Placenta cells could tame Crohn's inflammation

NCT ID NCT01155362

Completed Disease control Sponsor: Celularity Incorporated Source: ClinicalTrials.gov ↗

First seen Jul 07, 2026 · Last updated Jul 08, 2026 · Updated 1 time

Summary

This trial investigates whether intravenous infusions of cells from the human placenta (PDA001) can reduce inflammation and improve symptoms in adults with moderate-to-severe Crohn's disease. Participants receive either one of three doses of PDA001 or a placebo, and researchers track safety and effectiveness over time. The goal is to see if this cell-based approach offers a new way to control this chronic digestive condition.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: human placenta-derived cells (PDA001)
What this could lead to: If successful, this could point toward a new treatment option for people with moderate-to-severe Crohn's disease.
What could go wrong: This is an early Phase 2a study with only 50 participants, so results may not apply to everyone. The treatment may not work better than placebo, and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Crohn disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CROHN'S DISEASE

Contacts and locations

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Locations

Baylor College of Medicine

Houston, Texas, 77030, United States
Case Western Reserve University

Cleveland, Ohio, 44106-5066, United States
Cedars Sinai Medical Center

Los Angeles, California, 90048, United States
Indiana University

Indianapolis, Indiana, 46202-5149, United States
McGuire VA Medical Center

Richmond, Virginia, 23249, United States
Mt Sinai Hospital

New York, New York, 10029, United States
Rochester General Hospital

Rochester, New York, 14621, United States
Stony Brook University

Stony Brook, New York, 11794-8173, United States
University of California, Irvine

Orange, California, 92868, United States
University of Chicago Medical Center

Chicago, Illinois, 60637, United States
University of Florida

Gainesville, Florida, 32610, United States
Vanderbilt University

Nashville, Tennessee, 37212, United States
Yale School of Medicine Digestive Diseases

New Haven, Connecticut, 06510, United States

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