Crohn's patients: switch drug or up dose? new trial seeks answers

NCT ID NCT06180382

Recruiting now Disease control Sponsor: Centre Hospitalier Universitaire de Saint Etienne Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at 220 adults with Crohn's disease whose symptoms returned while on adalimumab. Half will get a higher dose of adalimumab, and the other half will switch to vedolizumab. The goal is to see which approach leads to better control of the disease after 24 weeks, using both symptoms and lab tests.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: vedolizumab and adalimumab
What this could lead to: If it works, this could show that switching to vedolizumab is a better option than simply increasing the dose of adalimumab for Crohn's patients who have stopped responding.
What could go wrong: This is a Phase 4 trial, so the drugs are already approved, but it is still unclear which strategy works best. Results may not apply to all patients, and both drugs carry risks like infection or allergic reactions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Crohn disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CROHN'S DISEASE

Contacts and locations

Locations

APHM
RECRUITING

Marseille, 13000, France
APHP - Hôpital Bicêtre
RECRUITING

Le Kremlin-Bicêtre, PARIS, 94270, France
Assistance Publique - Hôpitaux de Paris
RECRUITING

Paris, 75004, France
CHRU Lille
RECRUITING

Lille, 59037, France
CHU Amiens
RECRUITING

Amiens, 80000, France
CHU Bordeaux
RECRUITING

Pessac, 33604, France
CHU Montpellier
RECRUITING

Montpellier, 34295, France
CHU Rennes
RECRUITING

Rennes, 35033, France
CHU de Saint-Etienne
RECRUITING

Saint-Etienne, 42055, France
Ch Lyon Sud
RECRUITING

Pierre-Bénite, 69230, France
Chu Limoges
RECRUITING

Limoges, 87000, France
Hôpital de l'Archet II
RECRUITING

Nice, 06202, France

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