Could a bile acid pill ease ulcerative colitis? early trial hints at promise

NCT ID NCT04114292

First seen Mar 11, 2026 · Last updated May 17, 2026 · Updated 10 times

Summary

This early-phase study tested whether a bile acid supplement called TUDCA is safe and can reduce stress in gut cells of people with active ulcerative colitis. Fourteen adults with mild to moderate disease took TUDCA for 6 weeks. Researchers measured changes in cell stress markers from colon biopsies and monitored for side effects. The goal was to see if TUDCA might help control the disease, but more research is needed.

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Contacts and locations

Locations

  • Barnes-Jewish Hospital

    St Louis, Missouri, 63110, United States

  • Barnes-Jewish West County Hospital

    Creve Coeur, Missouri, 63141, United States

  • Washington University School of Medicine

    St Louis, Missouri, 63110, United States

Conditions

Explore the condition pages connected to this study.