ULCERATIVE COLITIS

This study looks at the long-term safety and effectiveness of a daily pill called ABX464 for people with moderate to severe ulcerative colitis. Participants had already seen improvement in a previous study and will take the drug for up to 54 months. The goal is to see if the drug…

This study tests an oral medication called tofacitinib in 118 children (ages 2 to 17) with moderate-to-severe ulcerative colitis, a chronic bowel disease. The goal is to see if the drug can bring the disease into remission (fewer symptoms and healed gut lining) and keep it under …

This study tests a new drug called emvistegrast (GS-1427) for people with moderate to severe ulcerative colitis, a condition that causes inflammation and sores in the colon. About 228 adults will receive either the drug or a placebo to see if it helps reduce symptoms like bleedin…

This early study tests CP101, a capsule containing beneficial gut bacteria, in 30 adults with mild-to-moderate ulcerative colitis. The goal is to see if the bacteria can safely take hold in the gut and help control the disease. Participants receive either a short or extended cour…

This study explores whether avoiding gluten can slow disease progression and ease symptoms in people with primary sclerosing cholangitis (PSC) and inflammatory bowel disease (IBD). Researchers will track changes in lab results, gut bacteria, and quality of life in 60 adults over …

This study tests whether transplanting healthy donor stool into the gut can help people with ulcerative colitis achieve remission without steroids. About 150 adults with active or steroid-dependent colitis will receive either real fecal transplants or a sham procedure. The goal i…

This study looks at whether adding hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) to standard treatment can help people with severe ulcerative colitis or hard-to-treat inflammatory bowel disease. The goal is to see if it improves symptoms and helps the…

This study follows about 500 adults with moderate to severe ulcerative colitis who are starting filgotinib, a medication that helps control the disease. Researchers want to see how long people stay on the drug, how well it works, and how it affects quality of life in everyday med…

This study tests a digital health system that reminds people with inflammatory bowel disease (IBD) to take their medication and lets them report symptoms. 123 adults starting a new oral or injectable treatment will use the system or standard care for 12 months. The goal is to see…

This study tests a new medicine called BI 3032950 in 45 adults with moderate to severe ulcerative colitis who haven't improved with other treatments. The treatment starts with an IV infusion every 4 weeks for 12 weeks, then switches to a shot under the skin every 4 weeks for up t…

This study tests whether a plant-based resistant starch, tailored to each child's gut, can help restore a healthier gut microbiome in 80 children with Crohn's disease or ulcerative colitis. Participants will take the starch or a placebo for several months while researchers measur…

This study tests a new drug called MK-7240 (tulisokibart) in about 1020 people with moderate-to-severe ulcerative colitis. The goal is to see if it can help patients achieve and maintain remission (fewer symptoms and healed gut lining) compared to a placebo. Participants will be …

This study tests an experimental drug called lutikizumab for people with moderate to severe ulcerative colitis, a condition causing colon inflammation and bleeding. About 200 adults will receive either lutikizumab or the standard drug adalimumab for up to 52 weeks to see which wo…

This study tests whether using a computer dashboard (iDose) to guide infliximab dosing is more effective and safer than standard dosing for people with Crohn's disease or ulcerative colitis. About 124 adults and teens will be followed for a year to see if the dashboard approach h…

This study tests an oral medication called TAK-279 in 207 adults with moderate to severe ulcerative colitis. Participants take either TAK-279 or a placebo for 12 weeks, then all receive TAK-279 for up to a year. The goal is to see if the drug reduces bowel inflammation and sympto…

This study tests the drug upadacitinib (RINVOQ) in children aged 2–17 with moderate-to-severe ulcerative colitis who haven't improved with standard treatments. The trial has three parts: an 8-week open-label phase where all kids get the drug, a 44-week blinded phase comparing two…

This study tests whether Aquamin, a natural supplement made from red marine algae, can help people with mild ulcerative colitis feel better and stay in remission. About 40 adults with confirmed ulcerative colitis who are either in stable remission or have mild symptoms will take …

This study tests whether a fecal transplant (FMT) can safely treat children with recurrent C. difficile infection, especially those with inflammatory bowel disease (IBD). Researchers will give FMT to 250 kids aged 3-21 and watch for side effects and whether the infection comes ba…

This study looks at how well and how safely the drug mirikizumab works over the long term (up to 3 years) for people with moderate to severe ulcerative colitis. About 1,058 adults who were already in earlier studies will continue receiving the drug. The goal is to see if it can k…

This study looks at whether taking a common ulcerative colitis medication (5-ASA) in the morning versus the evening can reduce gut inflammation and improve gut bacteria. About 32 adults with inactive UC but signs of low-level inflammation will take their daily pill at two differe…

This study tests a new drug called rosnilimab in 132 adults with moderate to severe ulcerative colitis, a condition causing inflammation in the colon. Participants receive either the drug or a placebo to see if it reduces disease activity and improves symptoms like diarrhea and b…

This early-phase study tests whether delivering a person's own fat-derived stem cells directly into an artery is safe for treating moderate to severe ulcerative colitis. About 20 adults aged 18-65 who have not responded to at least two standard medications will receive the treatm…

This study tests whether a daily dose of ABX464 (25 mg or 50 mg) can help people with moderate-to-severe ulcerative colitis stay in remission longer. About 1,100 participants who completed an earlier induction study will receive either ABX464 or a placebo for 44 weeks. The goal i…

This study tests a drug called guselkumab in people with moderate to severe ulcerative colitis, a condition causing inflammation in the colon. The goal is to see if the drug can reduce symptoms like diarrhea and bleeding, and help heal the gut lining. Over 1,000 adults who haven'…

This study aimed to see if adding MitoQ (an antioxidant supplement) to standard treatment helps control inflammation in children aged 6–17 with mild-to-moderate ulcerative colitis. Participants would have taken MitoQ or a placebo daily for 24 weeks alongside their usual medicatio…

This study tests an experimental drug called ALTB-268 in 50 adults with moderate-to-severe ulcerative colitis that did not improve with biologic therapies. The goal is to see if the drug can reduce disease activity, measured by a standard score. Participants receive the drug open…

This study looks at the long-term safety and effectiveness of the drug etrasimod for people with moderate to severe ulcerative colitis. Participants had already taken etrasimod or a placebo in earlier studies. The goal is to see if the drug can help control the disease over time,…

This study tests whether a plant-based resistant starch, tailored to each child, can help restore a healthier gut microbiome in 100 children with Crohn's disease or ulcerative colitis. Participants must have mild disease or be in remission. The goal is to increase butyrate produc…

This study tests whether transplanting healthy donor stool into the gut can safely control ulcerative colitis symptoms over the long term and reduce the need for steroids. About 30 people aged 10–80 with mild to moderate disease will receive the treatment and be followed for 48 w…

This study tests whether atorvastatin, a widely used cholesterol-lowering drug, can reduce the risk of colon cancer in people with long-standing ulcerative colitis who carry a specific genetic mutation (P53). About 42 participants will take either atorvastatin or a placebo for a …

This study looks at whether mirikizumab can reduce the sudden, urgent need to use the bathroom in adults with moderate-to-severe ulcerative colitis. About 172 participants will receive the drug and report their urgency levels over 36 weeks. The goal is to see if the treatment imp…

This study is not testing a new treatment. Instead, it looks back at the medical records of over 1,000 adults in Brazil with ulcerative colitis or Crohn's disease who are taking or have taken vedolizumab. The goal is to see how long people stay on the drug and what other treatmen…

This study looks at how doctors prescribe treatments for ulcerative colitis (UC) and aims to create an updated treatment guide. Researchers will track 4,000 patients from a registry to see which treatments work best and when to switch therapies. The goal is to improve long-term o…

This study compares two ways of taking biopsies during colonoscopy in people with inflammatory bowel disease (IBD). About 1642 participants will be randomly assigned to either a limited biopsy approach or a more extensive random biopsy approach. The goal is to see which method fi…

This study tests a program to help teenagers with Crohn's disease or ulcerative colitis move from pediatric to adult healthcare. About 90 teens aged 16 to 17.5 will either get the program (which includes a navigator, skills training, and education) or standard care. The goal is t…

This study follows 15,000 adults and children (age 2+) with Crohn's disease, ulcerative colitis, or indeterminate colitis for up to 5 years. Researchers will collect data on how patients respond to treatments, side effects, and disease changes in everyday medical practice. The go…

This study looks at whether people with inflammatory bowel disease (IBD) have better outcomes and feel more in control of their health when they can text their medical team and regularly report symptoms via text surveys. About 900 participants will be split into two groups: one g…

This study follows 537 adults with moderate-to-severe ulcerative colitis who are taking or will take Simponi. Researchers are monitoring long-term safety, including serious side effects, cancers, and pregnancy outcomes. No new treatment is being tested; the goal is to better unde…

This study is testing a special temperature probe that can be used during a routine colonoscopy to measure heat in the lining of the colon. The goal is to see if this tool can help detect inflammation in people with inflammatory bowel disease (IBD), including Crohn's disease and …

This study is a long-term registry that follows nearly 5,000 children with inflammatory bowel disease (Crohn's, ulcerative colitis, or indeterminate colitis) to monitor their safety and health over time. Researchers collect information on side effects from treatments like inflixi…