New combo pill aims to tame stubborn ulcerative colitis

NCT ID NCT07186101

Recruiting now Disease control Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 07, 2026 · Updated 6 times

Summary

This study tests whether adding a new oral drug, LY4268989, to the existing treatment mirikizumab works better than mirikizumab alone for adults with moderate-to-severe ulcerative colitis. About 252 participants will receive either the combination or mirikizumab plus a placebo for up to 104 weeks. The main goal is to see if more people achieve remission with the combination.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: LY4268989 (also called MORF-057 or zotemtegrast) and mirikizumab
What this could lead to: If successful, this combination could offer a more effective treatment option for people with moderate-to-severe ulcerative colitis, potentially improving remission rates.
What could go wrong: This is a Phase 2 trial, so it is still early. The combination may not work better than mirikizumab alone, and side effects are possible. Results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

ulcerative colitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ULCERATIVE COLITIS

Contacts and locations

Locations

ASST Grande Ospedale Metropolitano Niguarda
NOT_YET_RECRUITING

Milan, 20162, Italy
Aalborg Universitetshospital, Syd
RECRUITING

Gistrup, 9260, Denmark
Adana City Hospital
NOT_YET_RECRUITING

Adana, Turkey (Türkiye)
All India Institute of Medical Sciences
NOT_YET_RECRUITING

New Delhi, 110029, India
Alliance Medical Research
RECRUITING

Lighthouse PT, Florida, 33064, United States
Antalya Egitim ve Arastırma Hastanesi
NOT_YET_RECRUITING

Antalya, 07100, Turkey (Türkiye)
Ashwin Hospital
RECRUITING

Coimbatore, 641012, India
Atlantic Medical Research
RECRUITING

Margate, Florida, 33063, United States
BRA - Clínica Médica e Terapia Assistida
NOT_YET_RECRUITING

Tajaí, 88301-220, Brazil
Biopharma Informatic, LLC
RECRUITING

Los Angeles, California, 90035, United States
Boca Clinical Trials Mexico S.C.
NOT_YET_RECRUITING

Guadajalara, 44600, Mexico
Brigham and Women's Hospital
RECRUITING

Boston, Massachusetts, 02215, United States
Békés Megyei Központi Kórház Dr. Réthy Pál Tagkórház
RECRUITING

Békéscsaba, 5600, Hungary
C.I.C. Mauricie inc.
RECRUITING

Trois-Rivières, G8T 7A1, Canada
CAEP - Synvia Labs
RECRUITING

Campinas, 13087-567, Brazil
CPQuali Pesquisa Clínica
RECRUITING

São Paulo, 01228-000, Brazil
Care Access - Ogden
RECRUITING

Ogden, Utah, 84403, United States
Carilion Clinic
NOT_YET_RECRUITING

Roanoke, Virginia, 24014, United States
Center for Gastrointestinal Health - Fairview Heights
NOT_YET_RECRUITING

Belleville, Illinois, 62223, United States
Centro Digestivo de Curitiba
RECRUITING

Curitiba, 80430-180, Brazil
Centro Internacional de Pesquisa Clínica (CIPES)
RECRUITING

São José dos Campos, 12230-001, Brazil
Centro Médico Teknon
RECRUITING

Barcelona, 08022, Spain
Centro de Investigación Clinica Chapultepec
NOT_YET_RECRUITING

Mexico City, 04100, Mexico
Centro de Investigación y Gastroenterología - S.C.
RECRUITING

Mexico City, 03330, Mexico
Changzhou Second People's Hospital
RECRUITING

Changzhou, 213000, China
Charité Universitaetsmedizin Berlin - Campus Mitte
NOT_YET_RECRUITING

Berlin, 10117, Germany
Charlton Digestive Disease Centre
RECRUITING

Hamilton, L8N 1Y2, Canada
Chongqing General Hospital
RECRUITING

Chongqing, 401147, China
Chronos Pesquisa Clínica
RECRUITING

Brasília, 72145-450, Brazil
Clinexpert Gyöngyös
RECRUITING

Gyöngyös, 3200, Hungary
Clinica de Investigacion en Reumatologia y Obesidad S. C.
NOT_YET_RECRUITING

Guadalajara, 44650, Mexico
Clinical Research Institute S.C.
RECRUITING

Tlalnepantla, 54055, Mexico
Clinical Research Institute of Michigan, LLC
RECRUITING

Clinton Township, Michigan, 48038, United States
Clinical Research Partners, LLC
RECRUITING

Richmond, Virginia, 23226, United States
Clinical Research of Osceola
RECRUITING

Kissimmee, Florida, 34741, United States
Clinnova Research - Anaheim
RECRUITING

Anaheim, California, 92805, United States
Clínica Hepatogastro JK
RECRUITING

São Paulo, 04543-011, Brazil
Constanta County Emergency Clinical Hospital Sf.Ap.Andrei
RECRUITING

Constanța, 900591, Romania
Dayton Gastroenterology, LLC
RECRUITING

Dayton, Ohio, 45415, United States
Delta Health Care
RECRUITING

Bucharest, 014142, Romania
Dicle Üniversitesi
RECRUITING

Sur, 21200, Turkey (Türkiye)
Digestive Disease Medicine of Central New York
RECRUITING

Utica, New York, 13502, United States
Digestive and Liver Center of Florida
RECRUITING

Orlando, Florida, 32825, United States
ETG Zamość
RECRUITING

Zamość, 22-400, Poland
Elisabeth-TweeSteden Ziekenhuis
RECRUITING

Tilburg, 5022 GC, Netherlands
Encore Borland-Groover Clinical Research
RECRUITING

Jacksonville, Florida, 32256, United States
Eskisehir Osmangazi University
RECRUITING

Eskişehir, 26480, Turkey (Türkiye)
FAICIC S. de R.L. de C.V.
RECRUITING

Veracruz, 91900, Mexico
First Affiliated Hospital of Kunming Medical University
RECRUITING

Kunming, 650032, China
Florida Research Institute
RECRUITING

Lakewood Rch, Florida, 34211, United States
Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico
RECRUITING

Milan, 20122, Italy
Fondazione Policlinico Universitario Agostino Gemelli
RECRUITING

Roma, 00168, Italy
Fukuoka University Hospital
RECRUITING

Fukuoka, 814-0180, Japan
Fundação Universidade de Caxias do Sul (FUCS)
RECRUITING

Caxias do Sul, 95070-560, Brazil
GI Alliance - Dallas - Gaston Avenue
NOT_YET_RECRUITING

Dallas, Texas, 75246, United States
GI Alliance - Fort Worth
RECRUITING

Fort Worth, Texas, 76104, United States
GI Alliance - Garland
RECRUITING

Garland, Texas, 75044, United States
GI Alliance - Glenview
RECRUITING

Glenview, Illinois, 60026, United States
GI Alliance - Lubbock
RECRUITING

Lubbock, Texas, 79410, United States
GI Alliance - Richmond
RECRUITING

Richmond, Virginia, 23229, United States
GI Alliance-Webster
RECRUITING

Webster, Texas, 77598, United States
GI Associates - GIA and Endoscopy Center - Flowood
RECRUITING

Flowood, Mississippi, 39232, United States
Galileo Medical Research
RECRUITING

Juiz de Fora, 36033-318, Brazil
Gastro One - Walnut Run Road
RECRUITING

Cordova, Tennessee, 38018, United States
Gastroenterology Associates, P.A. of Greenville
RECRUITING

Greenville, South Carolina, 29607, United States
Gastroenterology Health Partners
RECRUITING

New Albany, Indiana, 47150, United States
Gastroenterology Health Partners
RECRUITING

Louisville, Kentucky, 40218, United States
Gazi University Health Research and Application Center Gazi Hospital
RECRUITING

Ankara, 06560, Turkey (Türkiye)
Gi Alliance - Gurnee
RECRUITING

Gurnee, Illinois, 60031, United States
Gokeikai Ofuna Chuo Hospital
RECRUITING

Kamakura, 247-0056, Japan
Gyncentrum sp. z o.o. NZOZ Holsamed - oddział Libero
RECRUITING

Katowice, 40-600, Poland
Herlev and Gentofte Hospital
RECRUITING

Copenhagen, 2730, Denmark
Hospital Ernesto Dornelles
RECRUITING

Porto Alegre, 90160-092, Brazil
Hospital Santa Catarina - Paulista
NOT_YET_RECRUITING

São Paulo, 01310-000, Brazil
Hospital Universitario La Paz
RECRUITING

Madrid, 28046, Spain
Hospital Universitario de Fuenlabrada
NOT_YET_RECRUITING

Fuenlabrada, 28942, Spain
Hospital de Cabueñes
RECRUITING

Gijón, 33394, Spain
Humanitas
NOT_YET_RECRUITING

Rozzano, 20089, Italy
IRMED
RECRUITING

Piotrkow Trybunalski, 97-300, Poland
Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
NOT_YET_RECRUITING

Mexico City, 14080, Mexico
Instituto de Investigaciones Aplicadas a la Neurociencia A.C.
RECRUITING

Durango, 34000, Mexico
Jiangsu Province Hospital
RECRUITING

Nanjing, 210029, China
Jávorszky Ödön Kórház
RECRUITING

Vác, 2600, Hungary
Kocaeli University Medical Faculty Hospital
RECRUITING

İzmit, 41380, Turkey (Türkiye)
Komarom-Esztergom Varmegyei Szent Borbala Korhaz
RECRUITING

Tatabánya, 2800, Hungary
London Digestive Disease Institute
RECRUITING

London, N6K 1M6, Canada
London Health Sciences Centre
NOT_YET_RECRUITING

London, N6A 5W9, Canada
Mahavir Hospital & Research Centre - Hyderabad
NOT_YET_RECRUITING

Hyderabad, 500004, India
Mayo Clinic in Arizona - Scottsdale
RECRUITING

Scottsdale, Arizona, 85259, United States
Medical Network Spółka z o.o. WIP Warsaw IBD Point Profesor Kierkuś
RECRUITING

Warsaw, 04-501, Poland
Medimanage Research
RECRUITING

Tlalpan, 14050, Mexico
Medipoint Hospitals Pvt. Ltd.
RECRUITING

Pune, 411007, India
Medizinische Universität Wien
RECRUITING

Vienna, 1090, Austria
Mersin University
RECRUITING

Mersin, 33110, Turkey (Türkiye)
Midtown Gastroenterology and Liver Disease
RECRUITING

Des Plaines, Illinois, 60016, United States
Mustafa Kemal Universitesi
RECRUITING

Hatay, 31030, Turkey (Türkiye)
National Hospital Organization Osaka National Hospital
RECRUITING

Osaka, 540-0006, Japan
NeoClinical Research
RECRUITING

Hialeah, Florida, 33016, United States
NewData Clinical Research - Maceió
RECRUITING

Maceió, 57020-360, Brazil
Northwestern University
NOT_YET_RECRUITING

Chicago, Illinois, 60611, United States
Odense Universitetshospital
RECRUITING

Odense, 5000, Denmark
Om Research LLC
RECRUITING

Lancaster, California, 93534, United States
Ospedale San Raffaele
RECRUITING

Milan, 20132, Italy
Pannónia Magánorvosi Centrum
RECRUITING

Budapest, 1136, Hungary
Peak Gastroenterology Associates
RECRUITING

Colorado Springs, Colorado, 80907, United States
Pratia Poznań
RECRUITING

Poznan, 60-192, Poland
Radboudumc
RECRUITING

Nijmegen, 6525 GA, Netherlands
Rajiv Gandhi Government General Hospital
RECRUITING

Chennai, 600003, India
S.C Centrul de Gastroenterologie Dr. Goldis S.R.L
RECRUITING

Timișoara, 300002, Romania
Sapporo Tokushukai Hospital
RECRUITING

Sapporo, 004-0041, Japan
Sardar Vallabhbhai Patel Institute of Medical Sciences and Research
RECRUITING

Ahmedabad, 380006, India
Scientia Investigacion Clinica S.C.
RECRUITING

Chihuahua City, 31207, Mexico
Scientia Investigacion Clinica S.C.
RECRUITING

Tijuana, 22105, Mexico
Semmelweis Egyetem
RECRUITING

Budapest, 1088, Hungary
Servicios de Oncología Médica Integral - Monterrey
RECRUITING

San Pedro Garza García, 66220, Mexico
Shengjing Hospital of China Medical University
RECRUITING

Shenyang, 110004, China
Shree Giriraj Multispeciality Hospital
RECRUITING

Rajkot, 360005, India
Sir Run Run Shaw Hospital of Zhejiang University School of Medicine
RECRUITING

Hangzhou, 310018, China
Solare Trials
SUSPENDED

São Paulo, 01307-002, Brazil
Sonomed Sp. z o. o.
RECRUITING

Szczecin, 71-685, Poland
Southern Star Research Institute
RECRUITING

San Antonio, Texas, 78229, United States
Spital Judetean de Urgenta
RECRUITING

Satu Mare, 440055, Romania
Spitalul Clinic Colentina
RECRUITING

Bucharest, 020125, Romania
Studienzentrum MVZ Dachau
RECRUITING

Dachau, 85221, Germany
Sushruta Multispeciality Hospital & Research Centre
RECRUITING

Hubli, 580021, India
Taian City Central Hospital
RECRUITING

Taian, 271000, China
Texas Digestive Disease Consultants - Cedar Park
RECRUITING

Cedar Park, Texas, 78613, United States
The Affiliated Hospital of Qingdao University
RECRUITING

Qingdao, 266003, China
The First Affiliated Hospital Of Fujian Medical University
RECRUITING

Fuzhou, 350005, China
The Second Afilliated Hospital of Hebei Medical University
RECRUITING

Shijiazhuang, 050000, China
Toho University Sakura Medical Center
RECRUITING

Sakura, 285-8741, Japan
Tsujinaka Hospital - Kashiwanoha
RECRUITING

Kashiwa, 277-0871, Japan
Twoja Przychodnia SCM
RECRUITING

Szczecin, 71-434, Poland
Tyler Research Institute
RECRUITING

Tyler, Texas, 75701, United States
Universidade Federal Do Piaui - Campos Universitario
RECRUITING

Teresina, 64049-550, Brazil
Universitaetsklinikum Erlangen
NOT_YET_RECRUITING

Erlangen, 91054, Germany
Universitaetsklinikum Ulm
RECRUITING

Ulm, 89081, Germany
University Gastroenterology - Providence - West River Street
RECRUITING

Providence, Rhode Island, 02904, United States
Universitätsklinikum Regensburg
NOT_YET_RECRUITING

Regensburg, 93053, Germany
Uniwersyteckie Centrum Stomatologii i Medycyny Specjalistycznej
RECRUITING

Poznan, 60-354, Poland
WSD MEDI
RECRUITING

Warsaw, 02-786, Poland
Washington Gastroenterology - Bellevue
RECRUITING

Bellevue, Washington, 98004, United States
West GTA Research Inc.
RECRUITING

Mississauga, L5M 2S4, Canada
Wuhan Union Hospital
RECRUITING

Wuhan, 430022, China
Wuxi People's Hospital
RECRUITING

Wuxi, 214023, China
Óbudai Egészségügyi Centrum
RECRUITING

Budapest, 1036, Hungary
İnönü Üniversitesi Turgut Özal Tıp Merkezi Eğitim ve Araştırma Hastanesi
RECRUITING

Malatya, 44280, Turkey (Türkiye)

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