Could vitamin B3 tame gut inflammation?
NCT ID NCT06488625
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a special form of vitamin B3 (nicotinamide) that releases in the lower gut to treat mild to moderate ulcerative colitis. About 459 adults will receive either a low or high dose of the vitamin or a placebo. The goal is to see if it can reduce symptoms and improve gut health without serious side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- nicotinamide (vitamin B3) in a special capsule that releases it in the lower gut
- What this could lead to
- If it works, this could offer a new, well-tolerated treatment option for people with mild to moderate ulcerative colitis.
- What could go wrong
- This is an early-to-mid stage trial, so the treatment may not prove effective or safe. Results may not apply to all patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
Locations
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Agaplesion Frankfurter Diakonie Kliniken gGmbH
RECRUITINGFrankfurt am Main, 60431, Germany
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Charite Universitaetsmedizin Berlin KöR
RECRUITINGBerlin, 10117, Germany
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Charite Universitaetsmedizin Berlin KöR
RECRUITINGBerlin, 12203, Germany
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DRK Kliniken Berlin
RECRUITINGBerlin, 12559, Germany
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Evangelisches Krankenhaus Kalk gGmbH
RECRUITINGCologne, 51103, Germany
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Gastroenterologie am Herrengarten
RECRUITINGDarmstadt, 64293, Germany
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Gastroenterologische Schwerpunktpraxis Prof. Dr. Ludwig & Dr. med. Güthle
RECRUITINGDornstadt, 89160, Germany
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Gastropraxis Magdeburg
RECRUITINGMagdeburg, 39104, Germany
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Gastropraxis an der St. Barbara-Klinik
RECRUITINGHamm, 59073, Germany
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Gesundheit Nord gGmbH Klinikverbund Bremen
RECRUITINGBremen, 28205, Germany
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Goethe University Frankfurt
RECRUITINGFrankfurt, 60590, Germany
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Martin-Luther-Universitaet Halle-Wittenberg
RECRUITINGHalle, 06120, Germany
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Medical Care Unit Dachau
WITHDRAWNDachau, 85221, Germany
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Practice for Gastroenterology
RECRUITINGHanover, 30449, Germany
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Private Practice for Gastroenterology
RECRUITINGHeidelberg, 69115, Germany
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Sozialstiftung Bamberg
RECRUITINGBamberg, 96049, Germany
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St. Marien Und St. Annastiftskrankenhaus
RECRUITINGLudwigshafen, 67067, Germany
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Universitaet Muenster
NOT_YET_RECRUITINGMünster, 48149, Germany
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Universitaetsklinikum Aachen AöR
NOT_YET_RECRUITINGAachen, 52074, Germany
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Universitaetsklinikum Augsburg
RECRUITINGAugsburg, 86156, Germany
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Universitaetsklinikum Carl Gustav Carus Dresden an der Technischen Universitaet Dresden AöR
RECRUITINGDresden, 01307, Germany
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Universitaetsklinikum Schleswig-Holstein AöR
RECRUITINGKiel, Schleswig-Holstein, 24105, Germany
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Universitaetsklinikum Schleswig-Holstein AöR
RECRUITINGLübeck, 23538, Germany
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Universitaetsklinikum Ulm AöR
RECRUITINGUlm, 89081, Germany
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Universitat Heidelberg
RECRUITINGMannheim, 68167, Germany
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University Medical Center Hamburg-Eppendorf
NOT_YET_RECRUITINGHamburg, 20246, Germany
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