ULCERATIVE COLITIS

This program provides eligible patients with access to the drug upadacitinib for conditions like Crohn's disease, ulcerative colitis, and atopic dermatitis before it is officially approved in their country. A doctor must determine if the potential benefits for an individual patie…

This study is testing whether adding a weight-loss drug (tirzepatide) to a standard ulcerative colitis drug (mirikizumab) works better than the colitis drug alone. It's for adults who have active ulcerative colitis and are also overweight or have obesity. The main goals are to se…

This large, late-stage study is testing an investigational drug called duvakitug for people with moderate-to-severe ulcerative colitis, a chronic inflammatory bowel disease. The goal is to see if the drug can help patients achieve clinical remission—meaning a major reduction in s…

This study is testing whether a supplement called nicotinamide riboside, a form of vitamin B3, can help control ulcerative colitis in children and teenagers. Researchers want to see if the supplement improves how energy-producing parts of gut cells work. The study will enroll 40 …

This study is testing whether budesonide extended-release tablets can help children aged 5-17 with mild to moderate ulcerative colitis achieve remission. Participants will take either the study medication or a placebo for 8 weeks while continuing their current background medicati…

This study is testing whether an experimental drug called tilpisertib fosmecarbil (GS-5290) can help control symptoms of moderate to severe ulcerative colitis. About 176 adults who haven't responded well to other treatments will receive either the drug or a placebo for 12 weeks. …

This study is testing whether breathing pure oxygen in a pressurized chamber helps people hospitalized with severe ulcerative colitis flare-ups. Researchers want to see if this therapy can quickly reduce symptoms like bleeding and diarrhea, and help patients avoid needing stronge…

This study is testing whether adding a new drug called LY4268989 to an existing UC treatment (mirikizumab) works better than the existing drug alone. It's for adults with moderate to severe ulcerative colitis who haven't gotten enough relief from other standard medications. The m…

This study is testing whether a new oral medication called TAK-279 can reduce inflammation and symptoms in adults with moderate to severe ulcerative colitis. For the first 12 weeks, participants will be randomly assigned to receive either TAK-279 or a placebo pill, and then all p…

This study is testing whether a specially designed anti-inflammatory diet featuring common American foods like sandwiches, grilled meats, and smoothies can help put ulcerative colitis into remission. Researchers will enroll 122 American patients with active ulcerative colitis to …

This study is testing how well and how safely the drug filgotinib works for Korean adults with moderate to severe ulcerative colitis, a chronic inflammatory bowel disease. It is for people whose symptoms have not been controlled well by standard medications like steroids or other…

This study is observing how well the approved drug risankizumab works for adults with moderate to severe ulcerative colitis in real-world medical settings in Japan. It will follow about 200 patients for up to 3 years as they receive the drug as part of their normal care. The main…

This early-stage study is testing the safety and effects of an oral probiotic called R-3750 in adults with mild to moderate ulcerative colitis. Researchers will monitor side effects and check if the probiotic reduces bowel inflammation and improves symptoms. The goal is to see if…

This study is testing two new drugs, eltrekibart and mirikizumab, alone and together, for adults with moderate to severe ulcerative colitis. The goal is to see if these treatments can safely bring the disease under control and help patients achieve remission. It is for people who…

This study is testing whether adding mebendazole, a medication typically used for parasitic worm infections, helps people with mild-to-moderate ulcerative colitis who are already taking standard mesalamine treatment. Researchers will compare two groups of 23 patients each over si…

This study is testing whether adding fermented foods like yogurt, kefir, and kimchi to the diet can help control inflammation and improve quality of life for adults with mild to moderate ulcerative colitis. Researchers at Stanford University are enrolling 21 participants to see i…

This study is testing a new drug called RO7837195 for adults with moderate to severe ulcerative colitis who haven't gotten better with other treatments. It aims to see if the drug can reduce symptoms and gut inflammation better than a placebo. The trial includes an initial 12-wee…

This study is testing a new oral drug called BRS201 for adults experiencing a severe flare-up of ulcerative colitis who haven't gotten better with steroid treatment. Over 12 weeks, participants will take the study drug for 4 weeks and have several clinic visits for check-ups and …

This study is testing whether taking frozen capsules containing processed stool from healthy donors can help control active ulcerative colitis. It will involve 129 adults whose current treatments aren't working well. Participants will receive either the full stool transplant, a f…

This study is testing the safety and effects of the immunotherapy drug nivolumab in people who have both advanced cancer and an autoimmune disease like lupus, rheumatoid arthritis, or Crohn's disease. It will enroll 300 adults to see if the drug can help control their cancer whil…

This study is testing a drug called mirikizumab to see if it can help control ulcerative colitis in children and teenagers aged 2 to 18. It is for kids whose disease is moderate to severe and who haven't gotten enough help from other standard treatments. The main goal is to see i…

This study is observing how well the drug tofacitinib works for people with ulcerative colitis in everyday Swedish healthcare. It will track about 120 adult patients who are already prescribed this medication by their doctor to see if it reduces their gut inflammation and symptom…

This program provides continued access to an investigational drug called vedolizumab for children and teenagers with moderate to severe ulcerative colitis or Crohn's disease. It's for participants who completed a previous clinical trial and are still benefiting from the treatment…

This study follows 200 adults with moderate to severe ulcerative colitis in Germany and Austria who are already prescribed the medication risankizumab by their doctors. Researchers will track how well the drug controls symptoms like bowel frequency and rectal bleeding over one ye…

This study is monitoring the safety and real-world effectiveness of vedolizumab injections in 600 Korean adults with ulcerative colitis or Crohn's disease. Participants have already tried other treatments without success and are receiving vedolizumab as part of their regular care…

This study is testing an investigational drug called SAR442970 to see if it can help control ulcerative colitis. It will involve about 99 adults with moderate to severe disease who haven't responded well to other treatments. The main goal is to see if the drug leads to clinical r…

This study is testing if adding a common allergy medicine, desloratadine, to standard ulcerative colitis treatment helps patients feel better. It will involve 44 adults with mild-to-moderate disease who are already taking mesalamine. Researchers want to see if the drug reduces gu…

This study is testing whether rupatadine, a medication, can help control ulcerative colitis symptoms and reduce inflammation. Researchers will enroll 60 adults with mild-to-moderate ulcerative colitis to evaluate safety and effectiveness. The goal is to see if this treatment can …

This study is testing several long-acting antibody treatments, both alone and in combinations, for adults with moderate to severe ulcerative colitis. The goal is to see if these treatments can control the disease by reducing inflammation and symptoms. The trial will involve 645 p…

This study is testing a daily pill called etrasimod to see if it can help control the symptoms of moderate to severe ulcerative colitis in teenagers. It will involve about 36 participants aged 12 to 18 and will last for one year, with an option to continue for up to five years. T…

This study is testing whether robotic surgery can be used effectively for people with inflammatory bowel diseases like Crohn's and ulcerative colitis. Researchers will compare robotic surgery to standard laparoscopic (keyhole) surgery in 100 patients to see which approach works b…

This study is testing an experimental oral medication called ISM5411 for adults with active ulcerative colitis. The drug is designed to work mainly in the gut to help protect the intestinal lining and reduce inflammation. Researchers will compare the drug to a placebo in 80 parti…

This study is testing if adding a freeze-dried fecal microbiota transplant (FMT) to standard biologic medications helps people with active ulcerative colitis get better. It will involve 40 adults in Canada who are starting new treatment with either vedolizumab or ustekinumab. Par…

This study aims to see how well and how safely the drug mirikizumab works over a long period (about 3 years) in children and adolescents with moderate-to-severe ulcerative colitis or Crohn's disease. It is an extension study for about 150 young people who have already been taking…

This study is testing if a diet that removes common food additives (like carrageenan and polysorbates) can help people with moderately active ulcerative colitis. For one month, 70 participants will either follow this special diet or a standard healthy diet. Researchers will check…

This study is testing whether a minimally invasive stomach-reducing procedure can help obese patients with ulcerative colitis lose weight before they undergo major colon removal surgery. Researchers want to see if this approach is safe and effective for this specific group of pat…

This study aims to learn about the long-term safety of vedolizumab injections in children and teenagers with ulcerative colitis or Crohn's disease. About 70 participants who responded well to the treatment in a previous study will continue receiving injections for up to 2 years, …

This study is testing whether a medication called vedolizumab, given as an injection under the skin, can help control symptoms and achieve remission in people with moderate to severe ulcerative colitis or Crohn's disease. About 400 participants will receive the treatment for abou…

This study follows 400 adults in Germany, Austria, and Switzerland who are already prescribed upadacitinib (RINVOQ) by their doctor for moderate-to-severe ulcerative colitis. The goal is to see if patients who show improvement in their symptoms and gut inflammation after 8 weeks …

This study aims to check the long-term safety of an oral medication called zasocitinib (TAK-279) for adults with active Crohn's disease or ulcerative colitis. It is an extension for up to two years for people who benefited from the drug in earlier, shorter studies. The main goal …

This study aims to see if the medication risankizumab works better than vedolizumab for adults with moderate to severe ulcerative colitis who haven't tried similar advanced treatments. About 530 participants worldwide will be randomly assigned to receive one of the two approved d…

This study is testing whether a special diet that mimics the effects of fasting can help people with mild to moderate ulcerative colitis. Researchers want to see if this diet reduces gut inflammation and improves symptoms and quality of life. About 75 participants will follow the…

This study is testing a medication called filgotinib to see if it can help children and teenagers (ages 8 to 18) with moderate to severe ulcerative colitis. The main goals are to see if the drug can reduce symptoms, help patients achieve remission, and keep the disease under cont…

This large, late-stage study is testing whether an investigational drug called duvakitug can help people with moderate-to-severe ulcerative colitis stay in remission. About 671 participants who responded to initial treatment will receive either duvakitug or a placebo for 40 weeks…

This study is testing whether taking prebiotic supplements for 8 weeks can improve the mix of gut bacteria and help control symptoms in people with ulcerative colitis. Researchers will enroll 70 adults with active symptoms and track changes in their gut health and inflammation ov…

This study follows 80 Chinese adults with moderate to severe ulcerative colitis who are already prescribed the drug upadacitinib by their doctor. The goal is to see how well the medication works in real-world use over one year. Researchers will collect routine health data from re…

This study is testing a medication called risankizumab in children and teenagers (ages 2 to 18) who have moderate to severe ulcerative colitis, a chronic inflammatory bowel disease. The main goals are to find the right dose for children, see how well it controls the disease, and …

This study is testing a gentle nerve stimulation treatment for adults with ulcerative colitis whose symptoms haven't improved enough with standard medications. It aims to see if stimulating nerves near the tailbone is safe and can reduce gut inflammation and symptoms over a year.…

This study is testing whether taking capsules containing processed stool from a healthy donor can help people newly diagnosed with certain inflammatory diseases like rheumatoid arthritis, Crohn's disease, or ulcerative colitis. About 200 participants will receive either these spe…

This study is testing whether a smartphone app that automatically tracks health data can help people with active Crohn's disease or ulcerative colitis. It aims to see if this remote monitoring helps patients stay in remission longer and reduces hospital visits compared to standar…

This study is testing a new under-the-skin injection form of the drug vedolizumab for children and teenagers with moderate to severe ulcerative colitis or Crohn's disease. About 70 participants who have already responded to the standard IV treatment will receive the injection for…

This study is testing whether starting treatment with two drugs together (vedolizumab and tofacitinib) is effective for adults with moderate to severe ulcerative colitis who haven't gotten enough relief from previous biologic treatments. About 65 participants will receive both dr…

This study asks cancer patients which way they prefer to receive their immunotherapy drugs: as a quick injection under the skin or through a longer IV infusion. Researchers will enroll 480 people with various advanced cancers to compare comfort, convenience, and quality of life b…

This study aims to understand how inflammatory bowel diseases (IBD) like Crohn's and colitis begin and progress, long before a person feels sick. Researchers will follow 450 adults for 10 years, focusing on those whose IBD was found during a routine colonoscopy before they had an…

This study aims to discover new targets for future autoimmune disease treatments by analyzing tissue and blood samples. Researchers will collect samples from 300 adults with conditions like Crohn's disease, multiple sclerosis, or ulcerative colitis during periods of active inflam…

This study aims to find better ways to detect bowel scarring (fibrosis) in people with ulcerative colitis. Researchers will test if special ultrasound scans can accurately measure this scarring by comparing scan results to actual tissue samples taken during routine colonoscopies.…

This study aims to understand how doctors around the world use a specific treatment strategy for Crohn's Disease and Ulcerative Colitis, and whether using this strategy leads to better results for patients. It will look back at the medical records of 2,000 adults who have had the…

This study aims to learn how the body's immune system causes inflammation in the gut of people with Crohn's disease and ulcerative colitis. Researchers will observe up to 1,000 patients and collect blood and tissue samples to understand the disease better. The study does not test…

This study aims to understand how a patient's nutritional status and body composition affect their treatment outcomes for Crohn's disease and ulcerative colitis. Researchers will observe 300 patients starting new medications or having surgery, measuring things like muscle mass an…

This study aims to find out if changes in sleep quality can serve as an early warning sign for flare-ups in people with Crohn's disease or ulcerative colitis. Researchers will monitor 216 patients who are currently in remission, tracking their sleep patterns with wrist-worn devic…

This study aims to understand how inflammatory bowel disease (IBD) like Crohn's and colitis affects pregnancy, and how pregnancy affects IBD. Researchers will review health records of 945 women with IBD who have been pregnant. The main goal is to count how often IBD symptoms flar…

This study aims to understand how having Crohn's disease or ulcerative colitis as a child affects a person's job prospects and education level as an adult. Researchers will survey 460 adults who were diagnosed as children and compare their career and education outcomes to the gen…

This study is testing an educational tool designed to help melanoma patients who also have autoimmune diseases (like rheumatoid arthritis or Crohn's disease) understand their treatment options with immune checkpoint inhibitor drugs. Researchers want to see if the tool is easy to …