ULCERATIVE COLITIS

This study tests a new drug called ATH-063 in people with moderate to severe ulcerative colitis who have not improved with other advanced treatments. The goal is to see if the drug can reduce symptoms like diarrhea and bleeding and help the gut heal. About 120 adults will receive…

This study tests whether adding acupuncture to the standard drug mesalazine can help people with mild-to-moderate ulcerative colitis achieve and stay in remission. About 80 adults will receive either the combined treatment or mesalazine alone. The goal is to see if the combinatio…

This study tests a blood-filtering device (Efferon LPS) in 40 adults with Crohn's disease or ulcerative colitis during a flare-up. The device is designed to remove harmful substances from the blood to reduce inflammation. Participants will either receive standard care alone or st…

This study will test hyperbaric oxygen therapy (HBOT) in 100 people with various conditions, including long COVID, Crohn's disease, frostbite, and more. HBOT involves breathing pure oxygen in a pressurized chamber to help the body heal. The goal is to see if HBOT improves quality…

This study tests a steroid foam (budesonide) given rectally to children aged 5 to 17 with mild to moderate ulcerative colitis. The goal is to see if it can reduce inflammation and help symptoms like bleeding and frequent bowel movements. About 100 children will receive either the…

This study tests a special diet designed to meet the protein needs of people with ulcerative colitis while reducing harmful gas produced by gut bacteria. Researchers will measure changes in stool samples from 40 adults with mild to moderate disease. The goal is to see if this die…

This study tests whether a natural mineral supplement called Aquamin can prevent pouchitis, a painful inflammation of the J-pouch, in people who had surgery for ulcerative colitis. About 52 participants who recently had J-pouch surgery will take Aquamin or a placebo. The goal is …

This study tests whether a 5-week breathing training program (heart rate variability biofeedback) can reduce symptoms like belly pain and bloating in people with mild ulcerative colitis. Twenty-three adults with active symptoms but no active gut inflammation will practice slow, p…

This study tests a one-day acceptance and commitment therapy (ACT) program designed for veterans who have both inflammatory bowel disease (like Crohn's or colitis) and mental health conditions such as depression, anxiety, or PTSD. The goal is to see if this brief program is pract…

This study tests whether a special sleep therapy (CBT-I) delivered over video calls can help adults with ulcerative colitis who also have insomnia. About 20 people will take part in 5 therapy sessions and complete online sleep diaries and questionnaires. The goal is to see if the…

This study is developing a new questionnaire to measure how well people with inflammatory bowel disease (IBD) take care of themselves. Researchers will interview patients and test the questionnaire with 275 adults to make sure it is accurate and reliable. The goal is to give doct…

This study aims to understand why children with ulcerative colitis (UC) are more likely to get C. difficile infections. Researchers will compare bile acid profiles and gut bacteria in 80 children: those with active UC and C. diff, those with active UC alone, those in remission, a…

This study tests whether a self-management program can improve health and quality of life for people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. The program focuses on changing behaviors to help manage the condition. The study will enr…

This study will follow about 1,200 pregnant women with ulcerative colitis who take the medication ozanimod (Zeposia). Researchers will track the health of the mothers and their babies, looking for any birth defects or pregnancy complications. The goal is to better understand the …

This study follows 50 adults with ulcerative colitis who are already seeing a naturopathic doctor. Over 12 weeks, researchers track symptom changes using questionnaires. The goal is to gather early information on how naturopathic care may help, without changing any treatments.