New hope for kids with severe bowel disease

NCT ID NCT04624230

Ongoing Disease control Sponsor: Pfizer Source: ClinicalTrials.gov ↗

Summary

This study is testing an oral medication called tofacitinib to see if it can help children with moderate to severe ulcerative colitis achieve and maintain remission. It involves about 118 children aged 2 to 18 who haven't responded well to other treatments. The main goal is to see if the drug can significantly reduce disease activity and symptoms over a 44-week period.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

A.O.U. Federico II

Naples, Naples, 80131, Italy
ASST Papa Giovanni XXIII Epatologia e Gastroenterologia Pediatrica e dei Trapianti

Bergamo, BG, 24127, Italy
Aichi Children's Health and Medical Center

Obu-shi, Aichi-ken, 474-8710, Japan
Amsterdam University Medical Center, VUmc Boelelaan

Amsterdam, North Holland, 1105 AZ, Netherlands
Atlantic Children's Health-Pediatric Gastroenterology & Nutrition

Morristown, New Jersey, 07960, United States
Atlantic Health System- Morristown Medical Center (Pharmacy)

Morristown, New Jersey, 07962, United States
Azienda Ospedaliero - Universitaria Policlinico Umberto I di Roma

Roma, RM, 00161, Italy
Azienda USL di Bologna - IRCCS ISNB - Programma Gastroenterologia Pediatrica

Bologna, 40133, Italy
Bart's Health NHS Trust

London, E1 1BB, United Kingdom
Birmingham Women's and Children's NHS Foundation Trust

Birmingham, WEST Midlands, B4 6NH, United Kingdom
Boston Children's Hospital

Boston, Massachusetts, 02115, United States
British Columbia Children's Hospital

Vancouver, British Columbia, V6H 3N1, Canada
Buerger Center for Advanced Pediatric Care

Philadelphia, Pennsylvania, 19104, United States
CHU Sainte-Justine

Montreal, Quebec, H3T 1C5, Canada
CHU de Lyon - Hôpital Femme Mère Enfant

Bron, 69677, France
Center for Advanced Pediatrics

Atlanta, Georgia, 30329, United States
Children's Healthcare of Atlanta - Arthur M. Blank Hospital

Atlanta, Georgia, 30329, United States
Children's Hospital Los Angeles

Los Angeles, California, 90027, United States
Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, 19104, United States
Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio, 45229, United States
Cliniques Universitaires Saint-Luc

Brussels, 1200, Belgium
Connecticut Children's Ambulatory Surgical Center

Farmington, Connecticut, 06032, United States
Connecticut Children's Infusion Center

Farmington, Connecticut, 06032, United States
Connecticut Children's Medical Center

Hartford, Connecticut, 06106, United States
Debreceni Egyetem Klinikai Kozpont

Debrecen, Hajdú-Bihar, 4032, Hungary
Dr. von Haunersches Kinderspital, LMU

Munich, Bavaria, 80337, Germany
Erasmus Medical Center - Sophia Children's Hospital

Rotterdam, 3015 GD, Netherlands
Goryeb Children's Hospital (Endoscopy only)

Morristown, New Jersey, 07960, United States
Gunma University Hospital

Maebashi, Gunma, 371-8511, Japan
Hôpital Necker Enfants Malades

Paris, 75015, France
Hôpital Universitaire Des Enfants Reine Fabiola

Brussels, 1020, Belgium
IWK Health Centre

Halifax, Nova Scotia, B3K 6R8, Canada
Instytut "Centrum Zdrowia Matki Polki"

Lodz, 93-338, Poland
Instytut "Pomnik - Centrum Zdrowia Dziecka"

Warsaw, 04-730, Poland
Jichi Medical University Hospital

Shimotsuke, Tochigi, 329 0498, Japan
Juntendo University Hospital

Bunkyo-ku, Tokyo, 113-8431, Japan
Karolinska Universitetssjukhuset Barngastroenterologi, hepatologi och nutrition

Stockholm, 171 76, Sweden
King's College Hospital NHS Foundation Trust

London, Greater London, SE5 9RS, United Kingdom
Korczowski Bartosz, Gabinet Lekarski

Rzeszów, 35-302, Poland
Kurume University Hospital

Kurume-shi, Fukuoka, 830-0011, Japan
Lady Davis Carmel Medical Center

Haifa, 3436212, Israel
London Health Sciences Centre - Children's Hospital

London, Ontario, N6A 5W9, Canada
London Health Sciences Centre - Children's Hospital

London, Ontario, N6C2R5, Canada
Medical Network Spółka z o.o. WIP Warsaw IBD Point Profesor Kierkuś

Warsaw, Masovian Voivodeship, 04-501, Poland
Miyagi Children's Hospital

Sendai, Miyagi, 989-3126, Japan
NHS Lothian

Edinburgh, EH16 4TJ, United Kingdom
Narodny ustav detskych chorob

Bratislava, 833 40, Slovakia
National Center for Child Health and Development

Setagaya-ku, Tokyo, 157-8535, Japan
Nicklaus Children's Hospital

Miami, Florida, 33155, United States
Northwell Health - Cohen Children's Medical Center

Lake Success, New York, 11042, United States
Northwell Health - Cohen Children's Medical Center

New Hyde Park, New York, 11040, United States
Osaka Medical and Pharmaceutical University Hospital

Takatsuki-shi, Osaka, 569-8686, Japan
Osaka Women's and Children's Hospital

Izumi, Osaka, 594-1101, Japan
Roberts Center for Pediatric Research

Philadelphia, Pennsylvania, 19146, United States
Sachsska Children's and Youth Hospital/South General Hospital

Stockholm, 118 83, Sweden
Sahlgrenska Universitetssjukhuset

Gothenburg, 416 50, Sweden
Saitama Prefectural Children's Medical Center

Saitama-shi, Saitama, 330-8777, Japan
Schneider Children's Medical Center of Israel

Petah Tikva, 4920235, Israel
Seattle Children's Hospital

Seattle, Washington, 98105, United States
Shaare Zedek Medical Center

Jerusalem, 9103102, Israel
Shamir Medical Center (Assaf Harofeh)

Be’er Ya‘aqov, 7033001, Israel
Stollery Children's Hospital University of Alberta

Edmonton, Alberta, T6G 1C9, Canada
Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont

Szeged, 6720, Hungary
Tampereen yliopistollinen sairaala

Tampere, 33520, Finland
Tel-Aviv Sourasky Medical Center

Tel Aviv, 6423906, Israel
Texas Children's Hospital

Houston, Texas, 77030, United States
The Hospital for Sick Children - Division of Gastroenterology, Hepatology and Nutrition

Toronto, Ontario, M5G 1X8, Canada
The Royal Children's Hospital

Parkville, Victoria, 3052, Australia
Universitair Ziekenhuis Brussel

Brussels, 1090, Belgium
Universitaire Ziekenhuizen Leuven

Leuven, Vlaams Brabant, 3000, Belgium
University of California, San Francisco Benioff Children's Hospital

San Francisco, California, 94158, United States
University of California, San Francisco Pediatric Clinical Research Center (PCRC)

San Francisco, California, 94158, United States
Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wroclawiu

Wroclaw, 50-369, Poland

Conditions

Explore the condition pages connected to this study.

ULCERATIVE COLITIS