Double drug attack on ulcerative colitis shows promise

NCT ID NCT06095128

Recruiting now Disease control Sponsor: Takeda Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Aug 13, 2026 · Updated 5 times

Summary

This study tests whether combining two drugs—vedolizumab and tofacitinib—can quickly bring moderate to severe ulcerative colitis under control. About 65 adults will receive both drugs for 8 weeks, and those who respond will continue on vedolizumab alone for nearly a year. The goal is to see if this approach leads to remission and long-term symptom control.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: vedolizumab and tofacitinib
What this could lead to: If successful, this could offer a new dual-drug strategy to quickly control ulcerative colitis and then maintain remission with a single drug.
What could go wrong: This is a small, early-phase study with only 65 participants and no placebo group, so results may not apply broadly. Combining two immune-suppressing drugs also raises infection risks.

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Conditions

The condition(s) this trial relates to.

ulcerative colitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ULCERATIVE COLITIS

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

ABP Research Services Corp.
RECRUITING

Oakville, Ontario, L6L 5L7, Canada
Allegheny Health Network
RECRUITING

Wexford, Pennsylvania, 15090, United States
Alliance Clinical Research of Tampa, LLC
RECRUITING

Tampa, Florida, 33615, United States
BVL Clinical Research
RECRUITING

Liberty, Missouri, 64068, United States
Barrie GI Associates Inc.
RECRUITING

Barrie, Ontario, L4M 7G1, Canada
Capital Digestive Care - MGG Group - Chevy Chase Clinical Research
RECRUITING

Chevy Chase, Maryland, 20815, United States
Cedars-Sinai Medical Center
RECRUITING

Los Angeles, California, 90048, United States
Digestive Health Partners
RECRUITING

Asheville, North Carolina, 28801, United States
Digestive Health Specialsits
RECRUITING

Dothan, Alabama, 36301, United States
Endoscopic Research Inc
RECRUITING

Orlando, Florida, 32803, United States
GI Alliance
RECRUITING

Metairie, Louisiana, 70006, United States
GI Alliance - Digestive Health Associates of Texas
RECRUITING

Dallas, Texas, 75044, United States
GI Alliance - Mansfield
RECRUITING

Mansfield, Texas, 76063, United States
GI Alliance - Webster
RECRUITING

Webster, Texas, 77598, United States
GI Alliance Sun City
RECRUITING

Sun City, Arizona, 85351, United States
Gastro Intestinal Research Institute of Northern Ohio, LLC.
RECRUITING

Westlake, Ohio, 44145, United States
Gastroenterology Consultants, P.C.
RECRUITING

Roswell, Georgia, 30076, United States
Gastroenterology Research of San Antonio, LLC
RECRUITING

San Antonio, Texas, 78229, United States
Hoag Hospital Newport Beach
RECRUITING

Newport Beach, California, 92663, United States
Huron Gastroenterology Associates, P.C.
RECRUITING

Ypsilanti, Michigan, 48197, United States
London Health Sciences Centre
RECRUITING

London, Ontario, N6A 5A5, Canada
MNGI Digestive Health, PA
RECRUITING

Plymouth, Minnesota, 55446, United States
Mid-America Gastro-Intestinal Consultants
RECRUITING

Kansas City, Missouri, 64111, United States
NYU Langone Health
RECRUITING

New York, New York, 10016, United States
Ohio Gastroenterology group, Inc.
RECRUITING

Columbus, Ohio, 43202, United States

Contact Email: •••••@•••••
Sanford Health Research
RECRUITING

Rapid City, South Dakota, 57701, United States
Taunton Surgical Centre
RECRUITING

Oshawa, Ontario, L1J 0C7, Canada
Texas Digestive Disease Consultants (TDDC), Southlake
RECRUITING

Southlake, Texas, 76092, United States
The Research Institute of the McGill University Health Centre
RECRUITING

Montreal, Quebec, H3G 1A4, Canada
The University of Texas Health Science Center at Houston
RECRUITING

Houston, Texas, 77030, United States
Toronto Digestive Disease Associates (TDDA) Inc.
RECRUITING

Vaughan, Ontario, L4L 4Y7, Canada
Toronto Immune and Digestive Health Institute Inc. (TIDHI)
RECRUITING

North York, Ontario, M6A3B4, Canada
Tulane University
RECRUITING

New Orleans, Louisiana, 70112, United States
Tyler Research Institute, LLC
RECRUITING

Tyler, Texas, 75701, United States
University Gastroenterology
RECRUITING

Providence, Rhode Island, 02094, United States
University of Chicago Medicine
RECRUITING

Chicago, Illinois, 60637, United States
University of Cincinnati
RECRUITING

Cincinnati, Ohio, 45627, United States
University of Kansas Medical Center
RECRUITING

Kansas City, Kansas, 66160, United States
University of Louisville
RECRUITING

Louisville, Kentucky, 40202, United States
University of North Carolina
RECRUITING

Chapel Hill, North Carolina, 27599, United States
University of Utah Health
RECRUITING

Salt Lake City, Utah, 84108, United States
Viable Clinical Research - North Bay
RECRUITING

North Bay, Ontario, P1B 2H3, Canada
Washington Gastroenterology- GIA
RECRUITING

Tacoma, Washington, 98405, United States
Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States
Weill Cornell Medical College- New York Presbyterian Hospital
RECRUITING

New York, New York, 10065, United States
West GTA Endoscopy Inc.
RECRUITING

Mississauga, Ontario, L5M 7N4, Canada

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