Centre Hospitalier Universitaire De Saint Etienne

This study looks at whether giving the 20-valent pneumococcal vaccine (PCV-20) to adults while they have a fever is as effective and safe as waiting until they are well. About 1052 adults with certain health risks (like heart or lung disease) will take part. The goal is to see if…

People with chronic myeloid leukemia take tyrosine kinase inhibitors daily, often alongside other medicines, herbs, or supplements that can interfere with how the cancer drug works. Researchers are testing whether a pharmacist-led medication review can identify these interactions…

This study tests whether hydroxychloroquine, a drug already used for lupus, can slow kidney function decline in people with IgA nephropathy (Berger's disease). About 334 adults with biopsy-confirmed IgA nephropathy and high protein in their urine will receive either hydroxychloro…

This study tests whether closely monitoring the amount of sedation and pain medication given during surgery can prevent serious complications like kidney injury, heart problems, and death. It involves 1,132 high-risk patients over 75 or with conditions like heart disease. The goa…

This study tests whether a program of adapted physical activity combined with extra nutrition can help women with constitutional thinness gain lean body mass (muscle). Constitutional thinness is a condition where people are naturally very thin and find it hard to gain weight, eve…

This trial tests whether a new robotic system that uses only one small incision (single port) can safely perform common abdominal surgeries in children. The study includes children aged 1 to 17 who need procedures like pyeloplasty or reflux treatment. The goal is to see if the si…

This study tests whether a purine-rich diet can lower disease markers in people with AICA-ribosiduria, a rare genetic condition causing severe disability and epilepsy. Ten participants will follow a diet with 160 mg of purines per day. Early results in one patient showed promise,…

This study looks for the best way to treat people who have a blood clot (like in the leg or lung) and also take daily aspirin or similar drugs for heart disease. Both conditions need blood thinners, but taking them together raises the risk of dangerous bleeding. The trial will co…

This study tests whether a non-invasive brain stimulation technique called tDCS can reduce cannabis use in people with schizophrenia. 110 motivated participants will receive either real or sham stimulation over 5 days. Researchers will track changes in cannabis consumption, cravi…

This study looks at 220 adults with Crohn's disease whose symptoms returned while on adalimumab. Half will get a higher dose of adalimumab, and the other half will switch to vedolizumab. The goal is to see which approach leads to better control of the disease after 24 weeks, usin…

This study tests a personalized approach to slowly reduce the dose of the biologic drug adalimumab in people with rheumatoid arthritis who are in remission. The goal is to find the best blood level of the drug before each dose reduction to lower the risk of disease flares. 180 ad…

This study tests a program that helps prostate cancer patients become more physically active. It combines a personalized exercise plan, coaching from a fellow patient who is already active, and support from a doctor. The goal is to see if this approach helps men stay active long-…

This phase 3 trial tests whether the drug rituximab can improve disability in people with anti-MAG neuropathy, a rare nerve condition that causes progressive weakness and numbness. The study will enroll 90 participants who have had the disease for 5 years or less and have shown r…

This study aims to create a short, simple questionnaire that doctors can use during routine check-ups to quickly screen childhood cancer survivors for anxiety and depression. About 545 participants aged 6 to 25 who have finished intensive cancer treatment and are in remission wil…

This study is testing a new, non-invasive urine test to detect clear cell renal cell carcinoma, a common type of kidney cancer. Currently, diagnosis often requires expensive imaging or a painful biopsy. Researchers are looking for tiny particles called exosomes in urine that are …

This study is testing whether a simple urine sample can be used instead of a cervical swab to screen for HPV, the virus that causes most cervical cancers. The researchers will collect first-void urine from 350 women aged 30–65 using a special device and compare the results to the…

This study is looking for specific protein patterns in the blood that could help diagnose chronic thromboembolic pulmonary hypertension (CTEPH), a rare but serious complication of blood clots in the lungs. Researchers will analyze blood samples from 120 people suspected of having…

Researchers are studying whether sleeping more for five nights before a night of partial sleep deprivation helps runners maintain their endurance. Sixty-nine healthy, physically active adults will complete a series of incremental running tests to exhaustion under three conditions…

Researchers are testing whether a daily mother-of-pearl powder supplement can slow bone loss in post-menopausal women at risk of osteoporosis. The study enrolls 200 women aged 50 to 65 with mild to moderate bone thinning and no prior fragility fractures. Half receive mother-of-pe…

This study tests whether a personalized, monthly-checked rehab program from 3 to 6 months after ACL surgery can lower the chance of re-tearing the ligament or injuring the other knee. About 432 athletes who want to return to competitive sports will be randomly assigned to either …

This study tests whether adding gentle vibrations to the leg muscles can help people recovering from a stroke walk faster. About 70 patients who had a stroke within the past 3 months will either get real vibrations or a fake treatment during their regular rehab. The goal is to se…

Researchers are studying a 16-session group programme that teaches Dialectical Behaviour Therapy (DBT) skills to people who struggle with emotional dysregulation. Participants attend weekly 2.5-hour sessions in small groups over about five to six months. The study includes adults…

Researchers are testing whether a 3-month program of adapted physical activity and patient education can help adults who have had symptoms attributed to Lyme disease for more than six months. Participants are randomly assigned to either the supervised program, which includes twic…

This study compares a new surgical technique called vNOTES (scarless vaginal surgery using a tiny camera) to standard laparoscopic hysterectomy in 200 women with large uteri (over 280 grams). The goal is to see if vNOTES reduces complications like infections, bleeding, or organ i…

This study tests whether adding acupuncture or a mild nerve stimulation device to an exercise program can reduce fatigue in people with Sjögren's syndrome. About 174 adults with long-term fatigue will be randomly assigned to one of three groups: exercise alone, exercise plus acup…

This study tests a program that combines online educational videos with in-person exercises to help young female athletes (ages 15-22) who experience urinary incontinence during sports. The program focuses on pelvic health education and strengthening the lower back and abdominal …

Researchers are testing whether a home program of breathing and throat muscle exercises can reduce the severity of moderate obstructive sleep apnea. Participants use a handheld resistance device for two sets of 30 breaths, five days a week for three months, and also do guided thr…

Many intensive care patients struggle with anxiety, depression, and post-traumatic stress after a stay in the ICU. Researchers want to know whether a 20-minute visit from a patient's own dog or cat is practical and whether it improves mood. The study enrolls 30 conscious adults w…

This study looks at whether adding hypnosis or relaxation sessions to standard psychological care can lower anxiety in children, teens, and young adults who have finished treatment for pediatric cancer. About 558 participants aged 7 to 25 who are in remission and have anxiety wil…

This pilot study tests whether listening to music in the evening can help people with Alzheimer's disease or related disorders fall asleep faster and behave more calmly. Researchers will compare music therapy to audiobooks in 48 adults living in secure care units. The goal is to …

This pilot study tests whether watching special videos can help people recover leg movement after a stroke. Twelve participants will use a video system that shows their good leg moving, while they try to copy the movement with their affected leg. They will do this 5 times a week …

This study tests whether combining brain stimulation (rTMS) with virtual reality mirror therapy can reduce hard-to-treat nerve pain. 64 adults with chronic neuropathic pain that hasn't responded to drugs will receive either real or sham mirror therapy alongside rTMS. The goal is …

This study tests whether a device that gently stimulates a nerve in the ear (transcutaneous vagus nerve stimulation) can help people with chronic fatigue from fibromyalgia or long COVID get more benefit from exercise. 60 adults who still feel very tired after a standard exercise …

This study tests whether playing familiar music before bedtime can improve sleep and reduce agitation in people with Alzheimer's disease living in special care units. Researchers will use a wrist monitor to track sleep and behavior in 120 participants. The goal is to find a gentl…

This study tests a personalized 6-month program for older adults being treated for bladder or kidney cancer. The program includes exercise sessions and educational workshops before and after surgery. The goal is to see if it can reduce frailty, measured by how far patients can wa…

This study tests whether physical activity in green outdoor spaces reduces negative symptoms (like lack of motivation or social withdrawal) in people with schizophrenia more than indoor exercise. 45 adults aged 18-55 with persistent negative symptoms will participate. Researchers…

This study tests whether a non-invasive brain stimulation technique called rTMS can reduce chronic nerve pain in people with cancer. Sixty participants will receive both real and sham (placebo) stimulation in a crossover design, with an 8-week break in between. The goal is to see…

French guidelines leave the decision to vaccinate during a mild fever up to individual clinicians, and many shots get postponed as a result. This study surveys 630 people, including healthcare professionals who give vaccines and adults from the general public, using an anonymous …

CAR-T cell therapy can cause a serious neurological side effect called ICANS, and researchers do not fully understand how it happens. This study follows 60 adults receiving CAR-T treatment, measuring tiny biological particles called extracellular vesicles in their blood before an…

This study is testing whether MRI brain scans can help predict which patients having their first psychotic episode will not respond to standard treatment. Researchers will scan 80 people aged 18-35 with schizophrenia or related disorders who have never taken antipsychotic medicat…

This study looks at how the blood thinner apixaban works in two groups of people at risk for blood clots: those with newly diagnosed multiple myeloma and those recovering from total knee replacement. Researchers want to see if the drug affects clotting differently in myeloma pati…

Researchers want to know whether making non-verbal sounds such as shouting, growling, or screaming changes how long a person can tolerate pain. Healthy adults place a hand in cold water and keep it there as long as they can, up to five minutes, while researchers measure how quick…

This study looks at whether a special blood test, called a thrombin generation assay, can predict bleeding risk in cancer patients who are taking blood thinners for blood clots. Researchers will follow 212 patients for 6 months, measuring their blood's clotting ability and tracki…

This study is testing a new device called ADHELASKIN to see if it can measure skin stiffness more accurately than the current method (feeling the skin by hand) in people with systemic sclerosis (scleroderma). The study will compare 100 participants: those with scleroderma and hea…

This study explores whether using physical actions, imagined movements, or videos can improve memory in people with early-stage Alzheimer's disease. Researchers will compare recall in 80 older adults (some with Alzheimer's, some healthy) after they watch videos of daily activitie…

This study looks at how stroke patients with weakness on one side use visual and touch feedback when imagining movements. Researchers will record brain activity with EEG while patients perform mental tasks. The goal is to understand how different parts of the brain handle these s…

This study looks at 70 adults with sensory neuronopathy, a rare nerve condition that causes balance and coordination problems. Researchers will test several clinical scales over 12 months to see which one best tracks how the disease changes over time. The goal is to find a reliab…

This study looks at whether muscle measurements from a CT scan taken when a patient is admitted to the ICU for septic shock can predict their risk of dying within 3 months after leaving the ICU. Researchers will analyze muscle size, density, and fat content from the scan and comp…

This study aims to understand why some patients with severe dry eye syndrome improve with autologous serum eye drops while others do not. Researchers will analyze the protein makeup of the drops from 68 participants over 6 months. The goal is to identify which proteins are linked…

This study looks at whether a special nursing care model helps people with long-term health conditions like diabetes, heart disease, or Parkinson's work better with their advanced practice nurse. About 420 adults will take part. The goal is to see if this approach improves how pa…

This study aims to see if completely inactive people can train for 18 months to complete a 100 km mountain ultra-marathon. Researchers will track how many participants stick with the program and finish the race, as well as monitor injuries and overall health. The goal is to under…

This study aims to create better custom insoles for people with rheumatoid arthritis who have foot pain. Researchers will use CT scans and motion analysis to build a digital model of how feet move and apply pressure. The goal is to design insoles that reduce pain and improve comf…

This study looks at how the timing of aerobic exercise—morning versus late afternoon—affects deep sleep and body temperature. Researchers will compare endurance athletes with inactive people to see who is more affected. The goal is to understand how exercise timing can improve sl…

This study looks at whether polishing the inner layer of the cornea before injecting new cells helps remove tiny bumps called guttae in people with Fuchs endothelial corneal dystrophy. Twenty adults scheduled for corneal transplant will have half their cornea polished and the oth…

This study tests whether a small vibrating device placed on the thigh can prevent muscle loss when a leg is immobilized. Forty-two healthy adults will have one leg in a cast for several days. Half will receive daily vibration sessions; the other half will not. Researchers will me…

This study is looking for a better way to track disease activity in people with primary Sjögren's syndrome, a chronic autoimmune disease that causes dryness and can affect organs. Researchers will test a new blood marker called anti-Ro/SSA IgE in 185 participants to see if it is …

This study is looking at how genes relate to the different forms of Fuchs corneal endothelial dystrophy, a common eye disease that affects the cornea. Researchers in France will enroll 500 people who need corneal transplant surgery. They will analyze blood samples for genetic mar…

This study aims to better understand why humans make nonverbal sounds like screams, laughter, and grunts, and how our bodies react when we make them. Researchers will record 2000 participants making various vocal sounds and measure things like heart rate and skin temperature. The…

This study is testing a new way to measure fatigue in people with spinal muscular atrophy (SMA), a condition that causes muscle weakness. The test is designed to be easy enough for patients with different levels of ability. Researchers want to see if the test is safe, doable, and…

This study looks at how hearing sounds like screams, laughter, or crying affects people's thoughts and physical reactions. Researchers will play these sounds to 2000 healthy adults and measure things like heart rate, skin temperature, and how fast they respond. The goal is to bet…

This study looks at whether longer or shorter training sessions help healthy adults maintain their endurance during a 4-hour cycling test. Researchers will measure changes in power output and heart rate. 40 volunteers who exercise up to 2 hours per week will participate.

This study explores how combining mental movement practice (motor imagery) with tendon vibration affects brain activity. Thirty-three healthy adults will try three different timing combinations of vibration and imagery. Researchers will measure brain responses using magnetic stim…

This study looks at whether a short, intense program of local vibration (5 days) can improve leg muscle strength as much as a longer program (4 weeks). 72 healthy adults will try different vibration session lengths (30 or 60 minutes). The goal is to find the most efficient way to…

This study tests a new way to manage alarms in intensive care units (ICUs). Currently, patients trigger hundreds of alarms daily, most of which are false or unimportant. The researchers will compare standard alarm management (left to nurses) with a stricter protocol that limits a…

This study looks at how type 1 diabetes affects the nerves that control the heart in children. Researchers will measure heart rate variability in 100 children with diabetes and compare them to healthy kids of the same age and sex. The goal is to find early signs of cardiac dysaut…

This study uses two special scanners (HR-pQCT and pQCT) to take detailed pictures of bone and muscle in 1,000 people with conditions that raise the risk of bone loss, like osteoporosis, arthritis, or kidney disease. The goal is to see if these scanners can spot tiny changes in bo…

This study looks at skin damage caused by D-Penicillamine, a common treatment for Wilson's disease. Researchers will measure skin elasticity in 120 participants, including patients and healthy volunteers, using silicone molds and laser analysis. The goal is to better understand h…

This study tests a program called PRESTO that aims to identify and treat first-episode psychosis sooner. The program educates the public, trains frontline workers like doctors and teachers, and provides a mobile team to connect patients to care. Researchers will measure whether t…