New pill TAK-279 aims to tame Crohn's Flare-Ups

NCT ID NCT06233461

Recruiting now Disease control Sponsor: Takeda Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 07, 2026 · Updated 2 times

Summary

This study tests an oral drug called TAK-279 (Zasocitinib) in 268 adults with moderate-to-severe Crohn's disease who haven't responded well to other treatments. Participants take one of three doses or a placebo daily for 12 weeks to see if it reduces gut inflammation and ulcers, as seen by endoscopy. The goal is to find a new option to control this long-term condition.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: TAK-279 (also called Zasocitinib), an oral capsule
What this could lead to: If it works, this could point toward a new daily pill to control Crohn's disease inflammation and reduce symptoms.
What could go wrong: This is an early Phase 2b trial with only 268 people, so results may not apply to everyone. The drug may not work better than placebo, and side effects are still being studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Crohn disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CROHN'S DISEASE

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

A. Gemelli University Hospital, Catholic University of the Sacred Heart
RECRUITING

Roma, 00168, Italy
Aalborg Hospital
RECRUITING

Aalborg, 9100, Denmark
Accout Center, s.r.o.- Gastroenterologicka ambulancia
RECRUITING

Šahy, 936 01, Slovakia

Contact Email: •••••@•••••
Acibadem City Clinic Mladost Hospital
RECRUITING

Sofia, 1784, Bulgaria
Acibadem City clinic Tokuda hospital
RECRUITING

Sofia, 1407, Bulgaria
Addenbrooke's Hospital - Cambridge University Hospitals NHS Foundation Trust
RECRUITING

Cambridge, Cambridgeshire, CB2 0QQ, United Kingdom
AdventHealth (Florida Hospital) Medical Group
NOT_YET_RECRUITING

Orlando, Florida, 32804, United States
Agaplesion Markus Krankenhaus
RECRUITING

Frankfurt am Main, 60431, Germany
Akershus University Hospital
RECRUITING

Lorenskog, Akershus, 1478, Norway
AmiCare Sp. z o.o. Sp. k.
RECRUITING

Lodz, Łódź Voivodeship, 91-495, Poland
Amsterdam University Medical Center (Amsterdam UMC), Vrije University Medical Center (VUMC)
RECRUITING

Amsterdam, 1081, Netherlands
Asan Medical Center (AMC)
RECRUITING

Seoul, 05505, South Korea
Atlanta Center For Gastroenterology, P.C.
RECRUITING

Decatur, Georgia, 30033, United States
Auzmer Research
RECRUITING

Lakeland, Florida, 33813, United States
Axon Clinical s.r.o.
RECRUITING

Prague, 15000, Czechia
Azienda Ospedaliera Ospedali Riuniti Villa Sofia Cervello
RECRUITING

Palermo, 90146, Italy
Azienda Ospedaliera San Camillo Forlanini
RECRUITING

Rome, 00152, Italy
BVL Clinical Research
RECRUITING

Liberty, Missouri, 64068, United States
CHU De Clermont Ferrand - Hopital Estaing
RECRUITING

Clermont-Ferrand, 63000, France
CHU Saint-Pierre - Porte de Hal
RECRUITING

Brussels, 1000, Belgium
Centre Hospital Regional Et Universitaire De Tours (Chru Tours) - Houpital Trousseau
RECRUITING

Chambray-lès-Tours, 37170, France
Centre Hospitalier Regional Universitaire de Nancy, Hopital Brabois
RECRUITING

Vandœuvre-lès-Nancy, 54511, France
Centre Hospitalier Universitaire (CHU) de Liege - Domaine Universitaire du Sart Tilman
RECRUITING

Liège, 4000, Belgium
Centre Hospitalier de l'Universite de Montreal
RECRUITING

Montreal, Quebec, H2X 0A9, Canada
Centro de Estudos Clnicos do Interior Paulista (CECIP)
NOT_YET_RECRUITING

Jaú, São Paulo, 17201-130, Brazil
Centrum Badan Klinicznych
RECRUITING

Wroclaw, 51-162, Poland
Centrum Medyczne Medyk Sp. z o.o. Sp. K.
RECRUITING

Rzeszów, 35-326, Poland
Centrum Medyczne Melita Medical
RECRUITING

Wroclaw, Lower Silesian Voivodeship, 50-449, Poland
Changhua Christian Hospital
RECRUITING

Changhua, Changhua County, 50006, Taiwan
China Medical University (CMU) - Shengjing Hospital (The Second Affiliated Hospital) - Huaxiang Campus
RECRUITING

Shenyang, Liaoning, 110022, China
China Medical University Hospital
RECRUITING

Taichung, 40447, Taiwan
Chongqing General Hospital
RECRUITING

Chongqing, Chongqing Sheng, 400013, China
Clinexpert
RECRUITING

Budapest, 1033, Hungary
Clinica Medicum
RECRUITING

Bucharest, 012015, Romania
Clinical Hospital Colentina-Spitalul Clinic Colentina
RECRUITING

Bucharest, 0 50159, Romania
Cliniq s. r. o.
RECRUITING

Bratislava, 811 09, Slovakia
Concord Repatriation General Hospital
RECRUITING

Sydney, New South Wales, 2139, Australia
Diagnostic-Consultative Center Aleksandrovska EOOD
RECRUITING

Sofia, 1431, Bulgaria
Digestive Disease Institute, Shaare Zedek Medical Center
RECRUITING

Jerusalem, 9103102, Israel
ETG Zamosc
RECRUITING

Zamość, 22400, Poland
Emory University Hospital, The Emory Clinic
RECRUITING

Atlanta, Georgia, 30322, United States
EndoArt
RECRUITING

Ostrava, 71000, Czechia
Endohope Clinic
RECRUITING

Prague, 10100, Czechia
Endomed
RECRUITING

Košice, 4013, Slovakia
Evangelismos Hospital
RECRUITING

Athens, Attica, 106 76, Greece
Fakultna Nemocnica s poliklinikou Nove Zamky
RECRUITING

Nové Zámky, 94034, Slovakia

Contact Email: •••••@•••••
Fakultna nemocnica F. D. Roosevelta
RECRUITING

Banská Bystrica, 97401, Slovakia
Fakultni Nemocnice Ostrava (FNO)
RECRUITING

Ostrava-Poruba, 708 52, Czechia
Flinders Medical Centre
RECRUITING

Bedford Park, South Australia, 5042, Australia
Fraser Clinical Trials
RECRUITING

New Westminster, British Columbia, V3L 3W4, Canada
Fukuoka University Hospital
RECRUITING

Fukuoka, 814-0180, Japan
G.N.A. Gennimatas
RECRUITING

Athens, 15669, Greece
GI PROS, Inc.
RECRUITING

Naples, Florida, 34102, United States
Galileo Medical Research
NOT_YET_RECRUITING

Juiz de Fora, Minas Gerais, 36033-318, Brazil
Gastroenterology Associates, PA
RECRUITING

Greenville, South Carolina, 29615, United States
Gastromed Kopon, Zmudzinski i Wspolnicy Sp.j. Specjalistyczne Centrum Gastrologii i Endoskopii Specjalistyczne Gabinety Lekarskie
RECRUITING

Torun, Kujawsko-pomo, 87-100, Poland
Gastromedic s.r.o
RECRUITING

Pardubice, 530 03, Czechia
Great Lakes Gastroenterology Research, LLC
RECRUITING

Mentor, Ohio, 44060, United States
H-T. Centrum Medyczne Sp. z o.o. Sp.k.
RECRUITING

Tychy, 43-100, Poland
Hamamatsu University Hospital
RECRUITING

Hamamatsu, Shizuoka, 431-3192, Japan
Harry Perkins Medical Research Institute Fiona Stanley Hospital
RECRUITING

Murdoch, Western Australia, 6150, Australia
Hepato-Gastroenterologie HK, s.r.o.
RECRUITING

Hradec Králové, 50012, Czechia
Heritage Medical Research Clinic - University Of Calgary
RECRUITING

Calgary, Alberta, T2N 4Z6, Canada
Hillerod Hospital, Hilleroed Sygehus
RECRUITING

Hillerød, 3400, Denmark
Hopital Nord Chu Saint-Etienne
RECRUITING

Saint-Etienne, 42055, France
Hopital Universitaire de Bruxelles/ Academisch Ziekenhuis Brussel
RECRUITING

Brussels, Anderlecht / Region Capitale de Bruxelles/ Brussel, 1070, Belgium
Hopital l'Archet 2
RECRUITING

Nice, 06202, France
Hospital de Clinicas de Porto Alegre (HCPA)
NOT_YET_RECRUITING

Porto Alegre, Rio Grande do Sul, 90035-903, Brazil
Huizhou First Hospital
NOT_YET_RECRUITING

Huizhou, Guangdong, 516001, China
Hvidovre Hospital Medicinsk Gastroenterologisk Afdeling
RECRUITING

Hvidovre, 2650, Denmark
Hyogo Medical University Hospital
RECRUITING

Nishinomiya, Hyōgo, 663-8501, Japan
IRCCS - AOU di Bologna - SantOrsola Malpighi
RECRUITING

Bologna, 40138, Italy
IRCCS Istituto clinico humanitas - Humanitas Mirasole spa
RECRUITING

Rozzano, 20089, Italy

Contact Email: •••••@•••••
Icahn School of Medicine at Mount Sinai (ISMMS) - The Mount Sinai Hospital (MSH)
RECRUITING

New York, New York, 10029, United States
Inje University Haeundae Paik Hospital
RECRUITING

Busan, 48108, South Korea
Institute of Science Tokyo Hospital
RECRUITING

Tokyo, 113-8519, Japan
Institutul Clinic Fundeni
RECRUITING

Bucharest, 022328, Romania
Intesto - Gastroenterologische Praxis & Crohn-Colitis-Zentrum Bern
RECRUITING

Bern, 3012, Switzerland
Irmandade da Santa Casa da Misericordia de Santos
NOT_YET_RECRUITING

Santos, São Paulo, 11075-900, Brazil
Iwate Medical University Uchimaru Medical Center
RECRUITING

Morioka, Iwate, 020-8505, Japan
Kansai Medical University Hospital
RECRUITING

Hirakata, Osaka, 5731191, Japan
Keimyung University Dongsan Hospital
RECRUITING

Daegu, 42601, South Korea
Korczowski Bartosz, Gabinet Lekarski
RECRUITING

Rzeszów, 35302, Poland
Kosin University Gospel Hospital
RECRUITING

Busan, 49267, South Korea
Kyorin University Hospital
RECRUITING

Mitaka, Tokyo, 181-8611, Japan
L2 IP - Instituto de Pesquisas Clinicas LTDA
NOT_YET_RECRUITING

Brasília, Federal District, 70200-730, Brazil
Las Vegas Medical Research
RECRUITING

Las Vegas, Nevada, 89128, United States
London Health Sciences Centre - University Hospital
RECRUITING

London, Ontario, N6A 5A5, Canada
London Health Sciences Centre - Victoria Hospital
RECRUITING

London, Ontario, N6A 5W9, Canada
Manermed Sp. z o.o - CM Medis
RECRUITING

Bydgoszcz, 85229, Poland
Masaryk Hospital
NOT_YET_RECRUITING

Ústí nad Labem, 40113, Czechia
Mater Cancer Care Centre-Mater Health Services
RECRUITING

South Brisbane, Queensland, 4101, Australia
Medrise sp. z o.o
RECRUITING

Lublin, 20-582, Poland
Meir Medical Center
RECRUITING

Kfar Saba, 44281, Israel
Mohacsi Korhaz
RECRUITING

Mohács, 7700, Hungary
Multi-Profile Hospital for Active Treatment (MHAT) Hadji Dimitar
RECRUITING

Sliven, 8800, Bulgaria
NH Hospital
RECRUITING

Hořovice, Central Bohemia, 268 31, Czechia
National Taiwan University Hospital
RECRUITING

Taipei, Zhongzheng District, 100, Taiwan
Nemocnice Ceske Budejovice, a.s.
NOT_YET_RECRUITING

České Budějovice, 370 01, Czechia
Northern Hospital Epping
RECRUITING

Epping, 3076, Australia
Nova Scotia Health Authority - Queen Elizabeth II Heath Sciences Centre
RECRUITING

Halifax, Nova Scotia, B3H 2Y9, Canada
Novel Research, LLC
RECRUITING

Bellaire, Texas, 77401, United States
Odense Universitetshospital (OUH) (Odense University Hospital)
RECRUITING

Odense, Region Syddanmark, 5000, Denmark
One of a Kind Clinical research Center TX LLC
NOT_YET_RECRUITING

Kingwood, Texas, 77339, United States
Osaka Medical College Hospital
RECRUITING

Takatsuki-shi, Osaka, 569-8686, Japan
Oslo Univeristy Hospital Ulleval Hospital
RECRUITING

Oslo, 0450, Norway
Ospedale San Raffaele (HSR) Instituto Scientifico Universitario San Raffaele
RECRUITING

Milan, 20132, Italy
Pannonia Maganorvosi Centrum Kft.
RECRUITING

Budapest, 1136, Hungary
Panstwowy Instytut Medyczny MSWiA
RECRUITING

Warsaw, Masovian Voivodeship, 02-507, Poland
PlanetMed Sp. z o.o.
COMPLETED

Wroclaw, Lower Silesian Voivodeship, 52-210, Poland
Policlinica Algomed: Centrul De Gastroenterologie Dr. Goldis
RECRUITING

Timișoara, Jud Timis, 300002, Romania
Region Sjaelland Sygehus Nord, Koge Sygehus
RECRUITING

Køge, 4600, Denmark
Renji Hospital Shanghai Jiao Tong University School of Medicine
RECRUITING

Shanghai, Shanghai Municipality, 200127, China

Contact Email: •••••@•••••
Ribeiralo Preto Medical School, University of Salo Paulo
NOT_YET_RECRUITING

Ribeirão Preto, São Paulo, 14048-900, Brazil
Rochester Clinical Research
RECRUITING

Rochester, New York, 14609, United States
Royal Perth Hospital
RECRUITING

Perth, Western Australia, 6000, Australia
Samsung Medical Center
RECRUITING

Seoul, 06351, South Korea
Sapporo Medical University Hospital
RECRUITING

Sapporo, Hokkaido, 060-8543, Japan
Semmelweis Egyetem
RECRUITING

Budapest, 1082, Hungary
Severance Hospital, Yonsei University Health System
RECRUITING

Seoul, 03722, South Korea
Shanghai East Hospital
NOT_YET_RECRUITING

Shanghai, Shanghai Municipality, 200120, China
Shanghai Pudong New District Zhoupu Hospital
RECRUITING

Shanghai, 201318, China
Sir Charles Gairdner Hospital (SCGH) - Comprehensive Cancer Centre
RECRUITING

Nedlands, 6009, Australia
Solare Trials
NOT_YET_RECRUITING

São Paulo, 01307-002, Brazil
Soroka Mc
RECRUITING

Beersheba, 84101, Israel
Sotiria General Hospital of Athens
RECRUITING

Athens, 11527, Greece
South Eastern Health and Social Care Trust - The Ulster Hospital
RECRUITING

Belfast, BT16 1RH, United Kingdom
Southern Star Research Institute, LLC
RECRUITING

San Antonio, Texas, 78229, United States
Spital Clinic Dr I Cantacuzino
RECRUITING

Bucharest, 020475, Romania
Spitalul Euroclinic
RECRUITING

Bucharest, 14461, Romania
St Thomas' Hospital - Guy's & St Thomas' NHS Foundation Trust
RECRUITING

London, SE1 7EH, United Kingdom
St. Elisabeth Ziekenhuis
RECRUITING

Tilburg, 5022 GC, Netherlands
St. Marien- und St. Annastiftskrankenhaus
RECRUITING

Ludwigshafen, 67065, Germany
Sun Yat-sen University (SYSU) - The First Affiliated Hospital
RECRUITING

Guangzhou, Guangdong, 510080, China
Sun Yat-sen University - The Sixth Affiliated Hospital (Guangdong Gastrointestinal Hospital)
RECRUITING

Guangzhou, 510655, China
SurGal Clinic SRO
RECRUITING

Brno, 602 00, Czechia
Sydvestjysk Region/Esbjerg Hospital
RECRUITING

Esbjerg, 6700, Denmark
TDDC dba Alliance Research
COMPLETED

Mansfield, Texas, 76063, United States
Texas Digestive Disease Consultants, PLLC d/b/a GI Alliance
COMPLETED

Fort Worth, Texas, 76104, United States
The Chaim Sheba Medical Center - The Edmond and Lily Safra Children's Hospital
RECRUITING

Ramat Gan, 5265601, Israel
The Chaim Sheba Medical Centre
RECRUITING

Tel Aviv, 5265601, Israel
The First Affiliated Hospital of Zhejiang Chinese Medical University
NOT_YET_RECRUITING

Zhejiang, 310006, China
The Jikei University Hospital
RECRUITING

Minato, Tokyo, 105-8471, Japan
The Queen Elizabeth Hospital
RECRUITING

Woodville, South Australia, 5011, Australia
The Research Institute of the McGill University Health Center
RECRUITING

Montreal, Quebec, H3G 1A4, Canada
The Second Affiliated Hospital of Soochow University
NOT_YET_RECRUITING

Suzhou, Jiangsu, 215004, China
The Second Affiliated Hospital of Zhejiang University School of Medicine
RECRUITING

Hangzhou, Zhejiang, 310009, China
The Second People's Hospital of Changzhou
NOT_YET_RECRUITING

Changzhou, Jiangsu, China
The Second Xiangya Hospital of Central South University
RECRUITING

Changsha, Hunan, 410011, China
The University of Iowa Hospitals & Clinics
RECRUITING

Iowa City, Iowa, 52242, United States
Tohoku University Hospital
RECRUITING

Sendai, Miyagi, 980-8574, Japan
Toyama University Hospital
RECRUITING

Toyama, 930-0194, Japan
Tsujinaka Hospital Kashiwanoha
RECRUITING

Chiba, 277-0871, Japan
Twoja Przychodnia - Szczecinskie Centrum Medyczne
RECRUITING

Szczecin, West Pomeranian Voivodeship, 71-434, Poland
Tyler Research Institute, LLC
RECRUITING

Tyler, Texas, 75701, United States
UCI Health
RECRUITING

Orange, California, 92868, United States
UMBAL Kaspela
RECRUITING

Plovdiv, 4001, Bulgaria
USF Health Morsani Center for Advanced Healthcare
RECRUITING

Tampa, Florida, 33612, United States
United Medical Doctors
RECRUITING

Murrieta, California, 92563, United States
Universidade Estadual Paulista Julio De Mesquita Filho (Unesp) - Faculdade de Medicina de Botucatu
NOT_YET_RECRUITING

Botucatu, São Paulo, 18618-970, Brazil
UniversidadeEstadualde Campinas - UNICAMP
NOT_YET_RECRUITING

Campinas, São Paulo, 13083-887, Brazil
Universitaetsklinik Frankfurt
RECRUITING

Frankfurt, 60590, Germany
Universitaetsklinikum Mannheim GmbH
RECRUITING

Mannheim, 68167, Germany
Universitaetsklinikum Schleswig-Holstein, UKSH-Campus Kiel
RECRUITING

Kiel, 24105, Germany
Universitaetsklinikum Tuebingen
RECRUITING

Tübingen, 72076, Germany
Universitair Ziekenhuis Leuven
RECRUITING

Leuven, 3000, Belgium
University Gastroenterology Providence
RECRUITING

Providence, Rhode Island, 02904, United States
University General Hospital of Patras
RECRUITING

Pátrai, Achaia, 26504, Greece
University Hospital Basel
RECRUITING

Basel, 4031, Switzerland
University Hospital Brno
RECRUITING

Brno, 639 00, Czechia
University Hospital Of Ulm, Universitatsklinikum Ulm
RECRUITING

Ulm, 89081, Germany
University Hospital Tsaritsa Yoanna - Isul (University Hospital Queen Giovanna)
RECRUITING

Sofia, 1527, Bulgaria
University Hospital of Heraklion
RECRUITING

Heraklion, Crete, 71110, Greece
University Of Louisville
RECRUITING

Louisville, Kentucky, 40202, United States
University of Athens School of Medicine, Alexandra General Hospital
RECRUITING

Athens, Attica, 11528, Greece
University of Kansas Medical Center
NOT_YET_RECRUITING

Kansas City, Kansas, 66160, United States
University of Toronto - Mount Sinai Hospital - The Lunenfeld-Tanenbaum Research Institute
RECRUITING

Toronto, Ontario, M5G 1X5, Canada
University of Washington Medical Center
RECRUITING

Seattle, Washington, 98195, United States
Vojenska Nemocnice Brno
RECRUITING

Brno, 636 00, Czechia
WIP Warsaw IBD Point Profesor Kierkus
RECRUITING

Warsaw, 04-501, Poland
Wellness Clinical Research
RECRUITING

Miami Lakes, Florida, 33016, United States
West Central Gastroenterology, LLP, d/b/a/ Gastro Florida
RECRUITING

Clearwater, Florida, 33762, United States
Western Health/Footscray Hospital
RECRUITING

Melbourne, Victoria, 3011, Australia
Wingate Institute for Neurogastroenterology, Wingate Clinical Trials Facility, Barts Health NHS Trust
RECRUITING

London, E1 2at, E1 2AT, United Kingdom
Woodholme Gastroenterology Associates
RECRUITING

Glen Burnie, Maryland, 21061, United States
Wuhan University - Renmin Hospital (Hubei General Hospital)
NOT_YET_RECRUITING

Wuhan, Hubei, 430060, China
Yonsei University Wonju Severance Christian Hospital
RECRUITING

Wŏnju, Gangwon-do, 26426, South Korea
Zhejiang University School of Medicine - Sir Run Run Shaw Hospital (SRRSH)
RECRUITING

Hangzhou, 310016, China
Zhongshan Hospital Xiamen University
RECRUITING

Xiamen, Fujian, 361000, China
Zuyderland Medisch Centrum - Sittard-Geleen
RECRUITING

Geleen, Limburg, 6162 BG, Netherlands

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