New hope for Crohn's: drug trial aims to tame gut inflammation

NCT ID NCT05837897

Recruiting now Disease control Sponsor: Takeda Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 3 trial tests the drug vedolizumab in 408 adults in China with moderate-to-severe Crohn's disease. Participants receive IV infusions of vedolizumab or a placebo over several weeks. The goal is to see if vedolizumab can reduce symptoms like abdominal pain and diarrhea, and help achieve remission.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: vedolizumab
What this could lead to: If successful, this could provide a new treatment option for people in China with moderate-to-severe Crohn's disease to control symptoms and improve quality of life.
What could go wrong: This is a late-stage trial, but results may not apply to all patients. Vedolizumab may not work for everyone and can have side effects like infections or allergic reactions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Crohn disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CROHN'S DISEASE

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Changshu No.2 People's Hospital
RECRUITING

Suzhou, Jiangsu, 215516, China
Changzhou No.2 People's Hospital - Yanling Campus
RECRUITING

Changzhou, Jiangsu, 213200, China
Guangzhou First People's Hospital
RECRUITING

Guangzhou, Guangdong, 510180, China
Huizhou Central People's Hospital
RECRUITING

Huizhou, Guangdong, 516001, China
Lanzhou University Second Hospital
RECRUITING

Lanzhou, Gansu, 730030, China
Nanyang First People's Hospital
RECRUITING

Nanyang, Henan, 474500, China
Peking University First Hospital - Changqiao Campus
COMPLETED

Beijing, Beijing Municipality, 100034, China
Peking University Third Hospital
RECRUITING

Beijing, Beijing Municipality, 100191, China
People's Hospital of Ningxia Hui Aotonomous Region
COMPLETED

Yinchuan, Ningxia, 750002, China
People's Hospital of Quzhou
COMPLETED

Quzhou, Zhejiang, 324307, China
Qingyuan People's Hospital
COMPLETED

Qingyuan, Guangdong, 511518, China
Renmin Hospital of Wuhan University - Main Campus
RECRUITING

Wuhan, Hubei, 430060, China
Shanghai Changhai Hospital
RECRUITING

Shanghai, Shanghai Municipality, 200433, China
Shanghai East Hospital - Main
RECRUITING

Shanghai, Shanghai Municipality, 200123, China
Shengjing Hospital of China Medical University - Nanhu Campus
RECRUITING

Shenyang, Liaoning, 110004, China
Taizhou Hospital of Zhejiang Province - Main
RECRUITING

Taizhou, Zhejiang, 317000, China
The 1st Affiliated Hospital of Wenzhou Medical University - Nanbaixiang Campus
COMPLETED

Wenzhou, Zhejiang, 325000, China
The 2nd Affliated Hospital of Harbin Medical University
RECRUITING

Haerbin, Heilongjiang, 150081, China
The Fifth Affiliated Hospital Sun Yat-Sen University
RECRUITING

Zhuhai, Guangdong, 519000, China
The First Affiliated Hospital of Fujian Medical University
RECRUITING

Fuzhou, Fujian, 350005, China
The First Affiliated Hospital of Ningbo University - Fangqiao Campus
RECRUITING

Ningbo, Zhejiang, 315010, China
The First Affiliated Hospital, Sun Yat-sen University - Main
RECRUITING

Guangzhou, Guangdong, 510080, China
The First Affiliated Hospital, Zhejiang University School of Medicine - Qingchun Campus - PPDS
RECRUITING

Hangzhou, Zhejiang, 310003, China
The First People's Hospital of Foshan
RECRUITING

Foshan, Guangdong, 528000, China
The First People's Hospital of Wenling
RECRUITING

Taizhou, Zhejiang, 317599, China
The First People's Hospital of Yunnan Province
RECRUITING

Kunming, Yunnan, 650100, China
The Second Affiliated Hospital of Guangzhou Medical University
RECRUITING

Guangzhou, Guangdong, 510260, China
The Second Affiliated Hospital of Nanchang University - Donghu Campus
RECRUITING

Nanchang, Jiangxi, 330008, China
The Second Hospital of Anhui Medical University
RECRUITING

Hefei, Anhui, 230601, China
The Second Hospital of Hebei Medical University - Main
COMPLETED

Shijiazhuang, Hebei, 50051, China
The Second Xiangya Hospital of Central South University
RECRUITING

Changsha, Hunan, 410011, China
The Sixth Affiliated Hospital, Sun Yat-sen University
RECRUITING

Guangzhou, Guangdong, 510655, China
The Third Affiliated Hospital, Sun Yat-Sen University
COMPLETED

Guangzhou, Guangdong, 510630, China
The University of Hong Kong - Shenzhen Hospital
RECRUITING

Shenzhen, Guangdong, 518053, China
Tianjin Medical University General Hospital
RECRUITING

Tianjin, Tianjin Municipality, 300052, China
Union Hospital Tongji Medical College Huazhong University of Science and Technology
RECRUITING

Wuhan, Hubei, 430022, China
Xuzhou Central Hospital
COMPLETED

Xuzhou, Jiangsu, 221009, China
Yantai Yuhuangding Hospital
COMPLETED

Yantai, Shandong, 264000, China
Yijishan Hospital of Wannan Medical College
RECRUITING

Wuhu, Anhui, 241001, China
Zhongda Hospital, Affiliated to Southeast University
RECRUITING

Nanjing, Jiangsu, 210009, China
Zhongshan Hospital Fudan University
COMPLETED

Shanghai, Shanghai Municipality, 200022, China

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