Could a probiotic tame ulcerative colitis? early trial begins
NCT ID NCT05666960
First seen Feb 01, 2026 · Last updated Jun 22, 2026 · Updated 22 times
Summary
This early-stage study is testing whether an oral probiotic called R-3750 is safe and tolerable for people with mild to moderate ulcerative colitis. About 36 adults will take the probiotic and be monitored for side effects, inflammation, and symptom changes. The goal is to see if this gentle approach could help control the disease.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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AP Medical Research LLC
RECRUITINGMiami, Florida, 33165, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Adtremed Research Clinic
RECRUITINGTampa, Florida, 33634, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Amicis Research Center
RECRUITINGValencia, California, 91355, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Edward Jenner Research Group, LLC
RECRUITINGPlantation, Florida, 33317, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Mayo Clinic
RECRUITINGRochester, Minnesota, 55902, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
R-3750 (probiotic)
What this could lead to
If it works, this could point toward a new, gentle treatment option for mild to moderate ulcerative colitis that uses a probiotic instead of stronger drugs.
What could go wrong
This is a very early Phase 1 trial with only 36 people, so it is primarily checking safety, not effectiveness. The probiotic may not improve symptoms or could cause side effects.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.