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Could Two-Drug cocktails tame stubborn inflammatory bowel disease?

NCT ID NCT07697456

Not yet recruiting Disease control Sponsor: AbbVie Source: ClinicalTrials.gov ↗

First seen Jul 13, 2026 · Last updated Jul 14, 2026 · Updated 1 time

Summary

This study tests whether combining risankizumab with either trosunilimab or ABBV-701 can safely reduce inflammation and improve symptoms in adults with moderately to severely active Crohn's disease or ulcerative colitis. Participants are randomly assigned to one of the combination treatments or a placebo. The goal is to see if these advanced therapies can achieve endoscopic remission, meaning the gut lining heals.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
risankizumab, trosunilimab, and ABBV-701
What this could lead to
If successful, these combination therapies could offer new treatment options for people with hard-to-control inflammatory bowel disease.
What could go wrong
This is an early-phase trial with a limited number of participants per arm, so results may not apply to everyone. Side effects are possible, and the combinations may not prove more effective than existing treatments.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Crohn disease ulcerative colitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CROHN'S DISEASE ULCERATIVE COLITIS

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • AZ-Delta. /ID# 281031

    Roeselare, West-Vlaanderen, 8800, Belgium

  • Auzmer Research /ID# 280786

    Lakeland, Florida, 33813, United States

  • CHU de Liege /ID# 281182

    Liège, 4000, Belgium

  • Chris Hani Baragwanath Hospital /ID# 284122

    Johannesburg, Gauteng, 1864, South Africa

  • Chu De Charleroi - Hopital Civil Marie Curie /ID# 281632

    Lodelinsart, Hainaut, 6042, Belgium

  • Digestive Disease Consultants - Brunswick /ID# 283935

    Brunswick, Ohio, 44212, United States

  • Excellentis Clinical Trial Consultants /ID# 282430

    George, Western Cape, 6529, South Africa

  • Gastro Health - Miami /ID# 282001

    Miami, Florida, 33176, United States

  • Gi Alliance - Texas Digestive Disease Consultants - San Marcos /ID# 283947

    San Marcos, Texas, 78666, United States

  • Gold Coast Hospital /ID# 282434

    Southport, Queensland, 4215, Australia

  • Hackensack Meridian Health - Hackensack University Medical Center /ID# 281865

    Hackensack, New Jersey, 07601, United States

  • Hospital Galdakao-Usansolo /ID# 280388

    Galdakao, Vizcaya, 48960, Spain

  • Hospital Rio Hortega /ID# 281426

    Valladolid, 47012, Spain

  • Hospital Universitario Reina Sofia /ID# 281446

    Córdoba, 14004, Spain

  • Iwate Medical University Hospital /ID# 282387

    Shiwa-gun, Iwate, 028-3695, Japan

  • John Hunter Hospital /ID# 282537

    Newcastle, New South Wales, 2305, Australia

  • Lenasia Clinical Trial Centre - Johannesburg /ID# 281415

    Johannesburg, Gauteng, 1821, South Africa

  • Macquarie Hospital /ID# 281739

    Macquarie University, New South Wales, 02109, Australia

  • Mater Hospital Brisbane /ID# 281738

    South Brisbane, Queensland, 4101, Australia

  • Monash Health - Monash Medical Centre - Clayton /ID# 281711

    Clayton, Victoria, 3168, Australia

  • Portland Gastroenterology Center - Portland - Congress Street /ID# 281970

    Portland, Maine, 04102, United States

  • Queens Village Primary Medical Center /ID# 281857

    New York, New York, 11428, United States

  • Skyline Gastroenterology of West Tennessee /ID# 284146

    Jackson, Tennessee, 38301, United States

  • Takagi Clinic - Sendai /ID# 281805

    Sendai, Miyagi, 981-3213, Japan

  • Texas Digestive Disease Consultants /ID# 284159

    Austin, Texas, 78731, United States

  • Universitaetsklinikum Tuebingen /ID# 282958

    Tübingen, Baden-Wurttemberg, 72076, Germany

  • Universitair Ziekenhuis Antwerpen /ID# 282218

    Edegem, Antwerpen, 2650, Belgium

  • Universite Catholique de Louvain-Namur - Centre Hospitalier Universitaire Dinant /ID# 281312

    Yvoir, Namur, 5530, Belgium

  • University Hospital Zurich /ID# 280548

    Zurich, Canton of Zurich, 8091, Switzerland

  • University Medical Centre Maribor /ID# 281175

    Maribor, 2000, Slovenia

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