ULCERATIVE COLITIS

This study tested whether a web-based monitoring system could help people with complex inflammatory bowel disease (like Crohn's or colitis) stay in remission as well as standard clinic visits. 290 adults in Spain who were already taking strong medications for their condition were…

This study tested whether a daily pill called ABX464 could help people with moderate to severe ulcerative colitis who haven't responded well to other treatments. Researchers compared the pill against a placebo in 639 participants over 8 weeks to see if it could reduce symptoms an…

This study tested an experimental oral medication called ABBV-668 for adults with moderate to severe ulcerative colitis, a chronic inflammatory bowel disease. About 30 participants took capsules twice daily for 16 weeks to see if the drug could reduce intestinal inflammation and …

This small pilot study explored whether adding steamed broccoli sprouts to the diet could help manage mild ulcerative colitis. Researchers tested if eating the sprouts increased certain beneficial compounds in the body and reduced gut inflammation markers. The goal was to see if …

This study monitored 308 adults in Japan with moderate to severe ulcerative colitis who were prescribed Rinvoq by their doctors. The goal was to check the drug's safety and how well it controlled the disease in real-world, everyday medical practice. Participants were followed for…

This study monitored the long-term safety and effectiveness of the drug Entyvio (vedolizumab) in people with moderate to severe ulcerative colitis. It observed over 1,100 patients in Japan who were already receiving the drug as part of their regular care. The goal was to collect …

This early-stage study tested whether TUDCA, a dietary supplement, could help control ulcerative colitis symptoms. Fourteen adults with active ulcerative colitis took TUDCA for six weeks while researchers monitored safety and measured changes in gut inflammation. The goal was to …

This study tested whether rutin, a natural compound found in plants, could help people with ulcerative colitis. Researchers gave rutin to 60 adults with the condition to see if it could reduce gut inflammation and improve symptoms by calming a specific overactive part of the immu…

This study tested whether a skin patch could deliver the drug ozanimod as well as the standard oral capsule. Ozanimod is used to treat multiple sclerosis and ulcerative colitis. Researchers compared how the body absorbed the drug from three different patch formulas versus a swall…

This study tested the long-term safety and effectiveness of an oral medication called RPC1063 for people with moderate to severe ulcerative colitis. It involved 877 participants who had already been in previous RPC1063 trials, allowing them to continue treatment for several more …

This study tested a daily pill called ABX464 to see if it could safely keep ulcerative colitis under control over a long period. It involved 217 people with moderate to severe disease who had already taken the drug in a previous short-term study. The main goal was to see how many…

This small, early-stage study tested the safety of a new treatment called MB310, which is made of specific live bacteria. It involved 29 adults with active, mild-to-moderate ulcerative colitis. The main goal was to see if the treatment was safe and if the bacteria could successfu…

This study tested whether taking probiotics (beneficial bacteria) could help patients with ulcerative colitis, a chronic bowel disease, stay in remission. It involved 70 Egyptian adults whose disease was already under control. Researchers tracked their symptoms and gut bacteria o…

This study tested whether a daily pill called ABX464 could help control moderate-to-severe ulcerative colitis in people who haven't gotten enough relief from standard treatments. Researchers compared the pill to a placebo (inactive pill) in 636 participants over 8 weeks to see if…

This study tested whether the drug Mirikizumab could help patients with moderate to severe ulcerative colitis who were not getting better on their current treatments. It specifically looked at patients who had a high level of inflammation seen during a colonoscopy. The goal was t…

This study tested whether a guided physical activity program could improve bone mineral density in children and teenagers with chronic inflammatory bowel diseases like Crohn's disease and ulcerative colitis. Researchers worked with 15 young patients who had IBD for at least six m…

This study tested whether mirikizumab could help people with moderate to severe ulcerative colitis maintain their improvement after initial treatment. Over 1,100 participants who had responded well to earlier treatment received either the drug or a placebo for 40 weeks. Researche…

This study tested if a special dietary fiber, called a prebiotic, could help control ulcerative colitis by improving gut bacteria and reducing symptoms. Thirty-eight adults with mild to moderate disease took the prebiotic or a placebo powder for four weeks each, and researchers m…

This study observed 152 French adults with moderate-to-severe ulcerative colitis who were prescribed the drug tofacitinib by their doctors. The goal was to see how well the drug controlled their symptoms and improved their quality of life over two years in a real-world setting, o…

This study tested whether a daily oral pill called amiselimod could help adults with mild to moderate ulcerative colitis. For 12 weeks, 322 participants received either the study drug or a placebo pill, and researchers measured changes in bowel symptoms and colon inflammation. Th…

This study tested whether regularly checking the level of anti-TNF drugs in a patient's blood helps manage Crohn's disease and ulcerative colitis more effectively. 260 patients were split into two groups: one where doctors used these blood test results to adjust treatment, and on…

This study looked at whether switching patients with stable Crohn's disease or ulcerative colitis from receiving their infliximab medicine through an IV at a clinic to giving themselves a shot at home was effective. It followed 38 adult patients for 24 weeks after the switch to s…

This study tested whether using a blood test to identify newly diagnosed inflammatory bowel disease (IBD) patients at high risk for severe disease could improve their outcomes. 300 patients were randomly assigned to either have their treatment guided by this blood test result or …

This study monitored Korean adults with moderate to severe ulcerative colitis or Crohn's disease who were prescribed the approved drug upadacitinib (RINVOQ) by their doctor. The goal was to collect real-world information on the drug's safety and how well it controls disease sympt…

This study checked the long-term safety and effectiveness of the drug adalimumab in children and teenagers with ulcerative colitis (UC). It involved 59 young patients who had already taken the drug in a previous trial. The main goal was to see if continued use was safe and if it …

This study tested a new daily pill called ABX464 for people with moderate-to-severe ulcerative colitis who haven't gotten better with standard treatments. It involved 355 patients who took one of three different doses or a placebo pill for 16 weeks. The main goal was to see if th…

This study aimed to understand the long-term safety of a medication called vedolizumab in children and teenagers with ulcerative colitis or Crohn's disease. It followed 59 young participants who had already responded to the drug in a previous trial, monitoring them for side effec…

This study aimed to see if simple ratios calculated from routine blood tests could help doctors monitor how active ulcerative colitis is in a patient. Researchers compared these blood test results against colonoscopy findings, which is the standard way to check disease activity, …

This study compared two standard colonoscopy techniques used to screen for early colon cancer in people who have had inflammatory bowel disease (IBD) for over eight years. Researchers wanted to see if a newer high-definition camera method was as good as an older dye-spraying meth…

This small, exploratory study tested a single session using a virtual reality app with an AI-powered guide to provide mental health support. It involved 22 adults with inflammatory bowel disease (IBD) who also had mild to moderate anxiety or depression. The main goal was to see i…

This study looked at whether switching patients to a higher concentration version of the drug adalimumab (brand name SIMLANDI™) causes less injection site pain than the standard version. It involved 324 adults in Canada who were already using adalimumab for conditions like Crohn'…

This study tested whether a special plant-based, low-calorie 'fasting mimicking' diet could help reduce depression symptoms in people with Crohn's disease or ulcerative colitis (IBD). 42 adult participants with mild-to-moderate depression tried three cycles of the 5-day diet. Res…

This study tested a new self-management program designed to help people with Crohn's disease or ulcerative colitis. The program taught 55 participants strategies for tracking symptoms, managing stress and pain, improving sleep, and adjusting diet. Researchers wanted to see if the…

This study tested whether eating a gluten-free diet could reduce gut symptoms and fatigue in people with ulcerative colitis. Fifteen participants tried one week of a high-gluten diet and one week of a gluten-free diet in a random order. Researchers measured their symptoms and col…

This study aimed to understand why inflammatory bowel diseases (IBD) like Crohn's and colitis are often more severe in children. Researchers tested the idea that DNA leaking from cells might trigger and worsen gut inflammation through a specific biological pathway. They analyzed …

This study observed patients with Crohn's disease or ulcerative colitis in Poland who were receiving vedolizumab treatment, either by IV infusion or a newer under-the-skin injection. Researchers tracked which treatment method patients stayed on longer and why some switched or sto…

This was the first study in people to check if a new oral drug called MB-001 is safe. It was tested in 48 healthy volunteers who took either the drug or a placebo. Researchers measured side effects and how the drug behaved in the body to decide if it's safe to test in patients wi…