ULCERATIVE COLITIS

This study continues testing etrasimod, a daily oral medication, for adults with moderate to severe ulcerative colitis. It follows participants from previous trials to evaluate long-term safety and effectiveness over up to two years. The goal is to help control this chronic infla…

This study is investigating how well the drug mirikizumab improves the sudden, urgent need to have a bowel movement in adults with moderate-to-severe ulcerative colitis. About 172 participants who have not responded well to other treatments will receive mirikizumab for 36 weeks. …

This study follows people with moderate to severe ulcerative colitis who are already taking the experimental drug ABX464. It aims to check the long-term safety and effectiveness of taking 25mg of ABX464 once daily for up to 54 months. The research will monitor patients for side e…

This study is testing an oral medication called tofacitinib to see if it can help children with moderate to severe ulcerative colitis achieve and maintain remission. It involves about 118 children aged 2 to 18 who haven't responded well to other treatments. The main goal is to se…

This early-stage study is testing whether a patient's own fat-derived stem cells can be safely delivered directly into the arteries supplying the colon to treat ulcerative colitis. It involves 20 adults with moderate-to-severe disease that hasn't improved with at least two standa…

This study is testing an investigational drug called lutikizumab for adults with moderate-to-severe ulcerative colitis, a chronic inflammatory bowel disease. It aims to see if lutikizumab is safe, effective, and works as well as or better than an existing treatment (adalimumab). …

This study is testing whether a personalized type of resistant starch (a plant-based fiber) can help improve gut health in children with Crohn's disease or ulcerative colitis. Researchers want to see if this starch can promote healthier gut bacteria and reduce inflammation. The t…

This study is testing whether taking a common ulcerative colitis (UC) pill in the morning or evening works better to control hidden gut inflammation. It involves 32 adults with stable UC who will try taking their once-daily medication at one time for a month, then switch to the o…

This study aimed to see if adding a daily MitoQ antioxidant capsule to standard treatment could better control ulcerative colitis in children and teens. It planned to test if MitoQ improved symptoms, reduced gut inflammation, and helped patients avoid stronger medications like st…

This study is testing an investigational drug called ALTB-268 for adults with moderate-to-severe ulcerative colitis (UC) whose disease has not improved with at least one other advanced biologic therapy. About 50 participants will receive weekly injections of ALTB-268 for 12 weeks…

This large, late-stage study is testing an investigational drug called tulisokibart (MK-7240) for people with moderate to severe ulcerative colitis. It aims to see if the drug is better than a placebo at getting people into clinical remission, both in the short term (12 weeks) an…

This study is testing whether transferring healthy gut bacteria from a donor (fecal microbiota transplantation) can help people with ulcerative colitis. Researchers will enroll 30 patients aged 10-80 to see if this treatment provides long-term relief and is safe. The goal is to r…

This large, late-stage trial is testing whether a daily pill called ABX464 can safely keep ulcerative colitis under control long-term. It involves over 1,100 adults whose disease remains active despite trying standard medications. The study will measure if the drug can keep patie…

This study is testing an investigational drug called GS-1427 to see if it can help control the symptoms of moderate to severe ulcerative colitis. It will involve 228 adults whose current treatments aren't working well enough. Participants will receive either the drug or a placebo…

This study is observing how well the drug filgotinib works and how safe it is for adults with moderate to severe ulcerative colitis in everyday medical practice. It will follow 509 patients for up to two years to see how long they stay on the treatment and if it improves their sy…

This study is testing whether following a gluten-free diet can help control symptoms and slow the progression of two related diseases: primary sclerosing cholangitis (a serious liver disease) and ulcerative colitis (a type of inflammatory bowel disease). Researchers will enroll 6…

This study is testing if a special, personalized type of plant-based starch can help control inflammatory bowel diseases (IBD) like Crohn's and ulcerative colitis in children. Researchers want to see if this starch, tailored to each child's gut bacteria, can reduce gut inflammati…

This study is testing whether a smartphone app and special 'smart' labels can help people with Crohn's disease or ulcerative colitis remember to take their medication. About 123 adults starting a new pill or injection treatment will use the app for a year. The goal is to see if t…

This large study is testing whether an injectable medication called guselkumab can help control symptoms and promote healing in adults with moderate-to-severe ulcerative colitis. Over 1,000 participants will receive either the drug or a placebo to see if it reduces bowel urgency,…

This study is testing whether regular text message check-ins and direct messaging with a medical team helps people with Crohn's disease or ulcerative colitis feel more confident managing their condition and achieve better health outcomes. It will involve 900 teenagers and adults …

This study is testing whether Aquamin, a natural mineral supplement made from red seaweed, can help people with mild ulcerative colitis. Researchers want to see if it improves symptoms, helps patients stay in remission longer, and reduces gut inflammation. The study involves 40 p…

This early-stage study is testing a new oral treatment called CP101, which contains specific gut bacteria, in people with mild-to-moderate ulcerative colitis. The main goals are to see if the treatment safely establishes itself in the gut and if it helps control the disease. Abou…

This study is testing the safety and effectiveness of the drug upadacitinib for children with moderate-to-severe ulcerative colitis who haven't responded well to other standard treatments. About 110 children worldwide will take the medication daily and be closely monitored for ov…

This study is testing an investigational drug called rosnilimab for people with moderate to severe ulcerative colitis (UC) who haven't gotten enough relief from other standard treatments. About 132 participants will be randomly assigned to receive either the drug or a placebo (in…

This study is testing whether transferring healthy gut bacteria from a donor (a fecal microbiota transplant) can help people with ulcerative colitis. It will involve 150 adults with active colitis who are also taking steroid medication. Researchers want to see if this procedure c…

This study is testing whether adding hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) to standard treatment helps people with severe, hard-to-treat ulcerative colitis. Researchers will compare two groups of 44 patients to see if the oxygen therapy leads …

This study is following up with over 1,000 people who have moderate to severe ulcerative colitis to see how well the drug mirikizumab works and how safe it is over three years. It is an extension study, meaning participants are continuing treatment from earlier trials. The main g…

This study is testing a new drug called BI 3032950 for adults with moderate to severe ulcerative colitis who haven't gotten better with other treatments. Participants first receive the drug through an IV every 4 weeks for 12 weeks, then switch to under-the-skin injections for up …

This study is testing if atorvastatin, a common cholesterol-lowering drug, can help prevent colon cancer in people with long-term ulcerative colitis who have a specific genetic change. It involves 42 adults who will take either atorvastatin or a placebo pill daily for one year. R…

This study aims to determine whether taking fewer random tissue samples during colonoscopy is just as effective at finding precancerous growths in people with long-term inflammatory bowel disease. Researchers will compare two different biopsy approaches in over 1,600 patients und…

This study is collecting long-term health information from nearly 5,000 children and teenagers with Crohn's disease, ulcerative colitis, or other inflammatory bowel diseases. Researchers will follow participants for up to 20 years to understand the safety of treatments and how th…

This study is creating a large, long-term registry of patients with Crohn's disease or ulcerative colitis to learn how these conditions behave and how treatments perform in everyday clinic settings. It will follow 15,000 adults and children (age 2+) for five years, collecting inf…

This study is observing adults with moderate-to-severe ulcerative colitis who are already taking either Simponi or thiopurine medications. Researchers are tracking side effects, hospital visits, and how the disease affects daily life and work over time. The goal is to better unde…

This study is collecting information about how Brazilian patients with Crohn's disease or ulcerative colitis use the medication vedolizumab. Researchers are reviewing existing treatment records from about 1006 patients to understand how long they stay on treatment and what outcom…