New hope for Crohn's: experimental drug SAR442970 enters phase 2 trial

NCT ID NCT06958536

Recruiting now Disease control Sponsor: Sanofi Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2 trial is testing an experimental drug called SAR442970 in about 99 adults with moderate to severe Crohn's disease. Participants will receive either the drug or a placebo as a shot under the skin. The main goal is to see if the drug can improve the appearance of the gut lining during a scope exam after 16 weeks. The study lasts up to 168 weeks and includes a long-term extension where eligible participants can receive the drug openly.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: SAR442970 (an experimental drug given as a shot under the skin)
What this could lead to: If successful, this could point toward a new treatment option for people with moderate to severe Crohn's disease who haven't responded well to current therapies.
What could go wrong: This is an early phase 2 trial with only 99 participants, so results may not apply to everyone. The drug may not work better than placebo, and side effects are still being studied.

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Conditions

The condition(s) this trial relates to.

Crohn disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CROHN'S DISEASE

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Investigational Site Number 8400028
RECRUITING

Miami, Florida, 33134, United States
Investigational Site Number: 0360001
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Footscray, 3011, Australia
Investigational Site Number: 0360002
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Brisbane, Queensland, 4101, Australia
Investigational Site Number: 0360004
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Kurralta Park, South Australia, 5037, Australia
Investigational Site Number: 0560001
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Leuven, B-3000, Belgium
Investigational Site Number: 1560001
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Guangzhou, 510655, China
Investigational Site Number: 1560006
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Hangzhou, 310009, China
Investigational Site Number: 1560007
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Shenyang, 110004, China
Investigational Site Number: 1560008
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Changsha, 410013, China
Investigational Site Number: 2030002
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Brno, JM, 61500, Czechia
Investigational Site Number: 2030003
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Hradec Králové, 50012, Czechia
Investigational Site Number: 2030005
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Slaný, 274 01, Czechia
Investigational Site Number: 2500001
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Montpellier, 34090, France
Investigational Site Number: 2500002
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Toulouse, 31059, France
Investigational Site Number: 2500003
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Nice, 6000, France
Investigational Site Number: 2760001
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Ulm, 89081, Germany
Investigational Site Number: 2760002
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Minden, Northwest, 32423, Germany
Investigational Site Number: 2760003
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Jena, 07747, Germany
Investigational Site Number: 2760004
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Kiel, 24105, Germany
Investigational Site Number: 3920001
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Morioka, 020-8505, Japan
Investigational Site Number: 3920002
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Nishinomiya, 663-8501, Japan
Investigational Site Number: 3920003
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Hamamatsu, 431-3192, Japan
Investigational Site Number: 3920004
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Bunkyō City, 113-8519, Japan
Investigational Site Number: 3920005
RECRUITING

Ōita, Oita Prefecture, 870-0033, Japan
Investigational Site Number: 3920006
RECRUITING

Hamamatsu, Shizuoka, 432-8061, Japan
Investigational Site Number: 3920007
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Kashiwa, Chiba, 277-0871, Japan
Investigational Site Number: 3920009
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Hirosaki, 036-8545, Japan
Investigational Site Number: 6160001
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Krakow, 31-501, Poland
Investigational Site Number: 6160002
RECRUITING

Wroclaw, Lower Silesian Voivodeship, 53-149, Poland
Investigational Site Number: 6160003
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Warsaw, 01-783, Poland
Investigational Site Number: 6160004
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Wroclaw, 54-206, Poland
Investigational Site Number: 6160005
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Lublin, 20-582, Poland
Investigational Site Number: 6160006
RECRUITING

Sopot, 81-756, Poland
Investigational Site Number: 6160008
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Warsaw, 00-189, Poland
Investigational Site Number: 7100003
RECRUITING

Johannesburg, 1619, South Africa
Investigational Site Number: 7240001
RECRUITING

Madrid, 28046, Spain
Investigational Site Number: 7240002
RECRUITING

Madrid, 28003, Spain
Investigational Site Number: 7240003
RECRUITING

Seville, 41009, Spain
Investigational Site Number: 8260001
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London, SE1 7EH, United Kingdom
Investigational Site Number: 8260002
RECRUITING

London, HA8 0AD, United Kingdom
Investigational Site Number: 8260004
RECRUITING

Cambridge, CB2 0QQ, United Kingdom
Investigational Site Number: 8260005
RECRUITING

London, E11 1NR, United Kingdom
Investigational Site Number: 8260007
RECRUITING

Bury, BL9 7TD, United Kingdom
Investigational Site Number: 8400001
RECRUITING

Lancaster, California, 93534, United States
Investigational Site Number: 8400002
RECRUITING

Fredericksburg, Texas, 78229, United States
Investigational Site Number: 8400003
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Chapel Hill, North Carolina, 27599, United States
Investigational Site Number: 8400005
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Escondido, California, 92025, United States
Investigational Site Number: 8400006
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Kansas City, Kansas, 66160, United States
Investigational Site Number: 8400007
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Orlando, Florida, 32804, United States
Investigational Site Number: 8400008
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Wyoming, Michigan, 49519, United States
Investigational Site Number: 8400009
RECRUITING

Harrisburg, Pennsylvania, 17110, United States
Investigational Site Number: 8400011
RECRUITING

Palmetto Bay, Florida, 33176, United States
Investigational Site Number: 8400012
RECRUITING

Miami, Florida, 33136, United States
Investigational Site Number: 8400013
RECRUITING

St Louis, Missouri, 63110, United States
Investigational Site Number: 8400015
RECRUITING

Lighthouse PT, Florida, 33064, United States
Investigational Site Number: 8400016
RECRUITING

Ogden, Utah, 84405, United States
Investigational Site Number: 8400017
RECRUITING

Kissimmee, Florida, 34741, United States
Investigational Site Number: 8400019
RECRUITING

Marietta, Georgia, 30060, United States
Investigational Site Number: 8400022
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Boston, Massachusetts, 02115, United States
Investigational Site Number: 8400024
RECRUITING

Tucson, Arizona, 85724, United States
Investigational Site Number: 8400025
RECRUITING

Iowa City, Iowa, 52242, United States
Investigational Site Number: 8400027
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Richmond, Virginia, 23249, United States
Investigative Site: 1560002
RECRUITING

Shanghai, 200092, China
Investigative Site: 1560003
RECRUITING

Changsha, 410011, China
Investigative Site: 1560004
RECRUITING

Nanchang, 330006, China
Investigative Site: 1560005
RECRUITING

Changzhou, 213003, China

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