New pill could tame gut inflammation in Crohn's patients

NCT ID NCT06233461

Recruiting now Disease control Sponsor: Takeda Source: ClinicalTrials.gov ↗

First seen Oct 31, 2025 · Last updated May 14, 2026 · Updated 18 times

Summary

This study tests an oral drug called TAK-279 in 268 adults with moderate to severe Crohn's disease who haven't responded well to other treatments. The main goal is to see if three different doses can reduce bowel inflammation and ulcers after 12 weeks compared to a placebo. Participants will take the drug for a year and have 15 clinic visits, including an endoscopy to check their gut.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Changhua, Changhua County, 50006, Taiwan

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Taichung, 40447, Taiwan

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Mentor, Ohio, 44060, United States

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Hvidovre, 2650, Denmark

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Daegu, 42601, South Korea

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Las Vegas, Nevada, 89128, United States

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Ústí nad Labem, 40113, Czechia

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Sliven, 8800, Bulgaria

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Epping, 3076, Australia

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Milan, 20132, Italy

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Budapest, 1082, Hungary

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Shanghai, 201318, China

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Nedlands, 6009, Australia

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São Paulo, 01307-002, Brazil

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Beersheba, 84101, Israel

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Athens, 11527, Greece

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San Antonio, Texas, 78229, United States

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Spital Clinic Dr I Cantacuzino
RECRUITING

Bucharest, 020475, Romania

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Spitalul Euroclinic
RECRUITING

Bucharest, 14461, Romania

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St Thomas' Hospital - Guy's & St Thomas' NHS Foundation Trust
RECRUITING

London, SE1 7EH, United Kingdom

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St. Elisabeth Ziekenhuis
RECRUITING

Tilburg, 5022 GC, Netherlands

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St. Marien- und St. Annastiftskrankenhaus
RECRUITING

Ludwigshafen, 67065, Germany

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Sun Yat-sen University (SYSU) - The First Affiliated Hospital
RECRUITING

Guangzhou, Guangdong, 510080, China

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Sun Yat-sen University - The Sixth Affiliated Hospital (Guangdong Gastrointestinal Hospital)
RECRUITING

Guangzhou, 510655, China

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SurGal Clinic SRO
RECRUITING

Brno, 602 00, Czechia

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Sydvestjysk Region/Esbjerg Hospital
RECRUITING

Esbjerg, 6700, Denmark

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TDDC dba Alliance Research
COMPLETED

Mansfield, Texas, 76063, United States
Texas Digestive Disease Consultants, PLLC d/b/a GI Alliance
COMPLETED

Fort Worth, Texas, 76104, United States
The Chaim Sheba Medical Center - The Edmond and Lily Safra Children's Hospital
RECRUITING

Ramat Gan, 5265601, Israel

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The Chaim Sheba Medical Centre
RECRUITING

Tel Aviv, 5265601, Israel

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The First Affiliated Hospital of Zhejiang Chinese Medical University
NOT_YET_RECRUITING

Zhejiang, 310006, China

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The Jikei University Hospital
RECRUITING

Minato, Tokyo, 105-8471, Japan

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The Queen Elizabeth Hospital
RECRUITING

Woodville, South Australia, 5011, Australia

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The Research Institute of the McGill University Health Center
RECRUITING

Montreal, Quebec, H3G 1A4, Canada

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The Second Affiliated Hospital of Soochow University
NOT_YET_RECRUITING

Suzhou, Jiangsu, 215004, China

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The Second Affiliated Hospital of Zhejiang University School of Medicine
RECRUITING

Hangzhou, Zhejiang, 310009, China

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The Second People's Hospital of Changzhou
NOT_YET_RECRUITING

Changzhou, Jiangsu, China

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The Second Xiangya Hospital of Central South University
RECRUITING

Changsha, Hunan, 410011, China

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The University of Iowa Hospitals & Clinics
RECRUITING

Iowa City, Iowa, 52242, United States

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Tohoku University Hospital
RECRUITING

Sendai, Miyagi, 980-8574, Japan

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Toyama University Hospital
RECRUITING

Toyama, 930-0194, Japan

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Tsujinaka Hospital Kashiwanoha
RECRUITING

Chiba, 277-0871, Japan

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Twoja Przychodnia - Szczecinskie Centrum Medyczne
RECRUITING

Szczecin, West Pomeranian Voivodeship, 71-434, Poland

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Tyler Research Institute, LLC
RECRUITING

Tyler, Texas, 75701, United States

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UCI Health
RECRUITING

Orange, California, 92868, United States

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UMBAL Kaspela
RECRUITING

Plovdiv, 4001, Bulgaria

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USF Health Morsani Center for Advanced Healthcare
RECRUITING

Tampa, Florida, 33612, United States

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United Medical Doctors
RECRUITING

Murrieta, California, 92563, United States

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Universidade Estadual Paulista Julio De Mesquita Filho (Unesp) - Faculdade de Medicina de Botucatu
NOT_YET_RECRUITING

Botucatu, São Paulo, 18618-970, Brazil

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Universidade Estadual de Campinas - UNICAMP
NOT_YET_RECRUITING

Campinas, São Paulo, 13083-887, Brazil

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Universitaetsklinik Frankfurt
RECRUITING

Frankfurt, 60590, Germany

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Universitaetsklinikum Mannheim GmbH
RECRUITING

Mannheim, 68167, Germany

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Universitaetsklinikum Schleswig-Holstein, UKSH-Campus Kiel
RECRUITING

Kiel, 24105, Germany

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Universitaetsklinikum Tuebingen
RECRUITING

Tübingen, 72076, Germany

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Universitair Ziekenhuis Leuven
RECRUITING

Leuven, 3000, Belgium

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University Gastroenterology Providence
RECRUITING

Providence, Rhode Island, 02904, United States

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University General Hospital of Patras
RECRUITING

Pátrai, Achaia, 26504, Greece

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University Hospital Basel
RECRUITING

Basel, 4031, Switzerland

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University Hospital Brno
RECRUITING

Brno, 639 00, Czechia

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University Hospital Of Ulm, Universitatsklinikum Ulm
RECRUITING

Ulm, 89081, Germany

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University Hospital Tsaritsa Yoanna - Isul (University Hospital Queen Giovanna)
RECRUITING

Sofia, 1527, Bulgaria

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University Hospital of Heraklion
RECRUITING

Heraklion, Crete, 71110, Greece

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University Of Louisville
RECRUITING

Louisville, Kentucky, 40202, United States

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University of Athens School of Medicine, Alexandra General Hospital
RECRUITING

Athens, Attica, 11528, Greece

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University of Kansas Medical Center
NOT_YET_RECRUITING

Kansas City, Kansas, 66160, United States

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University of Toronto - Mount Sinai Hospital - The Lunenfeld-Tanenbaum Research Institute
RECRUITING

Toronto, Ontario, M5G 1X5, Canada

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University of Washington Medical Center
RECRUITING

Seattle, Washington, 98195, United States

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Vojenska Nemocnice Brno
RECRUITING

Brno, 636 00, Czechia

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WIP Warsaw IBD Point Profesor Kierkus
RECRUITING

Warsaw, 04-501, Poland

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Wellness Clinical Research
RECRUITING

Miami Lakes, Florida, 33016, United States

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West Central Gastroenterology, LLP, d/b/a/ Gastro Florida
RECRUITING

Clearwater, Florida, 33762, United States

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Western Health/Footscray Hospital
RECRUITING

Melbourne, Victoria, 3011, Australia

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Wingate Institute for Neurogastroenterology, Wingate Clinical Trials Facility, Barts Health NHS Trust
RECRUITING

London, E1 2at, E1 2AT, United Kingdom

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Woodholme Gastroenterology Associates
RECRUITING

Glen Burnie, Maryland, 21061, United States

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Wuhan University - Renmin Hospital (Hubei General Hospital)
NOT_YET_RECRUITING

Wuhan, Hubei, 430060, China

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Yonsei University Wonju Severance Christian Hospital
RECRUITING

Wŏnju, Gangwon-do, 26426, South Korea

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Zhejiang University School of Medicine - Sir Run Run Shaw Hospital (SRRSH)
RECRUITING

Hangzhou, 310016, China

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Zhongshan Hospital Xiamen University
RECRUITING

Xiamen, Fujian, 361000, China

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Zuyderland Medisch Centrum - Sittard-Geleen
RECRUITING

Geleen, Limburg, 6162 BG, Netherlands

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Conditions

Explore the condition pages connected to this study.

CROHN'S DISEASE