New drug combo aims to tame ulcerative colitis

NCT ID NCT06598943

Recruiting now Disease control Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 31, 2026 · Updated 5 times

Summary

This study tests two drugs, eltrekibart and mirikizumab, alone or together, in 140 adults with moderate-to-severe ulcerative colitis. The goal is to see if they can safely reduce inflammation and help patients achieve remission. Participants must have tried other treatments without success.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: eltrekibart and mirikizumab
What this could lead to: If successful, this could provide a new treatment option for people with ulcerative colitis who haven't responded to other therapies.
What could go wrong: This is an early Phase 2 trial with only 140 participants, so results may not apply to everyone. The drugs may cause side effects or fail to improve symptoms.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

colitis colonic disorder Digestive System Diseases digestive system disorder inflammatory bowel disease intestinal disorder ulcerative colitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ULCERATIVE COLITIS ULCERATIVE COLITIS CHRONIC

Contacts and locations

Locations

A.O.U. Citta' della Salute e della Scienza di Torino
RECRUITING

Torino, 10126, Italy
A.O.U. Policlinico G. Martino
RECRUITING

Gazzi - Messina, 98125, Italy
AST Pesaro Urbino - Presidio Ospedaliero Santa Croce
RECRUITING

Fano, 61032, Italy
AZ Gastro Care - Chandler
NOT_YET_RECRUITING

Chandler, Arizona, 85225, United States
Advanced Research Institute - South Ogden
RECRUITING

Ogden, Utah, 84405, United States
AdventHealth Orlando
NOT_YET_RECRUITING

Orlando, Florida, 32803, United States
Alexandra Hospital
RECRUITING

Athens, 11528, Greece
Applied Research Center of Arkansas
RECRUITING

Little Rock, Arkansas, 72205, United States
Avicenna Clinical Research - SW Gastroenterology
RECRUITING

Oak Lawn, Illinois, 60453-3754, United States
Azienda Ospedale Università di Padova
RECRUITING

Padova, 35128, Italy
Azienda Ospedaliera Universitaria Careggi
RECRUITING

Florence, 50134, Italy
Azienda Ospedaliero Universitaria
NOT_YET_RECRUITING

Modena, 41124, Italy
Baylor College of Medicine
RECRUITING

Houston, Texas, 77030, United States
Beaumont Hospital, Dublin
RECRUITING

Dublin, D9, Ireland
Bispebjerg Hospital
NOT_YET_RECRUITING

København NV, 2400, Denmark
Bugát Pál Kórház
NOT_YET_RECRUITING

Gyöngyös, 3200, Hungary
CEIM Hospital Universitario y Politecnico la Fe
RECRUITING

Valencia, 46026, Spain
CER Instituto Medico
NOT_YET_RECRUITING

Quilmes, B1878DVB, Argentina
CHU De Grenoble Hopital Albert Michallon
RECRUITING

Grenoble, 38043, France
CHU UCL Namur site Godinne
RECRUITING

Yvoir, 5530, Belgium
CHU de Nice Hopital de L'Archet
RECRUITING

Nice, 06202, France
CIPREC
RECRUITING

CABA, C1061AAS, Argentina
CIUSSS de l'Est-de-l'Île-de-Montréal
NOT_YET_RECRUITING

Montreal, H1T 2M4, Canada
Care Access-Ogden
RECRUITING

Ogden, Utah, 84403, United States
Centre Hospitalier Departemental (CHD) Vendee
RECRUITING

La Roche-sur-Yon, 85925, France
Centro Medico Privado de Reumatologia
RECRUITING

SAN M. de Tucuman, T4000AXL, Argentina
Centro Medico Teknon - DIGESTIVO
RECRUITING

Barcelona, 8022, Spain
Centro de Inmunología y Genética (CIGE)
NOT_YET_RECRUITING

Medellín, 5001000, Colombia
Centrum Medyczne Kermed Renata Bojata-Bronisz i Ewa Kowalińska Sp.j.
RECRUITING

Bydgoszcz, 85-231, Poland
Centrum Medyczne Oporów
RECRUITING

Wroclaw, 52-416, Poland
Centrum Medyczne Plejady Magdalena Celińska-Löwenhoff, Michał Żołnowski sp.k
RECRUITING

Krakow, 30-363, Poland
Centrum Nowoczesnych Terapii "Dobry Lekarz" sp. z o. o.
RECRUITING

Krakow, 31-011, Poland
Charité Campus Virchow-Klinikum
RECRUITING

Berlin, 13353, Germany
Chiba University Hospital
NOT_YET_RECRUITING

Chiba, 260-8677, Japan
Chu Tivoli
RECRUITING

La Louvière, 7100, Belgium
Chu de Rouen Hopital Charles Nicolle
RECRUITING

Rouen, 76031, France
Clinexpert Egészségügyi Szolgáltató és Kereskedelmi Kft
RECRUITING

Budapest, 1033, Hungary
Clinexpert Gyöngyös Kft.
NOT_YET_RECRUITING

Gyöngyös, 3200, Hungary
Clinical Center " Dr Dragisa Misovic Dedinje"
RECRUITING

Belgrade, 11000, Serbia
Clinical Center of Vojvodina
RECRUITING

Novi Sad, 21000, Serbia
Clinical Hospital Center Bezanijska Kosa
RECRUITING

Belgrade, 11000, Serbia
Clinical Hospital Center Zvezdara
RECRUITING

Belgrade, 11000, Serbia
Clinical Hospital Centre Zemun
NOT_YET_RECRUITING

Belgrade, 11000, Serbia
Clinical Trials Management Services, LLC
RECRUITING

Thousand Oaks, California, 91360, United States
Clinical Trials Management, LLC
NOT_YET_RECRUITING

Metairie, Louisiana, 70006, United States
Clinnova Research
RECRUITING

Orange, California, 92868-4402, United States
Clínica Privada Independencia
NOT_YET_RECRUITING

Munro, 1605, Argentina
Colentina Clinical Hospital
RECRUITING

Bucharest, 020125, Romania
Comité de Ética en Investigación Biomédica IPS Centro Médico Julián Coronel
NOT_YET_RECRUITING

Cali, 750035, Colombia
DHR Health Gastroenterology - Edinburg
RECRUITING

Edinburg, Texas, 78539, United States
Digestive Disease Consultants DDCJAX
NOT_YET_RECRUITING

Orange Park, Florida, 32073-4752, United States
Digestive Disease Medicine of Central New York
RECRUITING

Utica, New York, 13502, United States
Dr.Carol Davila Emergency University Central Military Hospital
NOT_YET_RECRUITING

Bucharest, 010825, Romania
Ege Universitesi Hastanesi
NOT_YET_RECRUITING

Izmir, 35100, Turkey (Türkiye)
Ellipsis Research Group
RECRUITING

Brooklyn, New York, 11215, United States
Emergency University Hospital
RECRUITING

Bucharest, 50098, Romania
Endoskopia Sp. z.o.o.
RECRUITING

Sopot, 81-756, Poland
Erick Alayo Medical Corp/Gastro SB Clinic
RECRUITING

Chula Vista, California, 91910, United States
Etická komise Krajské nemocnice T. Bati, a. s.
RECRUITING

Zlín, 762 75, Czechia
Etická komise Nemocnice Slaný
RECRUITING

Slaný, 27401, Czechia
Fejér Megyei Szent György Egyetemi Oktató Kórház
RECRUITING

Székesfehérvár, 8000, Hungary
Florida Research Institute
NOT_YET_RECRUITING

Lakewood Rch, Florida, 34211, United States
Fondazione IRCCS Policlinico San Matteo
RECRUITING

Pavia, 27100, Italy
Fondazione Poliambulanza
NOT_YET_RECRUITING

Brescia, 25124, Italy
Fukuoka University Chikushi Hospital
RECRUITING

Chikushino-shi, 818-8502, Japan
GCGA Physicians, LLC dba / Gastro Health Research
RECRUITING

Cincinnati, Ohio, 45219, United States
GCP Clinical Research, LLC
RECRUITING

Tampa, Florida, 33609, United States
Gastroenterology Associates of Western Michigan, P.L.C.
RECRUITING

Wyoming, Michigan, 49519, United States
Gastroenterology Research of San Antonio
RECRUITING

San Antonio, Texas, 78229, United States
Gastromed Sp. z o.o.
RECRUITING

Torun, 87-100, Poland
Gazi University Medical Faculty Gazi Hospital
NOT_YET_RECRUITING

Ankara, 6560, Turkey (Türkiye)
General Hospital "Djordje Joanovic"
RECRUITING

Zrenjanin, 23000, Serbia
General Hospital Dr Andjelko Visic Bjelovar
RECRUITING

Bjelovar, 43000, Croatia
General Hospital Dr. J. Bencevic
NOT_YET_RECRUITING

Slavonski Brod, 35 000, Croatia
General Hospital Pancevo
RECRUITING

Pančevo, 26101, Serbia
General Hospital of Athens 'Evangelismos'
RECRUITING

Athens, 10676, Greece
General Hospital of Athens Hippokratio
RECRUITING

Athens, 115 27, Greece
General Oncology Hospital of Kifissia "Agioi Anargiroi"
NOT_YET_RECRUITING

Nea Kifissia, 14564, Greece
H-T. Centrum Medyczne-Endoterapia
NOT_YET_RECRUITING

Tychy, 43-100, Poland
HaFCED e.K. - Hamburgisches Forschungsinstitut für chronisch entzündliche Darmerkrankungen
NOT_YET_RECRUITING

Hamburg, 20251, Germany
Hachinohe City Hospital
NOT_YET_RECRUITING

Hachinohe-shi, 031-8555, Japan
Henri Mondor Hospital
RECRUITING

Créteil, 94010, France
Hiroshima City North Medical Center Asa Citizens Hospital
RECRUITING

Hiroshima, 731-0293, Japan
Hiroshima University Hospital
NOT_YET_RECRUITING

Hiroshima, 734-8551, Japan
Hoshi General Hospital Foundation
NOT_YET_RECRUITING

Koriyama-shi, 963-8801, Japan
Hospices Civils de Lyon - Centre Hospitalier Lyon Sud -
RECRUITING

Pierre-Bénite, 69495, France
Hospital Clínico Universitario de Santiago de Compostela
RECRUITING

Santiago de Compostela, 15706, Spain
Hospital General Tomelloso
RECRUITING

Ciudad Real, 13700, Spain
Hospital Provincial del Centenario
RECRUITING

Rosario, S2002KDS, Argentina
Hospital Universitario Juan Ramon Jimenez
RECRUITING

Huelva, 21005, Spain
Hospital Universitario La Paz
RECRUITING

Madrid, 28046, Spain
Hospital Universitario Mayor Méderi
NOT_YET_RECRUITING

Bogotá, 111411, Colombia
Hospital Universitario Reina Sofia Comite Etico
RECRUITING

Córdoba, 14004, Spain
Hospital Universitario Virgen Macarena
RECRUITING

Seville, 41009, Spain
Hospital Universitario de Gran Canaria Doctor Negrín
RECRUITING

Las Palmas de GC, 35019, Spain
Hyogo College of Medicine
RECRUITING

Nishinomiya, 663-8501, Japan
I.V.A.M. Clinical & Investigational Center, LLC
NOT_YET_RECRUITING

Doral, Florida, 33126, United States
IRCCS - AOU di Bologna
RECRUITING

Bologna, 40138, Italy
IRCCS Ospedale Casa Sollievo della Sofferenza
RECRUITING

San Giovanni Rotondo, 71013, Italy
IRCCS Ospedale San Raffaele
RECRUITING

Segrate, 20132, Italy
IRCCS Policlinico San Donato
RECRUITING

San Donato Milanese, 20097, Italy
Infusion Clinic
RECRUITING

Osaka, 530-0011, Japan
Inquest Clinical Research
RECRUITING

Baytown, Texas, 77521, United States
Institutul Regional de Gastroenterologie și Hepatologie Prof. Dr. Octavian Fodor
RECRUITING

Cluj-Napoca, 400162, Romania
Interdisziplinäres Crohn Colitis Centrum Rhein-Main
NOT_YET_RECRUITING

Frankfurt am Main, 60594, Germany
Intergrity Research
RECRUITING

Houston, Texas, 77043, United States
International Center for Research LLC
RECRUITING

Tampa, Florida, 33614, United States
Ip Clinic Sp. Z O. O.
RECRUITING

Lodz, 90-752, Poland
Isesaki Municipal Hospital
RECRUITING

Isesaki-shi, 372-0817, Japan
Istituto Clinico Humanitas
RECRUITING

Rozzano, 20089, Italy
Iwate Medical University Hospital
RECRUITING

Morioka, 020-8505, Japan
JCHO Kyushu Hospital
NOT_YET_RECRUITING

Kitakyushu-Shi, 806 8501, Japan
JHCO Tokyo Yamate Medical Center
NOT_YET_RECRUITING

Shinjuku-ku, 169-0073, Japan
Kagoshima IBD Gastroenterology Clinic
RECRUITING

Kagoshima, 892-0843, Japan
Kitasato University Kitasato Institute Hospital
RECRUITING

Minatoku, 108 8642, Japan
Klinikum Rechts der Isar der TU München
RECRUITING

München, 81675, Germany
Kyorin University Hospital
RECRUITING

Mitaka, 181-8611, Japan
Liepaja Regional Hospital
RECRUITING

Liepāja, LV-3414, Latvia
London Digestive Disease Institute
NOT_YET_RECRUITING

London, N6K 1M6, Canada
London Health Sciences Centre
RECRUITING

London, N6A 5W9, Canada
MVZ für spezialärztliche Versorgung Dr. Friedrichs GmbH
RECRUITING

Duisburg, 47055, Germany
Magen-Darm-Zentrum Remscheid
RECRUITING

Remscheid, 42859, Germany
ManerMed Sp z o.o. Centrum Medyczne ,Medis
RECRUITING

Bydgoszcz, 85-229, Poland
Matsushima Hospital
NOT_YET_RECRUITING

Yokohama, 220 0041, Japan
Mautalen Salud e Investigacion-Centro de Osteopatías Médicas
RECRUITING

Ciudad Autonoma de Buenos Air, C1128AAF, Argentina
Med-GASTR SP. Z O.O., SP.K.
RECRUITING

Lodz, 91 034, Poland
Medical Research Center of Connecticut, LLC
RECRUITING

Hamden, Connecticut, 06518-3602, United States
Medizinische Hochschule Hannover
RECRUITING

Hanover, 30625, Germany
Medrise Sp. z o.o
RECRUITING

Lublin, 20-582, Poland
Melita Medical
RECRUITING

Wroclaw, 53-611, Poland
Mersin University Medical Faculty Hospital
NOT_YET_RECRUITING

Mersin, 33169, Turkey (Türkiye)
Mie University Hospital
RECRUITING

Tsu, 514-8507, Japan
Military Medical Academy
RECRUITING

Belgrade, 11000, Serbia
Montreal General Hospital
NOT_YET_RECRUITING

Montreal, H3G 1A4, Canada
NTT Medical Center Tokyo
NOT_YET_RECRUITING

Shinagawa-KU, 141-8625, Japan
NZOZ FOR MED sp. z o.o.
RECRUITING

Wadowice, 34-100, Poland
Nara Prefecture General Medical Center
RECRUITING

Nara, 630-8054, Japan
National Hospital Organization Hirosaki General Medical Center
NOT_YET_RECRUITING

Hirosaki, 036-8545, Japan
National Hospital Organization Kanazawa Medical Center
NOT_YET_RECRUITING

Kanazawa, 920-8650, Japan
National Hospital Organization Shizuoka Medical Center
RECRUITING

Sunto-gun, 411-8611, Japan
NexGen Research
RECRUITING

Lima, Ohio, 45801, United States
Nodal Medical Center
RECRUITING

Tampa, Florida, 33607, United States
Northwestern University
NOT_YET_RECRUITING

Chicago, Illinois, 60611, United States
Novum Research, LLC
NOT_YET_RECRUITING

Clermont, Florida, 34711, United States
Oita Red Cross Hospital
NOT_YET_RECRUITING

Ōita, 870-0033, Japan
Om Research LLC
RECRUITING

Victorville, California, 92395, United States
Om Research, LLC
RECRUITING

Lancaster, California, 93534, United States
Orlando Health Digestive Health Institute
RECRUITING

Orlando, Florida, 32803-1248, United States
Ospedale S. Paolo
RECRUITING

Milan, 20142, Italy
Ospedale Sandro Pertini
NOT_YET_RECRUITING

Roma, 157, Italy
Our Lady of the Snow St. Mary's Hospital
NOT_YET_RECRUITING

Kurume-shi, 830 8543, Japan
PAGNI-University General Hospital of Heraklion
RECRUITING

Heraklion, 71500, Greece
Pauls Stradins Clinical Univeristy Hospital
RECRUITING

Riga, LV-1002, Latvia
Peak Gastroenterology Associates
RECRUITING

Colorado Springs, Colorado, 80907-6262, United States
Pioneer Clinical Research NY
RECRUITING

New York, New York, 10012-3645, United States
Policlinico Tor Vergata
RECRUITING

Roma, 00133, Italy
Policlinico Universitario Campus Bio-Medico
RECRUITING

Rome, 00128, Italy
Poliklinika Borzan
RECRUITING

Osijek, 31000, Croatia
Poliklinika Solmed
RECRUITING

Zagreb, 10000, Croatia
Preferred Research Partners
NOT_YET_RECRUITING

Little Rock, Arkansas, 72211, United States
Prospective Research Innovations
RECRUITING

Rancho Cucamonga, California, 91730-4850, United States
Research Bay,Inc.
RECRUITING

Tampa, Florida, 33607, United States
Reserka
NOT_YET_RECRUITING

Miami, Florida, 33176, United States
S.C Centrul de Gastroenterologie Dr. Goldis S.R.L
RECRUITING

Timișoara, 300002, Romania
S.C. Centrul Medical Medicum SRL
RECRUITING

Bucharest, 012015, Romania
SC Farmacia AO Ordine Mauriziano
RECRUITING

Torino, 10128, Italy
Saiseikai Fukuoka General Hospital
NOT_YET_RECRUITING

Fukuoak, 810-0001, Japan
Sapporo Higashi Tokushukai Hospital
RECRUITING

Sapporo, 065-0033, Japan
Sapporo IBD Clinic
RECRUITING

Sapporo Shi Chuo Ku, 064-0919, Japan
Semmelweis University
RECRUITING

Budapest, 1088, Hungary
Showa University Koto Toyosu Hospital
NOT_YET_RECRUITING

Kōtoku, 135 8577, Japan
Smart Medical Research - Jackson Heights
RECRUITING

Jackson Heights, New York, 11372, United States
Sotiria Thoracic Diseases Hospital of Athens
RECRUITING

Athens, 11527, Greece
Southern California GI and Liver Centers (SCLC)
RECRUITING

Coronado, California, 92118, United States
Special Hospital Medico
RECRUITING

Rijeka, 51000, Croatia
Studiengesellschaft BSF Unternehmergesellschaft
RECRUITING

Halle, 06108, Germany
SurGal clinic s.r.o.
NOT_YET_RECRUITING

Brno, 60200, Czechia
Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ
NOT_YET_RECRUITING

Szeged, 6725, Hungary
Tokai University Hospital
RECRUITING

Isehara, 259-1193, Japan
Tokushukai Sapporo Tokushukai Hospital
RECRUITING

Sapporo, 40041, Japan
Tokyo Metro Bokutoh Hospital
NOT_YET_RECRUITING

Sumida-ku, 130-8575, Japan
Topolowa Medicenter Ryszawa & Wspólnicy Sp.j.
RECRUITING

Krakow, 31-506, Poland
Toyama University Hospital
RECRUITING

Toyama, 930-0194, Japan
Tsujinaka Hospital Kashiwanoha
RECRUITING

Kashiwa, 277-0871, Japan
Twoja Przychodnia Opolskie Centrum Medyczne
RECRUITING

Opole, 45 819, Poland
Twoja Przychodnia Pcm
RECRUITING

Poznan, 60-324, Poland
Tyler Research Institute
RECRUITING

Tyler, Texas, 75701, United States
United Medical Doctors
RECRUITING

Los Alamitos, California, 90720-3433, United States
University Hospital Center Zagreb
NOT_YET_RECRUITING

Zagreb, 10000, Croatia
University Hospital of Ioannina
RECRUITING

Ioannina, 45500, Greece
University of North Carolina
RECRUITING

Chapel Hill, North Carolina, 27599, United States
University of Washington School Medicine
NOT_YET_RECRUITING

Seattle, Washington, 98195, United States
Università di Cagliari - Presidio Policlinico Monserrato
RECRUITING

Monserrato, 09042, Italy
Universitätsklinikum Augsburg, III. Medizinische Klinik Studienzentrum
RECRUITING

Augsburg, 86156, Germany
Universitätsklinikum Brandenburg GmbH
RECRUITING

Brandenburg an der Havel, 14770, Germany
Universitätsklinikum Frankfurt Goethe-Universität, Medizinische Klinik 1
RECRUITING

Frankfurt am Main, 60590, Germany
Universitätsklinikum Schleswig-Holstein
RECRUITING

Kiel, 24105, Germany
Universitätsklinikum Ulm
NOT_YET_RECRUITING

Ulm, 89081, Germany
VISTAMED
RECRUITING

Wroclaw, 53-149, Poland
Valahia Medical Center SRL
RECRUITING

Ploieşti, 100032, Romania
Valley View Research
RECRUITING

Garden Grove, California, 92845, United States
Vojenska nemocnice Brno p.o.
RECRUITING

Brno, 615 00, Czechia
WIP Warsaw IBD Point Profesor Kierkus
RECRUITING

Warsaw, 04-501, Poland
Well Pharma Medical Research Corp.
RECRUITING

Miami, Florida, 33173, United States
Yamanashi Prefectural Central Hospital
NOT_YET_RECRUITING

Kofu, 400-8506, Japan
Óbudai Egészségügyi Centrum
RECRUITING

Budapest, 1036, Hungary
İnönü Üniversitesi Tıp Fakültesi
NOT_YET_RECRUITING

Malatya, 44280, Turkey (Türkiye)

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