New study checks if filgotinib keeps ulcerative colitis in check Long-Term

NCT ID NCT05817942

Ongoing Disease control Sponsor: Alfasigma S.p.A. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study follows 509 adults with moderate to severe ulcerative colitis who are starting filgotinib, a drug also known as Jyseleca. Researchers want to see how long people stay on the treatment, how well it controls symptoms, and how it affects quality of life in everyday medical practice. The study is observational, meaning it watches what happens without changing how doctors prescribe the drug.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Filgotinib (Jyseleca)
What this could lead to: If successful, this study could confirm that filgotinib is an effective long-term treatment option for managing ulcerative colitis symptoms and improving quality of life.
What could go wrong: This is an observational study, not a controlled trial, so results may be less definitive. It also only includes people already starting filgotinib, which may limit how well findings apply to others.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

ulcerative colitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ULCERATIVE COLITIS

Contacts and locations

Locations

AKH - Medizinische Universität Wien

Vienna, 1090, Austria
ASST Fatebenefratelli Sacco

Milan, 20157, Italy
AZ Damiaan

Ostend, 8400, Belgium
AZ Maria Middelares

Ghent, 9000, Belgium
AZ Sint-Lucas

Ghent, 9000, Belgium
Akershus Universitetssykehus

Lørenskog, 1478, Norway
Amsterdam UMC (AMC)

Amsterdam, 1105 AZ, Netherlands
Azienda Ospedaliera Ospedali Riuniti Villa Sofia - Cervello

Palermo, 90146, Italy
Azienda Ospedaliera Saverio De Bellis - Castellana Grotte

Bari, Italia, 70013, Italy
Azienda Ospedaliero Universitaria Pisana - Cisanello

Pisa, Italia, 56124, Italy
Beaumont Hospital

Dublin, D09 A0HK, Ireland
Bury Care Organisation

Bury, BL97TD, United Kingdom
Bærum Hospital , Gjettum

Oslo, 1346, Norway
CHRU de Nancy

Nancy, 54000, France
CHU Amiens - Hopital Sud

Amiens, 80000, France
CHU Bordeaux - Hôpital Haut-Lévêque

Pessac, 33604, France
CHU Lille - Hôpital Claude Huriez

Lille, 59000, France
CHU Montpellier- Hôpital Saint Eloi

Montpellier, 34090, France
CHU Nantes - Hôtel Dieu

Nantes, 44093, France
CHU Saint Etienne - Hôpital Nord

Saint-Etienne, 42055, France
CHU Saint-Pierre

Brussels, 1000, Belgium
CHU de Grenoble - Hôpital Nord

Grenoble, 38043, France
CHU de Liège

Liège, 4000, Belgium
Centre Hospitalier Lyon Sud

Pierre-Bénite, 69495, France
Clinique Abroise Paré

Clichy, 92200, France
Clinique CHC MontLégia

Liège, 4000, Belgium
Cliniques Universitaires de Bruxelles Hopital Erasme

Brussels, 1070, Belgium
Cork University Hospital

Cork, T12 DFK4, Ireland
ETZ Elisabeth

Tilburg, 5022 GC, Netherlands
Erasmus MC

Rotterdam, 3015 GD, Netherlands
Fachinternistische Schwerpunktpraxis

Hamburg, 22041, Germany
Fondazione IRCCS CA' Granda Ospedale Maggiore Policlinico

Milan, 20122, Italy
Franciscus Gasthuis

Rotterdam, 3045 PM, Netherlands
Gastro Campus Research GbR

Münster, 48159, Germany
Glasgow Royal Infirmary

Glasgow, G40SF, United Kingdom
Hospital Clinic de Barcelona, C/ Villarroel, 170

Barcelona, Spain, 08036, Spain
Hospital Universitari Germans Trias i Pujol

Badalona, Spain, 08916, Spain
Hospital Universitari Son Espases

Palma de Mallorca, Spain, 07120, Spain
Hospital Universitario de Gran Canaria Dr. Negrin

Las Palmas de Gran Canaria, Spain, 35012, Spain
Hospital Universitario de Santiago de Compostela

Santiago de Compostela, Spain, 15706, Spain
Hospital de la Santa Creu i Sant Pau

Barcelona, Catalonia, 08025, Spain
Hôpital Jean Minjoz

Besançon, 25000, France
Hôpital Rangueil

Toulouse, 31059, France
Hôpital Saint-Louis

Paris, 75010, France
IRCCS Istituto Clinico Humanitas

Rozzano, 20089, Italy
IRCCS Ospedale Sacro Cuore Don Calabria

Negrar, 37024, Italy
IRCCS Ospedale San Raffaele ,Via Olgettina 60

Milan, Italia, 20132, Italy
Imeldaziekenhuis

Bonheiden, 2820, Belgium
John Radcliffe Hospital

Oxford, OX39DU, United Kingdom
KH der Barmherzigen Brüder St.Veit an der Glan

Sankt Veit an der Glan, 9300, Austria
Klinikum Klagenfurt am Wörthersee

Klagenfurt, 9020, Austria
Klinikum St. Marien Amberg

Amberg, 92224, Germany
LKH - Universitätsklinikum Graz

Graz, 8036, Austria
Magen-Darm-Zentrum Remscheid

Remscheid, 42859, Germany
Medizinisches Versorgungszentrum Dachau

Dachau, 85221, Germany
Nordlandsykehuset

Bodø, 8092, Norway
Norfolk and Norwich University Hospital

Norwich, NR47UY, United Kingdom
Onze Lieve Vrouwe Gasthuis

Amsterdam, 1091 AC, Netherlands
Oslo University Hospital

Oslo, 0424, Norway
Ospedale Mauriziano Umberto I

Torino, 10128, Italy
Praxis fur Gastroenterologie

Heidelberg, 69115, Germany
Queen Elizabeth University Hospital

Glasgow, G514TF, United Kingdom
Radboud UMC

Nijmegen, 6525 GA, Netherlands
Royal Devon University Healthcare NHS Foundation trust

Exeter, EX2 5DW, United Kingdom
Sint-Franciscus ziekenhuis

Heusden-Zolder, 3550, Belgium
Southampton General Hospital

Southampton, SO16 6YD, United Kingdom
St George's Hospital

London, SW170QT, United Kingdom
St Mark's Hospital, Central Middlesex, Acton Lane

London, NW10 7NS, United Kingdom
St Vincent's University Hospital

Dublin, D04 T6F4, Ireland
St. Olav's University Hospital

Trondheim, 7030, Norway
Synesis GmbH

Grünwald, Bavaria, 82031, Germany
The Ulster Hospital

Belfast, BT161RH, United Kingdom
UMC Utrecht

Utrecht, 3584 CX, Netherlands
UZ Leuven

Leuven, 3000, Belgium
UZA

Edegem, 2650, Belgium
Universitaetsklinikum Schleswig-Holstein

Kiel, 24105, Germany
Universitair Ziekenhuis Gent

Ghent, 9000, Belgium
Universitetssykehuset Nord-Norge

Tromsø, 9019, Norway
Universitätsklinikum Leipzig AöR

Leipzig, 04103, Germany
Universitätsklinikum Tübingen

Tübingen, 72076, Germany
Zuyderland Medisch Centrum - Sittard-Geleen

Geleen, 6162 BG, Netherlands

More trials for these conditions

Other studies related to the condition(s) this trial covers.