New hope for tough ulcerative colitis cases? experimental drug ALTB-268 enters phase 2 trial

NCT ID NCT06109441

Ongoing Disease control Sponsor: AltruBio Inc. Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This Phase 2a trial is testing an injectable biologic drug called ALTB-268 in 50 adults with moderately to severely active ulcerative colitis that has not improved with other biologic therapies. The study is open-label, meaning everyone receives the drug, and will measure changes in disease activity over 12 weeks. The goal is to see if ALTB-268 can reduce symptoms and inflammation, offering a potential new option for patients with hard-to-treat disease.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ALTB-268 (an injectable biologic drug)
What this could lead to: If successful, this could point toward a new treatment option for people with ulcerative colitis who haven't responded to other biologic therapies.
What could go wrong: This is an early, small, open-label study (no placebo group), so results may not be definitive. The drug may not work or could have side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

ulcerative colitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ULCERATIVE COLITIS

Contacts and locations

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Locations

Alliance Clinical Research of Tampa, LLC.

Tampa, Florida, 33615, United States
Caprock Gastro Reasearch

Lubbock, Texas, 19424, United States
DHAT / GI Aliance

Garland, Texas, 75044, United States
Dayton Gastroenterology, LLC

Beavercreek, Ohio, 45440, United States
Digestive Disease Medicine of Central New York

Utica, New York, 13502, United States
Digestive and Liver Center of Florida, LLC

Orlando, Florida, 32825, United States
Frontier Clinical Research, LLC

Uniontown, Pennsylvania, 15401, United States
GI Alliance

Mansfield, Texas, 760603, United States
GI Alliance

Webster, Texas, 33016, United States
Gastro Health Ohio

Liberty Township, Ohio, 45044, United States
Gastro Health Partners Louisville

Louisville, Kentucky, 40218, United States
Gastro Health Partners Southern Indiana

New Albany, Indiana, 47150, United States
Gastro Health Research

Miami, Florida, 33176, United States
Gastroenterology Associates of North Mississippi

Oxford, Mississippi, 38655, United States
Gastroenterology Associates, P.A.

Greenville, South Carolina, 29607, United States
Gastroenterology Group of Rochester

Rochester, New York, 14618, United States
Louisiana Research Center, LLC.

Shreveport, Louisiana, 71105, United States
New York Presbyterian Hospital - Weill Cornell Medical Colllege

New York, New York, 10065, United States
Rocky Mountain Gastroenterology

Littleton, Colorado, 80120, United States
San Diego Gastroenterology

San Diego, California, 92103, United States
Southern Star Research Institute LLC

San Antonio, Texas, 78229, United States
Tyler Research Institute

Tyler, Texas, 75701, United States
Wellness Clinical Research, LLC

Vega Baja, 00693, Puerto Rico
Wisconsin Center for Advanced Research

Milwaukee, Wisconsin, 53215, United States

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