Oxygen therapy may help hospitalized colitis patients avoid surgery
NCT ID NCT05987852
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) can help people hospitalized with moderate to severe ulcerative colitis flares. The goal is to see if this treatment can stop symptoms like rectal bleeding and frequent stools, and reduce the need for stronger medications or surgery. About 126 adults aged 18 to 85 will take part, receiving either real or sham oxygen sessions. The approach aims to improve oxygen levels in the gut to reduce inflammation.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Allegheny Health
RECRUITINGPittsburgh, Pennsylvania, 15090, United States
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Cornell University Medical Center
ACTIVE_NOT_RECRUITINGNew York, New York, 10065, United States
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Dartmouth Hitchcock Medical Center
RECRUITINGLebanon, New Hampshire, 03756, United States
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Massachusetts General Hospital
RECRUITINGBoston, Massachusetts, 02114, United States
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Mayo Clinic
RECRUITINGRochester, Minnesota, 55905, United States
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Northwestern Medicine Lake Forest Hospital
RECRUITINGLake Forest, Illinois, 60045, United States
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Orlando Health
RECRUITINGOrlando, Florida, 32806, United States
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State University of New York Upstate Medical University
RECRUITINGSyracuse, New York, 13210, United States
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University of Alabama Medicine
RECRUITINGBirmingham, Alabama, 35233, United States
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University of Los Angeles Health
RECRUITINGLos Angeles, California, 90024, United States
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University of Louisville
RECRUITINGLouisville, Kentucky, 40202, United States
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University of Miami Health
RECRUITINGMiami, Florida, 33136, United States
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University of Pittsburgh Medical Center
RECRUITINGPittsburgh, Pennsylvania, 15213, United States
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