New Stomach-Slimming procedure tested for ulcerative colitis patients
NCT ID NCT05739162
First seen Jun 27, 2026 · Last updated Aug 07, 2026 · Updated 4 times
Summary
This study is testing a minimally invasive weight loss procedure called endoscopic sleeve gastroplasty (ESG) in 12 people who have both obesity and ulcerative colitis and are planning or have had colon removal surgery. The procedure uses a suturing device to reduce stomach size by 70-80%, and participants also follow a personalized low-calorie diet and exercise plan. The goal is to see if ESG is safe and effective for weight loss in this specific group.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Endoscopic sleeve gastroplasty (ESG) using the Apollo Endoscopic Suture System, plus a personalized low-calorie diet and physical activity plan
- What this could lead to
- If it works, this could offer a safe weight-loss option for obese UC patients before or after colon removal surgery, potentially reducing surgical complications.
- What could go wrong
- This is a very small early study (12 people) with no control group, so results may not apply broadly. The procedure carries risks like bleeding or infection, and weight loss may not be sustained.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Mayo Clinic Minnesota
Rochester, Minnesota, 55905, United States
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