ULCERATIVE COLITIS

This early-stage study tested a new treatment called MB310 in 29 adults with mild-to-moderate ulcerative colitis. The main goal was to see if it is safe and how well it settles in the body. Researchers also looked for early signs that it might help control the disease.

This study looked at the long-term safety and effectiveness of the drug vedolizumab (Entyvio) in over 1,100 people with moderate to severe ulcerative colitis who had not responded well to other treatments. Researchers tracked side effects and how well the drug controlled the dise…

This study tested a daily pill called ABX464 in 217 adults with moderate to severe ulcerative colitis who had already completed 16 weeks of treatment. The goal was to see if the drug could keep the disease in remission for up to 96 weeks. Researchers measured remission using a st…

This study tested whether mirikizumab can help people with moderate to severe ulcerative colitis stay in remission. About 1,300 adults who improved during an earlier 12-week treatment period were given either mirikizumab or a placebo for up to 40 weeks. The goal was to see if the…

This study involved 38 adults with inflammatory bowel disease (Crohn's or colitis) whose disease was under control with intravenous (IV) infliximab. Researchers switched them to a subcutaneous (under-the-skin) version of the same medication to see if drug levels, effectiveness, a…

This study looked at the long-term safety of the drug vedolizumab in 59 children (ages 2-17) with ulcerative colitis or Crohn's disease. The main goal was to track any side effects that occurred during treatment. The study found that vedolizumab was generally safe for long-term u…

This study tested an experimental daily pill called ABX464 in 355 adults with moderate to severe ulcerative colitis who had not responded well to other treatments. The goal was to see if the drug could reduce symptoms like diarrhea, bleeding, and colon inflammation compared to a …

This study tested whether fecal transplants from healthy donors could help people with ulcerative colitis, a chronic gut condition. 85 adults received either donor or their own stool via a tube and enemas. The goal was to see if donor transplants could reduce symptoms and heal th…

This study looked at the long-term safety of a drug called adalimumab in children with ulcerative colitis, a disease that causes inflammation in the colon. 59 children who had already completed a previous study took the drug for up to 2 years. The goal was to see if it was safe a…

This study looked at whether probiotics (good bacteria) can help people with ulcerative colitis stay in remission. Researchers followed 70 adults in Egypt for one year, checking their disease activity, body weight, and gut bacteria. The goal was to see if changing the gut microbi…

This study tested an experimental drug called ABBV-668 in 30 adults with moderate to severe ulcerative colitis, a condition causing inflammation and bleeding in the colon. Participants took the drug twice daily for 16 weeks. The goal was to see if it could improve colon healing a…

This study tested whether rutin, a natural compound found in plants, can reduce inflammation and improve symptoms in people with ulcerative colitis. Sixty adults with confirmed UC took rutin to see if it could lower disease activity by targeting a specific inflammatory pathway. T…

This study looked at how safe and effective the drug Rinvoq is for adults with moderate to severe ulcerative colitis. About 300 people in Japan took Rinvoq as part of their regular care and were followed for up to 60 weeks. The main goal was to track serious infections and other …

This study looked at the long-term safety and effectiveness of an oral medication called RPC1063 for people with moderate to severe ulcerative colitis. It included 877 participants who had already taken the drug in earlier studies. The main goal was to track side effects, and res…

This study looked at how safe and effective the drug upadacitinib (RINVOQ) is for Korean adults with moderate to severe ulcerative colitis or Crohn's disease. About 105 patients took the drug as prescribed by their doctor and were followed for up to 52 weeks. The main goal was to…

This study tested a new approach for people newly diagnosed with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. Researchers used a blood test that measures proteins to identify patients at high risk for a worse disease course. These high-risk …

This study tested whether a web-based telemonitoring system (TECCU) helps people with moderate-to-severe inflammatory bowel disease (Crohn's disease or ulcerative colitis) stay in remission longer than standard care. 290 adults who needed immunosuppressants or biologics were foll…

This study followed 152 adults with moderate to severe ulcerative colitis for two years to see if tofacitinib helps control symptoms in real-life settings. Researchers measured symptom relief, like stopping rectal bleeding and normalizing bowel movements, one and two years after …

This study tested whether the drug mirikizumab can help people with moderate to severe ulcerative colitis whose gut inflammation has not improved with standard treatments. About 100 adults took part, and researchers measured changes in symptoms and inflammation using colonoscopie…

This study tested a new daily pill, ABX464, in 636 adults with moderate-to-severe ulcerative colitis who had not responded well to other treatments. The goal was to see if the drug could help achieve remission and improve the lining of the colon after 8 weeks, compared to a place…

This study tested an oral medication called amiselimod (MT-1303) in 322 adults with mild to moderate ulcerative colitis. Participants received either the drug or a placebo for 12 weeks to see if it improved symptoms like diarrhea and rectal bleeding, followed by an open-label per…

This study tested a daily pill called ABX464 in 639 adults and teens with moderate to severe ulcerative colitis who had not responded well to other treatments. The goal was to see if the drug could safely help patients achieve remission (symptom relief and bowel healing) after 8 …

This early-phase study tested whether a bile acid supplement called TUDCA is safe and can reduce stress in gut cells of people with active ulcerative colitis. Fourteen adults with mild to moderate disease took TUDCA for 6 weeks. Researchers measured changes in cell stress markers…

This study looked at whether switching from a lower to a higher concentration of adalimumab (AVT-02) reduces injection site pain and improves treatment adherence. It involved 324 adults with conditions like Crohn's disease, rheumatoid arthritis, or psoriasis. Researchers measured…

This study looked at whether a physical activity program could help improve bone density in children and teenagers with inflammatory bowel disease (IBD), such as Crohn's disease or ulcerative colitis. Kids with IBD often have lower bone density due to inflammation, medication, or…

This study looked at whether a short-term, plant-based low-calorie diet (called a fasting mimicking diet) could improve depressive symptoms in people with inflammatory bowel disease (IBD). 42 adults with mild to moderate depression and IBD completed three 5-day diet cycles. Resea…

This small study tested whether a digital wellness app using artificial intelligence and virtual reality could safely provide mental health support to adults with inflammatory bowel disease who also have mild anxiety or depression. Twenty-two participants used the app during a si…

This study tested whether a prebiotic (a type of fiber that feeds good gut bacteria) can improve symptoms in people with mild to moderate ulcerative colitis. 38 adults took either the prebiotic or a placebo for four weeks, then switched. Researchers measured symptom changes, gut …

This study tested a self-management program for people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. The program included eight sessions covering topics like symptom tracking, relaxation, diet, and pain management. Researchers wanted to …

This study looked at whether eating gluten-free can reduce stomach symptoms and tiredness in people with ulcerative colitis. Fifteen adults each spent one week on a gluten-free diet plus a special granola bar, and another week on the same diet but with a high-gluten bar. They rep…

This study looked at whether eating broccoli sprouts could help people with mild ulcerative colitis. Researchers wanted to see if participants could easily add steamed broccoli sprouts to their diet and if it would reduce inflammation in the gut. 23 people with mild ulcerative co…

This study looked at 40 children aged 6 to 17 with inflammatory bowel disease (IBD) to understand how DNA that escapes from cells might worsen inflammation. Researchers analyzed blood, stool, and gut tissue samples to study a specific pathway called cGAS-STING. The goal was to id…

This study looked at 211 adults with long-standing inflammatory bowel disease (IBD) to see which colonoscopy method finds early signs of colon cancer better: high-definition white light or dye-spraying chromo-colonoscopy. Participants had IBD for at least eight years. The goal wa…

This study looked at nearly 24,000 older adults (65+) with ulcerative colitis or Crohn's disease to compare infection risks from three types of advanced treatments: ENTYVIO, TNF-alpha inhibitors, and ustekinumab. Researchers used existing Medicare claims data from 2016 to 2025 to…

This study looked at whether regularly measuring the amount of anti-TNF medication and antibodies in the blood helps doctors make better treatment decisions for people with Crohn's disease or ulcerative colitis. 260 patients were split into two groups: one where doctors had acces…

This early-stage study tested whether an experimental oral drug called MB-001 is safe in healthy adults. 48 participants received either the drug or a placebo in single or multiple doses. Researchers monitored side effects and checked vital signs, lab results, and heart activity.…

This study tested whether a skin patch (transdermal delivery system) can deliver the drug ozanimod as well as the oral capsule (Zeposia) in 24 healthy adults. Participants either took one capsule or wore a patch for 7 days. Researchers measured drug levels in the blood and checke…

This study followed 165 people with inflammatory bowel disease (IBD) in Poland who were already taking or starting vedolizumab. Researchers simply observed whether patients chose intravenous (IV) or subcutaneous (SC) treatment, and how long they stayed on it. No new treatments or…

This study tested whether simple, low-cost blood test ratios (like CRP-to-albumin) can help monitor disease activity in people with ulcerative colitis. Researchers compared these blood markers with standard colonoscopy and stool tests in 80 patients. The goal was to see if these …