New pill aims to tame Crohn's Flare-Ups

NCT ID NCT06226883

Recruiting now Disease control Sponsor: Morphic Therapeutic, Inc. (A Wholly Owned Subsidiary of Eli Lilly and Company) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 21, 2026 · Updated 4 times

Summary

This study tests an experimental pill called MORF-057 (zotemtegrast) in 385 adults with moderate-to-severe Crohn's disease. The drug works by blocking a protein that drives gut inflammation. Participants will receive one of three doses of the drug or a placebo for 14 weeks to see if it reduces intestinal damage and improves symptoms.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: MORF-057 (zotemtegrast), an oral pill that blocks a protein involved in gut inflammation
What this could lead to: If successful, this could provide a new oral treatment option for people with Crohn's disease who haven't responded to other therapies.
What could go wrong: This is an early Phase 2 trial with a moderate number of participants. The drug may not work better than placebo, and side effects are still being studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Crohn disease inflammatory bowel disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CROHN'S DISEASE INFLAMMATORY BOWEL DISEASES

Contacts and locations

Locations

"Gastromed" Medical Center
RECRUITING

Shymkent, 160005, Kazakhstan
"Landa" Specialist Doctor's Offices
RECRUITING

Krakow, 31-156, Poland
"MEDIS" Medical Center
RECRUITING

Bydgoszcz, 85-229, Poland
"Medical Center Kanev" EOOD
NOT_YET_RECRUITING

Rousse, 7002, Bulgaria
"Sfanta Treime" Municipal Clinical Hospital
NOT_YET_RECRUITING

Chisinau, MD-2068, Moldova
"Sfanta Vineri" Medical Center
RECRUITING

Bucharest, 011273, Romania
"Vita Longa" Non-Public Healthcare Facility, Limited Liability Company
RECRUITING

Katowice, 40-748, Poland
AES - DRS - Synexus Polska Sp. z o.o. Oddzial w Gdansku
RECRUITING

Gdansk, 80-382, Poland
Agaplesion Markus Hospital
NOT_YET_RECRUITING

Frankfurt am Main, 60431, Germany
Amrita Institute of Medical Sciences and Research Centre
RECRUITING

Kochi, 682041, India
Apollo Cancer Centre
RECRUITING

Chennai, 600035, India
Applied Neuroscience Research Institute A.C.
RECRUITING

Durango, 34000, Mexico
Asahikawa Medical College Hospital
RECRUITING

Asahikawa, 078-8510, Japan
Atlanta Gastroenterology Associates (Part of United Digestive)
NOT_YET_RECRUITING

Atlanta, Georgia, 30342, United States
Atlanta Gastroenterology Specialists, PC
RECRUITING

Atlanta, Georgia, 30024, United States
Axon Clinical, s.r.o.
RECRUITING

Prague, 14000, Czechia
Azienda Ospedaliera San Camillo Forlanini
RECRUITING

Roma, 00152, Italy
Bekes Megyei Kozponti Korhaz Dr. Rethy Pal Tagkorhaz IV. Belgyogyaszat
RECRUITING

Békéscsaba, 5600, Hungary
Big Metropolitan Hospital Niguarda Regional Health Authority
RECRUITING

Milan, 20162, Italy
Bioresearch Partner-Kendale Lakes
NOT_YET_RECRUITING

Miami, Florida, 33155, United States
Bugat Pal Hospital Gyongyos
RECRUITING

Gyöngyös, 3200, Hungary
CHRU Nancy Brabois - Hôpital d'Enfants
RECRUITING

Vandœuvre-lès-Nancy, 54500, France
CLINFAN Szolgáltató Kft
RECRUITING

Szekszárd, 7100, Hungary
CLINSANTE Clinical Research Centre Ewa Galczak-Nowak, Malgorzata Trzaska
RECRUITING

Bydgoszcz, 85-794, Poland
CaRe Clinic
NOT_YET_RECRUITING

Alberta, T4P 1K4, Canada
Cantonal Hospital Zenica, Department of Internal Medicine
NOT_YET_RECRUITING

Zenica, 72000, Bosnia and Herzegovina
Cardiomet Cequin S.A.S., Research Unit
RECRUITING

Armenia, 630004, Colombia
Cardiovascular Foundation of Colombia
RECRUITING

Floridablanca, 681017, Colombia
Care Access Research - Ogden
RECRUITING

Ogden, Utah, 84403, United States
Centro de Estudios Clínicos de Querétaro (CECLIQ)
RECRUITING

Querétaro, 76000, Mexico
Centro de Investigacion Clinica Chapultepec S.A. de C.V.
RECRUITING

Morelia, 58260, Mexico
Chang Gung Memorial Hospital - Linkou
NOT_YET_RECRUITING

Taoyuan City, 333, Taiwan
Charite - University Hospital Berlin
RECRUITING

Berlin, 10117, Germany
Chi Mei Medical Center
NOT_YET_RECRUITING

Tainan, 71004, Taiwan
China Medical University Hospital
NOT_YET_RECRUITING

Taichung, 404327, Taiwan
Chronos Pesquisa Clínica
RECRUITING

Brasília, 72145-450, Brazil
Clinical Center " Dr Dragisa Misovic Dedinje"
RECRUITING

Belgrade, 11000, Serbia
Clinical Hospital Center Bezanijska Kosa
RECRUITING

Belgrade, 11000, Serbia
Clinical Research of Osceola
RECRUITING

Kissimmee, Florida, 34741, United States
Cliniq s.r.o.
RECRUITING

Bratislava, 811 09, Slovakia
Clinique IMD
NOT_YET_RECRUITING

Montreal, H3H 1E8, Canada
Clinoxus s.r.o., Outpatient Clinic Budejovicka
RECRUITING

Prague, 140 00, Czechia
Clínica Hepatogastro JK
RECRUITING

São Paulo, 04543-011, Brazil
Colentina Clinical Hospital
RECRUITING

Bucharest, 020125, Romania
Complejo Hospitalario Universitario de Ferrol (CHUF)- Hospital Naval
RECRUITING

Ferrol, 15405, Spain
Corporation for Health Studies "CES"
RECRUITING

Medellín, 050012, Colombia
Cross Creek Medical Clinic
RECRUITING

Fayetteville, North Carolina, 28304, United States
DRK Clinic Berlin-Koepenick
RECRUITING

Berlin, 12559, Germany
Dayanand Medical College and Hospital
NOT_YET_RECRUITING

Ludhiana, 141001, India
Diagnostic Center of Shymkent
RECRUITING

Shymkent, 160021, Kazakhstan
Diagnostic Consultative Center XX - Sofia
NOT_YET_RECRUITING

Sofia, 1618, Bulgaria
Diex Recherche Quebec Inc.
RECRUITING

Québec, G1V 4T3, Canada
Ditmanson Medical Foundation Chia-Yi Christian Hospital
NOT_YET_RECRUITING

Chiayi City, 60002, Taiwan
EMC Medical Institute Joint Stock Company, "Certus" Private Healthcare Facility Hospital No. 1
RECRUITING

Poznan, 60-309, Poland
ENDOMED s.r.o.
RECRUITING

Košice, 04013, Slovakia
ETG Warszawa
NOT_YET_RECRUITING

Warsaw, 02-677, Poland
East Tallinn Central Hospital
NOT_YET_RECRUITING

Tallinn, 10138, Estonia
Emergency Cardiology Center by Academician G. Chapidze LLC
RECRUITING

Tbilisi, 0159, Georgia
Endoscopic Research Inc
NOT_YET_RECRUITING

Orlando, Florida, 32803, United States
Endoskopia Sp. z.o.o.
RECRUITING

Sopot, 81-756, Poland
Faculdade de Medicina da UNESP
NOT_YET_RECRUITING

Botucatu, 18618-687, Brazil
Far Eastern Memorial Hospital
NOT_YET_RECRUITING

New Taipei City, 22060, Taiwan
Fejer County St. Gyorgy University Teaching Hospital
RECRUITING

Székesfehérvár, H-8000, Hungary
Fukuoka University Chikushi Hospital
RECRUITING

Chikushino-shi, 818-8502, Japan
Fundación Valle del Lili
RECRUITING

Cali, 760032, Colombia
GASTRO I., s.r.o.
RECRUITING

Prešov, 08001, Slovakia
GI Alliance - Cedar Park
RECRUITING

Cedar Park, Texas, 78613, United States
GLOBE Clinical Research Sp. z o.o.
NOT_YET_RECRUITING

Kłodzko, 57-300, Poland
Gastro Care Institute
RECRUITING

Lancaster, California, 93534, United States
Gastro LM s.r.o.
RECRUITING

Prešov, 08001, Slovakia
GastroPraxis Magdeburg
NOT_YET_RECRUITING

Magdeburg, 110 39104, Germany
Gastroenterology Associates of Central Virginia
RECRUITING

Lynchburg, Virginia, 24502, United States
Gastrointestinal Associates of Northeast Tennessee
RECRUITING

Johnson City, Tennessee, 44060, United States
General Hospital "Djordje Joanovic"
RECRUITING

Zrenjanin, 23000, Serbia
General Hospital Leskovac
RECRUITING

Leskovac, 16000, Serbia
General Hospital Uzice
RECRUITING

Užice, 31000, Serbia
Group Practice Jakobeit
RECRUITING

Wipperfürth, 51688, Germany
H-T. Medical Center
RECRUITING

Tychy, 43-100, Poland
High Technology Hospital Medcenter LLC
RECRUITING

Batumi, 6010, Georgia
Hospices Civils de Lyon - Lyon Sud
RECRUITING

Pierre-Bénite, 69310, France
Hospital Ludwig-Maximilians-University Munich, Campus Grosshadern
NOT_YET_RECRUITING

Munich, 81377, Germany
Hospital Pablo Tobon Uribe
RECRUITING

Medellín, 050034, Colombia
Hospital Plava Medical Group
NOT_YET_RECRUITING

Tuzla, 75000, Bosnia and Herzegovina
Hospital Universitario Arnau de Vilanova de Lleida
RECRUITING

Lleida, 25198, Spain
Hospital Universitario La Paz
RECRUITING

Madrid, 28046, Spain
Hospital Universitario Puerta de Hierro Majadahonda
RECRUITING

Majadahonda, 28222, Spain
Hospital Universitario Virgen Macarena
RECRUITING

Seville, 41009, Spain
Hospital of Padova
NOT_YET_RECRUITING

Padova, 35128, Italy
IBD SA SA Group of Specialists
NOT_YET_RECRUITING

Kurralta Park, 5037, Australia
IRCCS Istituto Clinico Humanitas- Centro Malattie Infiammatorie Intestinali
RECRUITING

Rozzano, 20089, Italy
IRCCS Ospedale Casa Sollievo della Sofferenza
RECRUITING

San Giovanni Rotondo, 71013, Italy
IRCCS Policlinico San Donato
RECRUITING

San Donato Milanese, 20097, Italy
IRCCS San Raffaele
RECRUITING

Milan, 20132, Italy
Infinity Clinical Research
NOT_YET_RECRUITING

San Diego, California, 92108, United States
Institute of Medical Sciences & SUM Hospital, Siksha 'O' Anusandhan, Department of Gastroenterology & Hepatology
NOT_YET_RECRUITING

Bhubaneswar, 751003, India
Institute of Science Tokyo Hospital
RECRUITING

Bunkyō, 113-8519, Japan
Integrated University Health and Social Services Center of Saguenay-Lac-Saint-Jean
NOT_YET_RECRUITING

Chicoutimi, G7H 5H6, Canada
Kaohsiung Medical University Chung-Ho Memorial Hospital
NOT_YET_RECRUITING

Kaohsiung City, 807377, Taiwan
Kaohsiung Veterans General Hospital
NOT_YET_RECRUITING

Kaohsiung City, 81362, Taiwan
Karaganda Medical University
RECRUITING

Karaganda, 100000, Kazakhstan
Key Stone Clinical Trials
RECRUITING

Mexico City, Distrito Federal, 06100, Mexico
Kobe University Hospital
RECRUITING

Kobe, 650-0017, Japan
Kokikai Tsujinaka Hospital Kashiwanoha
RECRUITING

Kashiwa-shi, 277-0871, Japan
LEPL The First University Clinic of Tbilisi State Medical University
RECRUITING

Tbilisi, 0178, Georgia
LTD Aversi Clinic
RECRUITING

Tbilisi, 0160, Georgia
LTD Institute of Clinical Cardiology
RECRUITING

Tbilisi, 0159, Georgia
LTD The First Medical Center
RECRUITING

Tbilisi, 0180, Georgia
Las Vegas Clinical Trials
NOT_YET_RECRUITING

North Las Vegas, Nevada, 89030, United States
Liepaja Regional Hospital
RECRUITING

Liepāja, LV-3414, Latvia
Lisie Hospital
RECRUITING

Kochi, 682017, India
Loema Clinical Research Institute and Consultants SS Ltda- i9 Clinical Research
NOT_YET_RECRUITING

Campinas, 13093-133, Brazil
London Digestive Disease Institute
NOT_YET_RECRUITING

London, N6K 1M6, Canada
London Health Sciences Centre
RECRUITING

London, N6A 4L6, Canada
MDM Healthcare Centre
COMPLETED

Warsaw, 00-189, Poland
Mackay Memorial Hospital
NOT_YET_RECRUITING

Taipei, 10449, Taiwan
Markhot Ferenc Oktatókórház
RECRUITING

Eger, 3300, Hungary
Max Super Speciality Hospital
RECRUITING

New Delhi, 110 017, India
Medical Care Unit Dachau
RECRUITING

Dachau, 85221, Germany
Medical Care and Research SA de CV
RECRUITING

Mérida, 97070, Mexico
Medical Centre Oporow
RECRUITING

Wroclaw, 52-416, Poland
Medical Clinical Surgical Center Specialized in Research
RECRUITING

Jalisco, 45640, Mexico
Medical University Hematology
RECRUITING

Innsbruck, 6020, Austria
Medical University of Vienna
RECRUITING

Vienna, 1090, Austria
Military Hospital Brno,
RECRUITING

Brno, 615 00, Czechia
Monza Oncology Hospital SRL
RECRUITING

Bucharest, 013823, Romania
Mount Sinai Hospital
RECRUITING

Toronto, M5G 1X5, Canada
Nagasaki University Hospital
RECRUITING

Nagasaki, 852-8501, Japan
Nara Prefecture General Medical Center
RECRUITING

Nara, 630-8054, Japan
National Research Medical Center
RECRUITING

Astana, Z00P6K6, Kazakhstan
National Taiwan University Hospital
NOT_YET_RECRUITING

Hsinchu, 302, Taiwan
National Taiwan University Hospital
NOT_YET_RECRUITING

Taipei, 100225, Taiwan
Navneet Memorial Hospital SUSHRUSHA
RECRUITING

Ahmedabad, 380009, India
NewData FBHC, NewData Clinical Research
NOT_YET_RECRUITING

Aracaju, 49075-000, Brazil
Noble Hospital Pvt Ltd
RECRUITING

Pune, 411013, India
Non-public Health Care Center KERmed Medical Centre
RECRUITING

Bydgoszcz, 85-231, Poland
North Texas Gastroenterology
NOT_YET_RECRUITING

Denton, Texas, 76210, United States
Northern University Foundation Hospital
RECRUITING

Soledad, 083001, Colombia
Nova Scotia Health Authority
RECRUITING

Halifax, B3H 1V7, Canada
Oaxaca Site Management Organization
RECRUITING

Oaxaca City, 68000, Mexico
Oncohelp Association
RECRUITING

Timișoara, 300239, Romania
Osaka Metropolitan University Hospital
RECRUITING

Osaka, 5450051, Japan
Oslomed Medical Center
NOT_YET_RECRUITING

Krakow, 31-228, Poland
Ospedale Sacro Cuore Don G. Calabria
RECRUITING

Negrar, 37024, Italy
PLEJADY Medical Centre
RECRUITING

Krakow, 30-363, Poland
PMSI "Timofei Mosneaga" Republican Clinical Hospital, Outpatient Department
NOT_YET_RECRUITING

Chisinau, MD-2025, Moldova
PMSI "Timofei Mosneaga" Republican Clinical Hospital, Therapy Department, Division of Gastroenterology
NOT_YET_RECRUITING

Chisinau, MD-2025, Moldova
Palmetto Gastroenterology Clinical Research
RECRUITING

Summerville, South Carolina, 29486, United States
Pauls Stradins Clinical Univeristy Hospital
RECRUITING

Riga, LV-1002, Latvia
Peak Gastroenterology Associates - Colorado Springs
RECRUITING

Colorado Springs, Colorado, 80921, United States
Pesquisare
RECRUITING

Santo André, 09080-110, Brazil
Peters Medical Research
NOT_YET_RECRUITING

High Point, North Carolina, 27260, United States
Poliambulanza Hospital
NOT_YET_RECRUITING

Brescia, 25124, Italy
Policlinico S. Orsola-Malpighi
RECRUITING

Bologna, 40138, Italy
Poliklinika Borzan
RECRUITING

Osijek, 31000, Croatia
Poliklinika Solmed
RECRUITING

Zagreb, 10000, Croatia
Prairie Institute of Liver and Luminal Advanced Research
NOT_YET_RECRUITING

Lethbridge, T1J 4G9, Canada
Prime Clinical Research
NOT_YET_RECRUITING

Mansfield, Texas, 76063, United States
Prime Clinical Research - Lewisville
NOT_YET_RECRUITING

Lewisville, Texas, 75067, United States
Prime Institute of Digestive Sciences
RECRUITING

Rajkot, 360001, India
Princess Alexandra Hospital, Metro South Health
NOT_YET_RECRUITING

Woolloongabba, QLD, 4102, Australia
Proactive CR México SA de CV
RECRUITING

Irapuato, 36520, Mexico
Royal Brisbane and Women's Hospital
NOT_YET_RECRUITING

Herston, 4029, Australia
Royal Perth Hospital
NOT_YET_RECRUITING

Perth, 6000, Australia
Rtl Sm Srl
NOT_YET_RECRUITING

Chisinau, MD2072, Moldova
S R Kalla Memorial Gastro and General Hospital
RECRUITING

Jaipur, 302006, India
SIDS Hospital and Research Centre
RECRUITING

Surat, 395002, India
SMS Medical College Hospital
RECRUITING

Jaipur, 302004, India
SSM Health DePaul Hospital- St. Louis
NOT_YET_RECRUITING

Bridgeton, Missouri, 063044, United States
Saga University Hospital
RECRUITING

Saga, 849-8501, Japan
Saitama Medical Center
RECRUITING

Saitama-Ken, 350 8550, Japan
Salzburg Regional Hospital
RECRUITING

Salzburg, 5020, Austria
Samvedna Hospital
RECRUITING

Varanasi, 221005, India
Sana Clinic
RECRUITING

Astana, Z00P6K6, Kazakhstan
Sana Hospital Duisburg
RECRUITING

Duisburg, 53119, Germany
Sapporo Higashi Tokushukai Hospital
RECRUITING

Sapporo, 065-0033, Japan
Scarborough Center for Inflammatory Bowel Disease
RECRUITING

Scarborough, M1B 3V4, Canada
Scientific Research Institute of Cardiology and Internal Disease of the Ministry of Health of the Republic of Kazakhstan
RECRUITING

Almaty, 050000, Kazakhstan
Semey Medical University
RECRUITING

Semey, 071400, Kazakhstan
Semmelweis Medical University
RECRUITING

Budapest, 1083, Hungary
Shree Giriraj Multispeciality Hospital
RECRUITING

Rajkot, 360005, India
Sir Charles Gairdner Hospital
NOT_YET_RECRUITING

Perth, 6009, Australia
Southern Adelaide Local Health Network
NOT_YET_RECRUITING

Bedford Park, 5042, Australia
Specialty hospital Medico Rijeka
RECRUITING

Rijeka, 51000, Croatia
St Joseph'S Health Centre Toronto
RECRUITING

Toronto, M6R 1B5, Canada
St. John Paul 2nd Municipal Hospital in Elblag
COMPLETED

Elblag, 82-300, Poland
St. Vincent's Hospital
NOT_YET_RECRUITING

Melbourne, 3065, Australia
SurGal Clinic s.r.o.
RECRUITING

Brno, 602 00, Czechia
Synexus Polska - Katowicach
RECRUITING

Katowice, 40-040, Poland
Synexus Polska Sp. Z o.o. Branch in Czestochowa
RECRUITING

Częstochowa, 42-202, Poland
Synexus Polska Sp. z o.o.
RECRUITING

Wroclaw, 50-381, Poland
Synexus Polska Sp. z o.o. Branch in Poznan
RECRUITING

Poznan, 81-537, Poland
Synexus Polska Sp. z o.o. Oddzial w Warszawie
RECRUITING

Warsaw, 02-672, Poland
Taichung Veterans General Hospital
NOT_YET_RECRUITING

Taichung, 407219, Taiwan
Taipei Veterans General Hospital
NOT_YET_RECRUITING

Taipei, 11217, Taiwan
Tandem Clinical Research
RECRUITING

Houma, Louisiana, 70360, United States
Tartu University Hospital, Department of Gastroenterology
NOT_YET_RECRUITING

Tartu, 50406, Estonia
The Alfred Hospital
NOT_YET_RECRUITING

Melbourne, 3004, Australia
The University of Texas Health Science Center at Houston
RECRUITING

Houston, Texas, 77030, United States
Toho University Sakura Medical Center
RECRUITING

Sakura, 285-8741, Japan
Tokitokai Tokito Clinic
RECRUITING

Saitama, 336-0963, Japan
Tokyo Yamate Medical Center
RECRUITING

Tokyo, 169-0073, Japan
Toronto Digestive Disease Associates, Inc.
RECRUITING

Vaughan, L4L 4Y7, Canada
Tropical Clinical Trials
NOT_YET_RECRUITING

Palmetto Bay, Florida, 33176, United States
Twoja Przychodnia Medical Centre of Opole
RECRUITING

Opole, 45-819, Poland
Twoja Przychodnia Medical Centre of Poznan
RECRUITING

Poznan, 60-324, Poland
Twoja Przychodnia-Szczecinskie Centrum Medyczne
RECRUITING

Szczecin, 71-434, Poland
Tyler Research Institute, LLC
RECRUITING

Tyler, Texas, 75701, United States
Universita Degli Studi-Magna Graecia-de Catanzaro
NOT_YET_RECRUITING

Catanzaro, 88100, Italy
University Clinical Centre of the Republic of Srpska
NOT_YET_RECRUITING

Banja Luka, 78000, Bosnia and Herzegovina
University Hospital City of Health and Science of Turin - Hospital Molinette
NOT_YET_RECRUITING

Turin, 10126, Italy
University Hospital Halle (Saale)
RECRUITING

Halle, 06120, Germany
University Hospital Schleswig-Holstein
RECRUITING

Kiel, 24105, Germany
University Hospital St. Poelten
RECRUITING

Sankt Pölten, 3100, Austria
University and Polytechnic Hospital La Fe
RECRUITING

Valencia, 46026, Spain
University of Leipzig Medical Cent
NOT_YET_RECRUITING

Leipzig, 04103, Germany
Universitätsklinikum Heidelberg
RECRUITING

Heidelberg, 69120, Germany
VGM Hospital
NOT_YET_RECRUITING

Coimbatore, 641005, India
WIP Warsaw IBD Point Profesor Kierkus
RECRUITING

Warsaw, 04-501, Poland
WSD Medi
RECRUITING

Warsaw, 02-786, Poland
Wake Research Associates
NOT_YET_RECRUITING

Raleigh, North Carolina, 27612, United States
West Tallinn Central Hospital
NOT_YET_RECRUITING

Tallinn, 10617, Estonia
Wolfsburg Hospital Department of internal Medicine
NOT_YET_RECRUITING

Wolfsburg, 38440, Germany
Yamanashi Prefectural Central Hospital
RECRUITING

Kofu, 400-0027, Japan
Yashoda Hospital
RECRUITING

Secunderabad, 500003, India
Zvezdara University Medical Center
RECRUITING

Belgrade, 11 000, Serbia

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