Real-World study checks if tofacitinib tames ulcerative colitis

NCT ID NCT04424303

Completed Disease control Sponsor: Pfizer Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study followed 152 adults with moderate to severe ulcerative colitis who were prescribed tofacitinib by their doctors in France. Researchers tracked how many patients felt better after one and two years of treatment, using symptom scores and noting if they needed other medications or surgery. The goal was to see how well the drug works outside of clinical trials, in everyday medical practice.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Tofacitinib (a pill that calms the immune system)

What this could lead to

If results are positive, it could confirm that tofacitinib is a useful option for controlling ulcerative colitis in real-world settings.

What could go wrong

This is an observational study, not a controlled trial, so results may be less reliable. It also does not test a new treatment, just how well an existing one works outside of strict research conditions.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

ulcerative colitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ULCERATIVE COLITIS

Contacts and locations

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Locations

Aphp - Hopital Beaujon

Clichy, 92118, France
Aphp - Hopital Saint Louis

Paris, 75466, France
CH Le Mans

Le Mans, 72037, France
CHU LYON

Pierre-Bénite, 69495, France
Centre Hospitalier de Cahors

Cahors, 46005, France
Ch Annecy Genevois

Pringy, 74374, France
Ch Bicetre

Le Kremlin-Bicêtre, 94275, France
Ch Dunkerque

Dunkirk, 59385, France
Ch Emile Roux

Le Puy-en-Velay, 43012, France
Ch Intercommunal de Creteil

Créteil, 94010, France
Ch Montfermeil

Montfermeil, 93370, France
Ch Saint Joseph Saint Luc

Lyon, 69365, France
Ch Valence

Valence, 26953, France
Ch Valenciennes

Valenciennes, 59322, France
Chu Bichat Claude Bernard

Paris, 75877, France
Chu Nantes

Nantes, 44004, France
Chu Rennes

Rennes, 35033, France
Chu de Bordeaux - Hopital Haut Leveque

Pessac, 33600, France
Clinique Beau Soleil

Montpellier, 34070, France
Clinique Jules Verne

Nantes, 44014, France
Clinique Pasteur

Toulouse, 31076, France
Clinique de l Europe

Amiens, 80090, France
Groupe Hospitalier Mutualiste Les Portes du Sud

Vénissieux, 69694, France
Groupe Hospitalier Saint Joseph

Paris, 75674, France
Hopital Albert Michallon

La Tronche, 38700, France
Hopital Caremeau

Nîmes, 30029, France
Hopital Claude Huriez

Lille, 59037, France
Hopital D'Estaing

Clermont-Ferrand, 63100, France
Hopital Europeen Georges Pompidou

Paris, 75015, France
Hopital Jean Minjoz

Besançon, 25003, France
Hopital Nord

Saint-Priest-en-Jarez, 42277, France
Hopital Rangueil

Toulouse, 31403, France
Hopital Saint Eloi

Montpellier, 34295, France
Hopital Sud

Amiens, 80480, France
Hopital Trousseau

Chambray-lès-Tours, 37171, France
Hopital de L'Archet

Nice, 06202, France
Hopital de La Cote de Nacre

Caen, 14027, France
Infirmerie Protestante de Lyon

Caluire-et-Cuire, 69300, France