) in Poland who were already taking or starting vedolizumab. Researchers simply observed whether patients chose intravenous (IV) or subcutaneous (SC) treatment, and how long they stayed on it. No new treatments or…