Could a probiotic tame ulcerative colitis? early trial begins

NCT ID NCT05666960

Recruiting now Disease control Sponsor: Rise Therapeutics LLC Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-stage study is testing whether an oral probiotic called R-3750 is safe and tolerable for people with mild to moderate ulcerative colitis. About 36 adults will take the probiotic and be monitored for side effects, inflammation, and symptom changes. The goal is to see if this gentle approach could help control the disease.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: R-3750 (probiotic)
What this could lead to: If it works, this could point toward a new, gentle treatment option for mild to moderate ulcerative colitis that uses a probiotic instead of stronger drugs.
What could go wrong: This is a very early Phase 1 trial with only 36 people, so it is primarily checking safety, not effectiveness. The probiotic may not improve symptoms or could cause side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

colitis ulcerative colitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ULCERATIVE COLITIS ULCERATIVE COLITIS CHRONIC ULCERATIVE COLITIS CHRONIC MILD ULCERATIVE COLITIS CHRONIC MODERATE

Contacts and locations

Locations

AP Medical Research LLC
RECRUITING

Miami, Florida, 33165, United States
Adtremed Research Clinic
RECRUITING

Tampa, Florida, 33634, United States
Amicis Research Center
RECRUITING

Valencia, California, 91355, United States
Edward Jenner Research Group, LLC
RECRUITING

Plantation, Florida, 33317, United States
Mayo Clinic
RECRUITING

Rochester, Minnesota, 55902, United States

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