Fasting diet shows promise for depression in bowel disease
NCT ID NCT05382897
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study tested whether a low-calorie, plant-based diet that mimics fasting could reduce depressive symptoms in people with inflammatory bowel disease (IBD). 42 adults with mild-to-moderate depression and IBD followed either the fasting-mimicking diet or a calorie-sufficient plant-based diet for three 5-day cycles over three months. Researchers measured changes in mood, gut microbes, and immune function to see if targeting the gut could improve mental health.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- plant-based fasting-mimicking diet
- What this could lead to
- If it works, this could offer a safe, non-drug way to improve mood in people with inflammatory bowel disease.
- What could go wrong
- This was a small, early-stage trial with only 42 participants. The diet is restrictive and may be hard to follow long-term. Results may not apply to everyone.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for CROHN DISEASE are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University of Alberta Hospital
Edmonton, Alberta, T6G 2E1, Canada
-
University of Alberta Human Nutrition Research Unit
Edmonton, Alberta, T6G 2E1, Canada
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Sound waves vs. scope: a gentler way to spot pouch inflammation?
- Can a patient registry unlock the secrets of IBD?
- Can we predict how kids with IBD will respond to treatment?
- Can switching IBD meds heal the gut when symptoms are quiet?
- Can a milk sugar tame IBD symptoms?
- Could an extra flu shot shield vulnerable kids?