New drug trial aims to tame gut disease in kids

NCT ID NCT06865417

Recruiting now Disease control Sponsor: Alfasigma S.p.A. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 13, 2026 · Updated 2 times

Summary

This study tests a daily pill called filgotinib in 80 children aged 8 to 17 with moderate to severe ulcerative colitis, a chronic gut disease. The goal is to see if the drug can reduce inflammation and help children feel better. All participants receive the drug, and the study tracks remission rates and side effects over time.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: filgotinib (a drug taken as a tablet once daily)
What this could lead to: If successful, this could provide a new treatment option for children with ulcerative colitis that helps control the disease and reduce symptoms.
What could go wrong: This is a single-arm study with no placebo group, so results may be less definitive. The drug may cause side effects, and not all children may respond.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

ulcerative colitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ULCERATIVE COLITIS

Contacts and locations

Locations

ASST Fatebenefratelli Sacco
RECRUITING

Milan, Italy, 20154, Italy
Alder Hey Children's Hospital
RECRUITING

Liverpool, United Kingdom
Association Hospitaliere De Bruxelles Hopital Universitaire Des Enfants Reine Fabiola
NOT_YET_RECRUITING

Brussels, Brussels Capital, 1020, Belgium
Athens General Children's Hospital Panagioti And Aglaia Kyriakou
NOT_YET_RECRUITING

Athens, Greece, 11527, Greece
Azienda Ospedaliera Universitaria Federico II Di Napoli
RECRUITING

Naples, Italy, 80131, Italy
Azienda Ospedaliero Universitaria dell Marche I G M Lancisi G Salesi
RECRUITING

Ancona, Italy, 60123, Italy
Azienda Ospedaliero-Universitaria Policlinico Umberto I
RECRUITING

Rome, Italy, 00161, Italy
Azienda Ospedaliero-Universitaria Ss Antonio E Biagio E Cesare Arrigo
RECRUITING

Alessandria, Italy, 15121, Italy
Bristol Royal Infirmary
RECRUITING

Bristol, BS2 8HW, United Kingdom
CCAB Centro Clinico Academico Braga Associacao
RECRUITING

Braga, Portugal, 4710-243, Portugal
CHU de Montpellier
RECRUITING

Montpellier, France, 34295, France
Centre Hospitalier Regional De La Citadelle
NOT_YET_RECRUITING

Liège, Liege, 4000, Belgium
Centre Hospitalier Regional Universitaire De Tours
RECRUITING

Tours, France, 37000, France
Centre Hospitalier Universitaire De Dijon
RECRUITING

Dijon, France, 21000, France
Centre Hospitalier Universitaire De Rennes
RECRUITING

Rennes, France, 35200, France
Centre Hospitalier Universitaire Dinant Godinne Sainte-Elisabeth-UCL-Namur
RECRUITING

Namur, Namur, 5000, Belgium
Chelsea and Westminster Hospital
NOT_YET_RECRUITING

London, SW10 9NH, United Kingdom
Children's Health Ireland
NOT_YET_RECRUITING

Dublin, Ireland, D12 PN40, Ireland
Children's Hospital Zagreb
RECRUITING

Zagreb, Croatia, 10000, Croatia
Dr. Victor Gomoiu Clinical Children Hospital
RECRUITING

Bucharest, Romania, 022102, Romania
Gabinet Lekarski Bartosz Korczowski
RECRUITING

Rzeszów, Poland, 35-302, Poland
General Hospital Of Thessaloniki Papageorgiou
RECRUITING

Efkarpia, Greece, 56429, Greece
Hippokration Hospital
RECRUITING

Thessaloniki, Greece, 54642, Greece
Hopital Saint Vincent de Paul - GHICL Lille
RECRUITING

Lille, France, 59020, France
Hospital Femme Mere Enfant
RECRUITING

Bron, France, 69500, France
Hospital Germans Trias I Pujol
RECRUITING

Badalona, Spain, 08916, Spain
Hospital Pediátrico de Coimbra
RECRUITING

Coimbra, Portugal, 3000-602, Portugal
Hospital Universitario Reina Sofia
RECRUITING

Córdoba, Spain, Spain
IRCCS Materno Infantile Burlo Garofolo
RECRUITING

Trieste, Italy, 34137, Italy
In Vivo Sp. z o.o.
RECRUITING

Bydgoszcz, Poland, 85-048, Poland
Instytut Centrum Zdrowia Matki Polki
RECRUITING

Lodz, Poland, 93-338, Poland
Instytut Pomnik Centrum Zdrowia Dziecka
RECRUITING

Warsaw, Poland, 04-730, Poland
Klinicki Bolnicki Centar Osijek
RECRUITING

Osijek, Croatia, 31000, Croatia
Ninewells Hospital
RECRUITING

Glasgow, G51 4TF, United Kingdom
Oslo University Hospital HF
RECRUITING

Oslo, Norway, 0372, Norway
Ospedale Pediatrico Bambino Gesu
RECRUITING

Rome, Italy, 00165, Italy
Sheffield Children's Hospital
RECRUITING

Sheffield, S10 2TH, United Kingdom
Spitalul Clinic De Urgenta Pentru Copii Louis Turcanu Timisoara
RECRUITING

Timișoara, Romania, 300011, Romania
Sykehuset I Vestfold HF
RECRUITING

Tønsberg, Norway, 3116, Norway
The Newcastle upon Tyne Hospital FT
NOT_YET_RECRUITING

Newcastle, NE1 4LP, United Kingdom
Unidade Local De Saude Do Alto Minho E.P.E.
RECRUITING

Viana do Castelo, Portugal, 4904-858, Portugal
Universitaetsklinikum Aachen AöR
RECRUITING

Aachen, Germany, 52074, Germany
Universitaetsklinikum Leipzig AöR
RECRUITING

Leipzig, Germany, 04103, Germany
Universitaetsklinikum Tuebingen AöR
RECRUITING

Tübingen, Germany, 72076, Germany
Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz KöR
RECRUITING

Mainz, Germany, 55131, Germany
University General Hospital Attikon
RECRUITING

Athens, Greece, 12462, Greece
University Hospital Centre Zagreb
RECRUITING

Zagreb, Croatia, 10000, Croatia

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