Can a probiotic enema heal the gut lining in ulcerative colitis?

NCT ID NCT07724990

Recruiting now Disease control Sponsor: Catholic University of the Sacred Heart Source: ClinicalTrials.gov ↗

First seen Jul 24, 2026 · Last updated Jul 24, 2026

Summary

This pilot study tests whether a specific probiotic, given as a rectal enema, can improve gut health in people with mild-to-moderate ulcerative colitis. Researchers will measure changes in the gut microbiome and signs of rectal healing. The trial enrolls 20 adults aged 18 to 80 with a confirmed diagnosis of ulcerative colitis.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: a specific probiotic given as a rectal enema
What this could lead to: If it works, this could offer a new, targeted way to manage ulcerative colitis by restoring healthy gut bacteria.
What could go wrong: This is a very early, small pilot study with only 20 participants and no comparison group, so results may not be generalizable. The probiotic is experimental and its safety and effectiveness are not yet established.

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Conditions

The condition(s) this trial relates to.

Crohn disease ulcerative colitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CROHN DISEASE ULCERATIVE COLITIS

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Fondazione Policlinico Universitario Agostino Gemelli, IRCCS
RECRUITING

Roma, RM, 00146, Italy

Contact Phone: •••-•••-•••• Email: •••••@•••••

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