Do extra biopsies during colonoscopy help IBD patients? major study aims to find out

NCT ID NCT06560021

ENROLLING_BY_INVITATION Knowledge-focused Sponsor: Abramson Cancer Center at Penn Medicine Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether taking extra random biopsies during a colonoscopy helps find precancerous growths in people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. About 1,600 participants will be randomly assigned to one of two biopsy methods and followed for up to 15 years. The goal is to improve cancer prevention while reducing unnecessary procedures.

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Conditions

The condition(s) this trial relates to.

Crohn disease indeterminate colitis inflammatory bowel disease ulcerative colitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CROHN DISEASE INFLAMMATORY BOWEL DISEASES ULCERATIVE COLITIS

Contacts and locations

Locations

AdventHealth

Orlando, Florida, 32804, United States
Allegheny Health Network

Pittsburgh, Pennsylvania, 15224, United States
Houston Methodist Hospital

Houston, Texas, 77030, United States
Icahn School of Medicine at Mount Sinai

New York, New York, 10029, United States
Mayo Clinic Jacksonville

Jacksonville, Florida, 32224, United States
Mayo Clinic Rochester

Rochester, Minnesota, 55905, United States
Mercy Medical Center

Baltimore, Maryland, 21202, United States
NYU Langone Health

New York, New York, 10016, United States
Northwestern University

Chicago, Illinois, 60611, United States
Scripps Health

San Diego, California, 92121, United States
University of Alabama Birmingham

Birmingham, Alabama, 35233, United States
University of California, Los Angeles

Los Angeles, California, 90095, United States
University of Colorado

Aurora, Colorado, 80045, United States
University of Miami

Miami, Florida, 33136, United States
University of Michigan

Ann Arbor, Michigan, 48109, United States
University of North Carolina

Chapel Hill, North Carolina, 27599, United States
University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States
University of Pittsburgh

Pittsburgh, Pennsylvania, 15213, United States
University of Rochester

Rochester, New York, 14642, United States
University of Utah

Salt Lake City, Utah, 84112, United States

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