Double-Drug attack on Crohn's: could two biologics be better than one?
NCT ID NCT06045754
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study is testing whether combining two different biologic drugs can better control moderate to severe Crohn's disease. One hundred adults will first receive either vedolizumab plus adalimumab or vedolizumab plus ustekinumab. Those who respond well will then switch to vedolizumab alone. The goal is to see if the combination improves bowel healing and symptoms, and if the benefit can be maintained with a single drug.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
vedolizumab (Entyvio), adalimumab (Humira), ustekinumab (Stelara)
What this could lead to
If successful, this could show that combining two targeted therapies is safe and effective for controlling moderate to severe Crohn's disease, and that some patients may then maintain control with just one drug.
What could go wrong
This is a small, early-phase 4 study with only 100 participants, so results may not apply to everyone. Combining two powerful immune-suppressing drugs also raises the risk of serious infections and other side effects.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
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Locations
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ABP Research Services Corp.
RECRUITINGOakville, Ontario, L6L 5L7, Canada
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Allegheny Health Network
RECRUITINGWexford, Pennsylvania, 15090, United States
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Alliance Clinical Research of Tampa, LLC
RECRUITINGTampa, Florida, 33615, United States
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BVL Clinical Research
RECRUITINGLiberty, Missouri, 64068, United States
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Cedars-Sinai Medical Center
RECRUITINGLos Angeles, California, 90048, United States
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Clinical Research of Osceola
RECRUITINGKissimmee, Florida, 34741, United States
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Cotton ONeil Clinical Research Center
RECRUITINGTopeka, Kansas, 66606, United States
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Covenant Health
RECRUITINGEdmonton, Alberta, T5K 2K4, Canada
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Digestive Disease Specialists, Inc.
RECRUITINGOklahoma City, Oklahoma, 73114, United States
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Digestive Health Specialsits
RECRUITINGDothan, Alabama, 36301, United States
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Endoscopic Research Inc
RECRUITINGOrlando, Florida, 32803, United States
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GI Alliance
RECRUITINGMetairie, Louisiana, 70006, United States
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GI Alliance - Digestive Health Associates of Texas
RECRUITINGDallas, Texas, 75044, United States
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GI Alliance - Illinois Gastroenterology Group - Glenview
RECRUITINGGlenview, Illinois, 60026, United States
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GI Alliance - Illinois Gastroenterology Group LLC - Gurnee
RECRUITINGGurnee, Illinois, 60031, United States
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GI Alliance - Mansfield
RECRUITINGMansfield, Texas, 76063, United States
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GI Alliance - Webster
RECRUITINGWebster, Texas, 77598, United States
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GI Alliance Sun City
RECRUITINGSun City, Arizona, 85351, United States
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Gastro Intestinal Research Institute of Northern Ohio, LLC.
RECRUITINGWestlake, Ohio, 44145, United States
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Gastroenterology Consultants, P.C.
RECRUITINGRoswell, Georgia, 30076, United States
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Gastroenterology Research of San Antonio, LLC
RECRUITINGSan Antonio, Texas, 78229, United States
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Great Lakes Gastroenterology Research, LLC
RECRUITINGMentor, Ohio, 44060, United States
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Hoag Hospital Newport Beach
RECRUITINGNewport Beach, California, 92663, United States
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Huron Gastroenterology Associates, P.C.
RECRUITINGYpsilanti, Michigan, 48197, United States
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London Health Sciences Centre
RECRUITINGLondon, Ontario, N6A 5A5, Canada
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Medical Research Center of Connecticut, LLC
RECRUITINGHamden, Connecticut, 06518, United States
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Mid-America Gastro-Intestinal Consultants
RECRUITINGKansas City, Missouri, 64111, United States
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NYU Langone Health
RECRUITINGNew York, New York, 10016, United States
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Ohio Gastroenterology group, Inc.
RECRUITINGColumbus, Ohio, 43202, United States
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Rapid City Medical Center, LLP
RECRUITINGRapid City, South Dakota, 57701, United States
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Southern Star Research Institute, LLC.
RECRUITINGSan Antonio, Texas, 78229, United States
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Taunton Surgical Centre
WITHDRAWNOshawa, Ontario, L1J 0C7, Canada
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Texas Digestive Disease Consultants (TDDC), Southlake
RECRUITINGSouthlake, Texas, 76092, United States
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Texas Digestive Disease Consultants Cedar Park
RECRUITINGCedar Park, Texas, 78613, United States
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Texas Digestive Disease Consultants Lubbock
RECRUITINGLubbock, Texas, 79410, United States
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The Research Institute of the McGill University Health Centre
RECRUITINGMontreal, Quebec, H3G 1A4, Canada
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The University of Texas Health Science Center at Houston
RECRUITINGHouston, Texas, 77030, United States
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Toronto Digestive Disease Associates (TDDA) Inc.
RECRUITINGVaughan, Ontario, L4L 4Y7, Canada
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Toronto Immune and Digestive Health Institute Inc. (TIDHI)
RECRUITINGNorth York, Ontario, M6A3B4, Canada
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Tulane University
RECRUITINGNew Orleans, Louisiana, 70112, United States
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Tyler Research Institute, LLC
RECRUITINGTyler, Texas, 75701, United States
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University Gastroenterology
RECRUITINGProvidence, Rhode Island, 02905, United States
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University of California San Diego Health (UCSD)
RECRUITINGLa Jolla, California, 92037, United States
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University of Chicago Medicine
RECRUITINGChicago, Illinois, 60637, United States
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University of Cincinnati
RECRUITINGCincinnati, Ohio, 45627, United States
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University of Kansas Medical Center
RECRUITINGKansas City, Kansas, 66160, United States
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University of Louisville
RECRUITINGLouisville, Kentucky, 40202, United States
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University of South Florida
NOT_YET_RECRUITINGTampa, Florida, 33612, United States
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University of Utah Health
RECRUITINGSalt Lake City, Utah, 84108, United States
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Viable Clinical Research - North Bay
RECRUITINGNorth Bay, Ontario, P1B 2H3, Canada
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Washington Gastroenterology- GIA
WITHDRAWNBellevue, Washington, 98004, United States
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Washington Gastroenterology- GIA
RECRUITINGTacoma, Washington, 98405, United States
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Washington University School of Medicine
RECRUITINGSt Louis, Missouri, 63110, United States
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West GTA Endoscopy Inc.
RECRUITINGMississauga, Ontario, L5M 7N4, Canada
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