New surgery may keep Crohn's disease at bay after bowel resection

NCT ID NCT03256240

Recruiting now Disease control Sponsor: Weill Medical College of Cornell University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a newer surgical method called Kono-S anastomosis can better prevent Crohn's disease from returning after bowel surgery compared to the standard side-to-side technique. About 600 adults with Crohn's disease needing bowel resection will be randomly assigned to one of the two procedures. The main goal is to see if the Kono-S method leads to fewer signs of disease recurrence within 6 months and over the long term.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: surgical procedure (Kono-S anastomosis)
What this could lead to: If successful, this could offer a better surgical option to reduce the chance of Crohn's disease coming back after surgery.
What could go wrong: This is a surgical technique comparison, not a new drug. Results may vary, and long-term benefits are still uncertain until the trial completes.

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Conditions

The condition(s) this trial relates to.

Crohn disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CROHN'S DISEASE

Contacts and locations

Locations

Azienda Ospedaliero-Universitaria Careggi
RECRUITING

Florence, Florence, 50134, Italy
Baylor College of Medicine
TERMINATED

Houston, Texas, 77030, United States
Baylor Scott & White Research Institute
TERMINATED

Dallas, Texas, 75204, United States
Charité Campus Benjamin Franklin
RECRUITING

Berlin, 12203, Germany
Helsinki University Hospital
TERMINATED

Helsinki, Helsinki, 00029, Finland
Hospital Universitario Vall d'Hebron
TERMINATED

Barcelona, Barcelona, 08035, Spain
Humanitas University Hospital
RECRUITING

Rozzano, Milan, 20089, Italy
Massachusetts General Hospital
TERMINATED

Boston, Massachusetts, 02114, United States
Policlinico University Hospital
RECRUITING

Naples, Italy
Theresien Hospital and St. Hedwigs Clinic gGmbH
RECRUITING

Mannheim, 68165, Germany
University Clinics Gasthuisberg Herestraat
RECRUITING

Leuven, 3000, Belgium
University of Oklahoma
TERMINATED

Oklahoma City, Oklahoma, 73112, United States
University of Washington Medical Center
TERMINATED

Seattle, Washington, 98195, United States
Universitätsklinik Würzburg
RECRUITING

Würzburg, Wurzburg, D-97080, Germany
Weill Cornell Medical College
RECRUITING

New York, New York, 10065, United States

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