Real-World study checks if tofacitinib tames ulcerative colitis
NCT ID NCT04424303
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study followed 152 adults with moderate to severe ulcerative colitis who were prescribed tofacitinib by their doctors in France. Researchers tracked how many patients felt better after one and two years of treatment, using symptom scores and noting if they needed other medications or surgery. The goal was to see how well the drug works outside of clinical trials, in everyday medical practice.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Tofacitinib (a pill that calms the immune system)
- What this could lead to
- If results are positive, it could confirm that tofacitinib is a useful option for controlling ulcerative colitis in real-world settings.
- What could go wrong
- This is an observational study, not a controlled trial, so results may be less reliable. It also does not test a new treatment, just how well an existing one works outside of strict research conditions.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Aphp - Hopital Beaujon
Clichy, 92118, France
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Aphp - Hopital Saint Louis
Paris, 75466, France
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CH Le Mans
Le Mans, 72037, France
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CHU LYON
Pierre-Bénite, 69495, France
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Centre Hospitalier de Cahors
Cahors, 46005, France
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Ch Annecy Genevois
Pringy, 74374, France
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Ch Bicetre
Le Kremlin-Bicêtre, 94275, France
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Ch Dunkerque
Dunkirk, 59385, France
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Ch Emile Roux
Le Puy-en-Velay, 43012, France
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Ch Intercommunal de Creteil
Créteil, 94010, France
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Ch Montfermeil
Montfermeil, 93370, France
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Ch Saint Joseph Saint Luc
Lyon, 69365, France
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Ch Valence
Valence, 26953, France
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Ch Valenciennes
Valenciennes, 59322, France
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Chu Bichat Claude Bernard
Paris, 75877, France
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Chu Nantes
Nantes, 44004, France
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Chu Rennes
Rennes, 35033, France
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Chu de Bordeaux - Hopital Haut Leveque
Pessac, 33600, France
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Clinique Beau Soleil
Montpellier, 34070, France
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Clinique Jules Verne
Nantes, 44014, France
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Clinique Pasteur
Toulouse, 31076, France
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Clinique de l Europe
Amiens, 80090, France
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Groupe Hospitalier Mutualiste Les Portes du Sud
Vénissieux, 69694, France
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Groupe Hospitalier Saint Joseph
Paris, 75674, France
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Hopital Albert Michallon
La Tronche, 38700, France
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Hopital Caremeau
Nîmes, 30029, France
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Hopital Claude Huriez
Lille, 59037, France
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Hopital D'Estaing
Clermont-Ferrand, 63100, France
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Hopital Europeen Georges Pompidou
Paris, 75015, France
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Hopital Jean Minjoz
Besançon, 25003, France
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Hopital Nord
Saint-Priest-en-Jarez, 42277, France
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Hopital Rangueil
Toulouse, 31403, France
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Hopital Saint Eloi
Montpellier, 34295, France
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Hopital Sud
Amiens, 80480, France
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Hopital Trousseau
Chambray-lès-Tours, 37171, France
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Hopital de L'Archet
Nice, 06202, France
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Hopital de La Cote de Nacre
Caen, 14027, France
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Infirmerie Protestante de Lyon
Caluire-et-Cuire, 69300, France
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