Humira shows promise for Long-Term control of Kids' colitis

NCT ID NCT02632175

Completed Disease control Sponsor: AbbVie Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at the long-term safety and effectiveness of adalimumab (Humira) in 59 children with ulcerative colitis who had already completed a previous trial. The children received injections every other week or weekly. Researchers tracked side effects and how well the drug controlled disease symptoms using standard scoring tools. The goal was to see if adalimumab remains safe and effective over an extended period.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: adalimumab (Humira)
What this could lead to: If successful, this could confirm that adalimumab is a safe long-term option to control ulcerative colitis in children, reducing flare-ups and improving daily life.
What could go wrong: This is a small, open-label study (no placebo) with only 59 children, so results may not apply to all patients. Long-term use of adalimumab carries risks like serious infections and allergic reactions.

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Conditions

The condition(s) this trial relates to.

ulcerative colitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ULCERATIVE COLITIS

Contacts and locations

Locations

Arnold Palmer Hospital /ID# 147295

Orlando, Florida, 32806, United States
Centrum Zdrowia MDM /ID# 147280

Warsaw, Masovian Voivodeship, 00-189, Poland
Disc_Barts Health NHS Trust - The Royal London Hospital /ID# 147290

London, Greater London, E1 2ES, United Kingdom
Duplicate_The Royal Free London NHS Foundation Trust /ID# 147292

London, Greater London, NW3 2QG, United Kingdom
Gabinet Lekarski Bartosz Korcz /ID# 147281

Rzeszów, Podkarpackie Voivodeship, 35-210, Poland
Hospital Universitario Vall d'Hebron /ID# 147288

Barcelona, 08035, Spain
Instytut Centrum Zdrowia Matki Polki /ID# 169017

Lodz, Łódź Voivodeship, 93-338, Poland
Juntendo University Hospital /ID# 147315

Bunkyo-ku, Tokyo, 113-8431, Japan
Kurume University Hospital /ID# 145710

Kurume-shi, Fukuoka, 830-0011, Japan
MNGI Digestive Health, P. A. /ID# 147294

Minneapolis, Minnesota, 55413-2195, United States
Mayo Clinic - Rochester /ID# 147304

Rochester, Minnesota, 55905-0001, United States
MultiCare Institute Health System /ID# 169005

Tacoma, Washington, 98405, United States
National Center for Child Health and Development /ID# 147312

Setagaya-ku, Tokyo, 157-8535, Japan
Univerzitna nemocnica Martin /ID# 147283

Martin, Žilina Region, 036 01, Slovakia
Uniwersytecki Szpital Dzieciecy w Krakowie /ID# 147279

Krakow, Lesser Poland Voivodeship, 30-663, Poland
Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego /ID# 147310

Wroclaw, Lower Silesian Voivodeship, 50-369, Poland

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