New oral pill H021 aims to tame Crohn's Flare-Ups
NCT ID NCT07677514
First seen Jun 30, 2026 · Last updated Jul 01, 2026 · Updated 1 time
Summary
This phase 2 trial tests whether an experimental oral tablet called H021 can help people with moderate to severe Crohn's disease. Participants receive either a low or high dose of H021 or a placebo for 12 weeks, with an option to continue treatment. The study measures symptom improvement and healing of the gut lining using endoscopy.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- H021
- What this could lead to
- If successful, H021 could offer a new oral treatment option for people with moderate to severe Crohn's disease, potentially reducing symptoms and intestinal inflammation.
- What could go wrong
- This is an early phase 2 trial with a small number of participants. The drug may not prove more effective than placebo, and side effects are still being evaluated.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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AdventHealth Medical Group Inflammatory Bowel Disease Clinic at Orlando
Orlando, Florida, 32804, United States
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Alliance Medical Research - Lighthouse Point
Lighthouse PT, Florida, 33064, United States
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Anhui Provincial Hospital
Hefei, China
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Chongqing General Hospital
Chongqing, China
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Huizhou Central People's Hospital
Huizhou, China
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Huizhou First People's Hospital
Huizhou, China
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Jiujiang First People's Hospital
Jiujiang, China
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Medical Research Center of Connecticut
Hamden, Connecticut, 06514, United States
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Peking University First Hospital
Beijing, China
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Shengjing Hospital of China Medical University
Shenyang, China
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Shenzhen Longhua District People's Hospital
Shenzhen, China
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Taihe Hospital
Shiyan, China
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The Central Hospital of Wuhan
Wuhan, China
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The First Affiliated Hospital of Bengbu Medical University
Bengbu, China
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The First Affiliated Hospital of Fujian Medical University
Fujian, China
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The First Affiliated Hospital of Sun Yat-sen University
Guangzhou, China
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The First Hospital of Quanzhou, Fujian Medical University
Fujian, China
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The Second Affiliated Hospital of Zhengzhou University
Zhengzhou, China
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The Second Xiangya Hospital of Central South University
Changsha, China
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Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Wuhan, China
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Xiangya Hospital of Central South University
Changsha, China
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Yuebei People's Hospital
Shaoguan, China
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Zhujiang Hospital of Southern Medical University
Guangzhou, China
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Zhuzhou Central Hospital
Zhuzhou, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- AI reads scans to forecast Crohn's complications
- Can stem cell vesicles heal Crohn's fistulas?
- Can a new drug calm the Gut's overactive immune response in Crohn's?
- Can a new drug keep Crohn's disease in check?
- Can a biologic drug tame Crohn's without steroids? a large Real-World study investigates
- Can a glass of pomegranate juice tame gut inflammation?