CROHN'S DISEASE

This early-stage study tests a new drug called zasocitinib (TAK-279) in 20 adults with active Crohn's disease who have not responded to other treatments. The main goal is to see if the drug is safe and how it affects inflammation in the gut. Participants will take the drug for 12…

This phase 2 trial tests whether an experimental oral tablet called H021 can help people with moderate to severe Crohn's disease. Participants receive either a low or high dose of H021 or a placebo for 12 weeks, with an option to continue treatment. The study measures symptom imp…

This study will test the drug Tabellvi (adalimumab) in 50 Chinese adults with moderate to severe Crohn's disease. The goal is to see how safe and effective it is in real-world settings, focusing on side effects and whether patients achieve remission after 26 weeks. Participants m…

This study tests a new treatment called DB-3Q for people with Crohn's disease that hasn't improved with standard therapies. DB-3Q is made from stem cells and may help reduce inflammation in the gut. The trial will enroll 36 adults and focus on safety and how well the treatment wo…

This study observes 35 adults with moderate-to-severe Crohn's disease or ulcerative colitis to see how long they continue taking guselkumab in everyday medical practice. Researchers will track treatment persistence and early symptom relief, like reduced bowel urgency. No experime…

This study tests whether adding palmitoleic acid (a natural fatty acid) to the standard drug infliximab helps heal the gut lining better than infliximab alone in people with Crohn's disease. About 400 adults with active Crohn's will take part. The main goal is to see if the combi…

This study tests two online pain education programs for adults with Crohn's disease or ulcerative colitis who have chronic pain. Participants will complete a 2-hour online session and report their pain and quality of life weekly for 8 weeks. The goal is to see if these programs a…

This study tests a mobile app designed to help Black and Hispanic adults with inflammatory bowel disease (IBD) manage stress and improve their quality of life. The app teaches coping skills, mindfulness, and disease acceptance. Researchers want to see if the app is practical and …

This study explores whether physical activity and fitness can reduce inflammation and improve quality of life in children aged 6 to 17 with Crohn's disease or ulcerative colitis. Researchers will track 100 participants over time and test a 12-week supervised exercise program. The…

This study will test a one-day acceptance and commitment therapy (ACT) program for 50 veterans who have both inflammatory bowel disease (IBD) and a mental health condition like depression, anxiety, or PTSD. The goal is to see if this brief therapy can improve their quality of lif…

This study will follow 100 adults with Crohn's disease, ulcerative colitis, or other IBD, plus their healthy relatives, for up to 3 years. Researchers will collect blood, stool, tissue samples, and imaging to track how immune cells and genetics change over time. The goal is to fi…

This study looked at nearly 24,000 older adults (65+) with ulcerative colitis or Crohn's disease to see if certain advanced treatments lead to more infections. Researchers compared patients taking ENTYVIO, TNF-alpha inhibitors, or ustekinumab using Medicare claims data from 2016 …

This study will look at whether tiny plastic particles found in food and water are linked to Crohn's disease. Researchers will compare 90 people—some with Crohn's and some without—to see if those with Crohn's have more plastic particles in their blood and gut, and how that affect…

This study looks at whether using a device that helps see veins under the skin can make placing an IV in children faster and with fewer needle sticks. About 500 children under 18 who need an IV for day surgery or other procedures will take part. Researchers will compare the time …