New pill could tame stubborn ulcerative colitis

NCT ID NCT06254950

Ongoing Disease control Sponsor: Takeda Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests an oral drug called TAK-279 (Zasocitinib) in 207 adults with moderate-to-severe ulcerative colitis. Participants take either the drug or a placebo for 12 weeks, then everyone gets the drug for up to a year. The goal is to see if TAK-279 reduces bowel inflammation and symptoms better than a placebo.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

TAK-279 (also called Zasocitinib), an oral capsule

What this could lead to

If successful, this could provide a new oral treatment option for people with moderate-to-severe ulcerative colitis who haven't responded to other therapies.

What could go wrong

This is an early Phase 2 trial with only 207 participants, so results may not apply to everyone. The drug may not work better than placebo, and side effects are still being studied.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

ulcerative colitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ULCERATIVE COLITIS

Contacts and locations

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Locations

Aalborg Hospital

Aalborg, 9100, Denmark
Accout Center, s.r.o.- Gastroenterologicka ambulancia

Šahy, 936 01, Slovakia
Acibadem City clinic Tokuda hospital

Sofia, 1407, Bulgaria
Addenbrooke's Hospital - Cambridge University Hospitals NHS Foundation Trust

Cambridge, CB2 0QQ, United Kingdom
Agaplesion Markus Krankenhaus

Frankfurt am Main, 60431, Germany
Akershus University Hospital

Lorenskog, Akershus, 1478, Norway
Asan Medical Center (AMC)

Seoul, 5505, South Korea
Assuta Ashdod University Hospital

Ashdod, 7747629, Israel
Atlanta Center For Gastroenterology, P.C.

Decatur, Georgia, 30033, United States
Auzmer Research

Lakeland, Florida, 33813, United States
Axon Clinical s.r.o.

Prague, 15000, Czechia
Azienda Ospedaliera Ospedali Riuniti Villa Sofia Cervello

Palermo, 90146, Italy
Azienda Ospedaliera San Camillo Forlanini

Rome, 152, Italy
CHU De Clermont Ferrand - Hopital Estaing

Clermont-Ferrand, 63000, France
Centre Hospitalier Regional Universitaire de Nancy Hopital Brabois

Vandœuvre-lès-Nancy, 54500, France
Centre Hospitalier de l'Universite de Montreal

Montreal, Quebec, H2X 0A9, Canada
Centrum Medyczne MedykSp. z o.o. Sp. K.

Rzeszów, 35-326, Poland
Centrum Medyczne Melita Medical

Wroclaw, Dolnolskie, 50-449, Poland
Changhua Christian Hospital (CCH)

Changhua, Changhua County, 50006, Taiwan
China Medical University (CMU) - Shengjing Hospital (The Second Affiliated Hospital) - Huaxiang Campus

Shenyang, Liaoning, 110022, China
China Medical University Hospital

Taichung, 40447, Taiwan
Chongqing General Hospital

Chongqing, Chongqing Sheng, 401147, China
Clinexpert

Budapest, 1033, Hungary
Clinical Hospital Colentina-Spitalul Clinic Colentina

Bucharest, 0 50159, Romania
Clinical Research Centre - Barts Health NHS Trust

London, E1 2at, E1 2AT, United Kingdom
Cliniq s. r. o.

Bratislava, 811 09, Slovakia
Concord Repatriation General Hospital

Sydney, New South Wales, 2139, Australia
Delta Health Care

Bucharest, 14142, Romania
Diagnostic-Consultative Center Aleksandrovska EOOD

Sofia, 1431, Bulgaria
Emory University Hospital, The Emory Clinic

Atlanta, Georgia, 30322, United States
EndoArt

Ostrava, 71000, Czechia
Endohope Clinic

Prague, 10100, Czechia
Endomed

Košice, 4013, Slovakia
Evaggelismos Hospital (Evangelismos Hospital)-University of Athens

Athens, Attica, 106 76, Greece
Fakultna Nemocnica s poliklinikou Nove Zamky

Nové Zámky, 94034, Slovakia
Fakultna nemocnica F. D. Roosevelta

Banská Bystrica, 97401, Slovakia
Fakultni Nemocnice Ostrava (FNO)

Ostrava-Poruba, 708 00, Czechia
Flinders Medical Centre

Bedford Park, South Australia, 5042, Australia
Fraser Clinical Trials

New Westminster, British Columbia, V3L 3W4, Canada
Fukuoka University Hospital

Fukuoka, 814-0180, Japan
G.N.A. Gennimatas

Athens, 15669, Greece
GI PROS, Inc.

Naples, Florida, 34102, United States
GastroIntestinal BioSciences

Los Angeles, California, 90067, United States
Gastroenterology Associates, PA

Greenville, South Carolina, 29607, United States
Gastromed Kopon, Zmudzinski i Wspolnicy Sp.j. Specjalistyczne Centrum Gastrologii i Endoskopii Specjalistyczne Gabinety Lekarskie

Torun, Kujawsko-pomo, 87-100, Poland
Gastromedic s.r.o

Pardubice, 530 03, Czechia
H-T. Centrum Medyczne Sp. z o.o. Sp.k.

Tychy, 43-100, Poland
Hamburger Forschungsinstitut Fuer Chronisch Entzuendliche Darmerkrankungen (HaFCED e.K.)

Hamburg, 20251, Germany
Harry Perkins Medical Research Institute Fiona Stanley Hospital

Murdoch, 6150, Australia
Hepato-Gastroenterologie HK, s.r.o.

Hradec Králové, 50012, Czechia
Heritage Medical Research Clinic - University Of Calgary

Calgary, Alberta, T2N 4Z6, Canada
Hillerod Hospital, Hilleroed Sygehus

Hillerød, 3400, Denmark
Hopital Nord Chu Saint-Etienne

Saint-Etienne, 42055, France
Hopital Universitaire de Bruxelles/ Academisch Ziekenhuis Burssel

Brussels, Anderlecht / Region Capitale de Bruxelles/ Brussel, 1070, Belgium
Hopital l'Archet 2

Nice, 6202, France
Hvidovre Hospital Medicinsk Gastroenterologisk Afdeling

Hvidovre, 2650, Denmark
IRCCS A.O.U. Policlinico S. Orsola - Malpighi

Bologna, 40138, Italy
IRCCS Istituto clinico humanitas - Humanitas Mirasole spa

Rozzano, 20089, Italy
Inje University Haeundae Paik Hospital

Busan, 48108, South Korea
Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) - Ospedale San Raffaele Hospital

Milan, 20132, Italy
Javorszky Odon Korhaz

Vác, 2600, Hungary
Kansai Medical University Hospital

Hirakata, Osaka, 5731191, Japan
Kitasato University Kitasato Institute Hospital

Minato-ku, Tokyo, 108-8642, Japan
Korczowski Bartosz, Gabinet Lekarski

Rzeszów, 35302, Poland
Kyorin University Hospital

Mitaka, Tokyo, 181-8611, Japan
Las Vegas Medical Research

Las Vegas, Nevada, 89113, United States
London Health Sciences Centre - University Hospital

London, Ontario, N6A 5A5, Canada
London Health Sciences Centre - Victoria Hospital

London, Ontario, N6A 5W9, Canada
Masaryk Hospital

Ústí nad Labem, 40113, Czechia
Mater Cancer Care Centre-Mater Health Services

South Brisbane, Queensland, 4101, Australia
Medrise sp. z o.o

Lublin, 20-582, Poland
Mohacsi Korhaz

Mohács, 7700, Hungary
Monza-Ares Srl

Bucharest, Sector 2, 021967, Romania
NH Hospital

Hořovice, Central Bohemia, 268 31, Czechia
National Taiwan University Hospital (NTUH)

Taipei, Zhongzheng District, 100, Taiwan
Novel Research, LLC

Bellaire, Texas, 77401, United States
Oddzial Kliniczny Gastroenterologii Ogolnej i Onkologicznej SPZOZ Uniwersytecki Szpital Kliniczny Nr 1 im. Barlickiego Uniwersytetu Medycznego w Lodzi

Lodz, 90-153, Poland
Odense Universitetshospital (OUH) (Odense University Hospital)

Odense, Region Syddanmark, 5000, Denmark
Oslo Univeristy Hospital Ulleval Hospital

Oslo, 450, Norway
Pannonia Maganorvosi Centrum Kft.

Budapest, 1136, Hungary
Panstwowy Instytut Medyczny MSWiA

Warsaw, Masovian Voivodeship, 02-507, Poland
Pecs University Clinical Center Mohacs Hospital

Sofia, 1000, Bulgaria
PlanetMed Sp. z o.o.

Wroclaw, Lower Silesian Voivodeship, 52-210, Poland
Policlinica Algomed: Centrul De Gastroenterologie Dr. Goldis

Timișoara, Jud Timis, 300002, Romania
Praxis fur Gastroenterologie

Heidelberg, 69115, Germany
Region Sjaelland Sygehus Nord, Koge Sygehus

Køge, 4600, Denmark
Renji hospital shanghai jiao tong university school of medicine

Shanghai, Shanghai Municipality, China
Royal Perth Hospital

Perth, Western Australia, 6000, Australia
Saga University Hospital

Saga, 849-0937, Japan
Samsung Medical Center

Seoul, 6351, South Korea
Sapporo Medical University Hospital

Sapporo, Hokkaido, 060-8543, Japan
Semmelweis Egyetem

Budapest, 1082, Hungary
Severance Hospital, Yonsei University Health System

Seoul, 3722, South Korea
Shaare Zedek Medical Center

Jerusalem, 9103102, Israel
Shanghai Pudong New District Zhoupu Hospital

Shanghai, 201318, China
Sir Charles Gairdner Hospital Lung Institute Of Western Australia

Nedlands, Western Australia, 6009, Australia
Soroka Mc

Beersheba, 84101, Israel
Sotiria General Hospital of Athens

Athens, 11527, Greece
South Eastern Health and Social Care Trust - The Ulster Hospital

Belfast, BT16 1RH, United Kingdom
Spital Clinic Dr I Cantacuzino

Bucharest, 20475, Romania
Spitalul de Oncologie Monza - Soseaua Gheorghe Ionescu Sisesti

Bucharest, 13823, Romania
St Thomas' Hospital - Guy's & St Thomas' NHS Foundation Trust

London, SE1 7EH, United Kingdom
St. Marien- und St. Annastiftskrankenhaus

Ludwigshafen, 67065, Germany
Sun Yat-sen University - The Sixth Affiliated Hospital (Guangdong Gastrointestinal Hospital)

Guangzhou, Guangdong, 3011, China
SurGal Clinic SRO

Brno, 602 00, Czechia
Sydvestjysk Region/Esbjerg Hospital

Esbjerg, 6700, Denmark
Szpital Uniwersytecki nr 2 im. Dr Jana Biziela w Bydgoszczy

Bydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-168, Poland
The Alfred Hospital

Melbourne, Victoria, 3004, Australia
The Chaim Sheba Medical Center - The Edmond and Lily Safra Children's Hospital

Ramat Gan, 5265601, Israel
The Queen Elizabeth Hospital

Woodville, South Australia, 5011, Australia
The Research Institute of the McGill University Health Center

Montreal, Quebec, H3G 1A4, Canada
The Second People's Hospital of Changzhou

Changzhou, Jiangsu, 200001, China
The Second Xiangya Hospital of Central South University

Changsha, Hunan, 410011, China
The jikei University Hospital

Minato, Tokyo, 105-8471, Japan
Toho University Sakura Medical Center

Sakura, Chiba, 285-8741, Japan
Twoja Przychodnia - Szczecinskie Centrum Medyczne

Szczecin, West Pomeranian Voivodeship, 71-434, Poland
Tyler Research Institute, LLC

Tyler, Texas, 75701, United States
UMBAL Kaspela

Plovdiv, 4001, Bulgaria
USF Health Morsani Center for Advanced Healthcare

Tampa, Florida, 33612, United States
United Medical Doctors

Murrieta, California, 92563, United States
Universitaetsklinikum Schleswig-Holstein, UKSH-Campus Kiel

Kiel, 24105, Germany
Universitaetsklinikum Tuebingen

Tübingen, 72076, Germany
Universitair Ziekenhuis Leuven

Leuven, 3000, Belgium
University Gastroenterology

Providence, Rhode Island, 02904, United States
University General Hospital of Patras

Pátrai, Achaia, 26504, Greece
University Hospital Brno

Brno, 639 00, Czechia
University Hospital City Clinic Cancer Center

Sofia, 1784, Bulgaria
University Hospital Of Ulm, Universitatsklinikum Ulm

Ulm, 89081, Germany
University Hospital Tsaritsa Yoanna - Isul (University Hospital Queen Giovanna)

Sofia, 1527, Bulgaria
University Hospital of Heraklion

Heraklion, Crete, 71110, Greece
University Of Louisville

Louisville, Kentucky, 40202, United States
University of Washington Medical Center

Seattle, Washington, 98195, United States
Vojenska Nemocnice Brno

Brno, 636 00, Czechia
WIP Warsaw IBD Point Profesor Kierkus

Warsaw, 04-501, Poland
West Central Gastroenterology, LLP, d/b/a/ Gastro Florida

Clearwater, Florida, 33762, United States
West China Hospital of Sichuan University

Chengdu, Sichuan, 610041, China
Western Health/Footscray Hospital

Melbourne, Victoria, 3011, Australia
Woodholme Gastroenterology Associates

Glen Burnie, Maryland, 21061, United States
Wuhan University - Renmin Hospital (Hubei General Hospital)

Chongqing, Hubei, 430060, China
Yonsei University Wonju Severance Christian Hospital

Wŏnju, Gangwon-do, 26426, South Korea
Zhejiang University School of Medicine - Sir Run Run Shaw Hospital (SRRSH)

Hangzhou, 310016, China