Centre Hospitalier Universitaire De Saint Etienne

This study is testing whether using special monitors to guide the doses of anesthesia drugs during surgery can help prevent serious complications afterward. It will involve over 1,100 elderly patients who are at high risk for problems like kidney failure, heart issues, or deliriu…

This study is testing a program designed to help prostate cancer patients start and maintain regular physical activity. It combines personalized exercise plans, support from trained health professionals, and motivational coaching from fellow patients who have successfully stayed …

This study is for people with rheumatoid arthritis who are doing well on their medication and want to see if they can safely take less of it. Researchers will check the level of the drug in the blood to create a personalized plan for slowly reducing the dose. The goal is to help …

This study compares two surgical approaches for removing large, non-cancerous uteri: traditional laparoscopic surgery versus a newer vaginal endoscopic technique called vNOTES. Researchers aim to determine which method results in fewer complications during and after surgery. The …

This study is testing whether the drug rituximab can help control a rare and disabling nerve disease called Anti-MAG neuropathy. It will enroll 90 patients who have had the disease for a short time and have high levels of a specific antibody, as these patients are thought to be m…

This study aims to find the best next step for Crohn's disease patients whose current medication (adalimumab) stops working effectively, even though drug levels in their blood remain adequate. Researchers will compare two approaches: switching to a different type of medication (v…

This study tests a new protocol to reduce the number of false and unnecessary alarms in hospital intensive care units (ICUs). It aims to see if cutting down on alarm noise improves patient comfort and safety by preventing 'alarm fatigue' in nurses. The research will measure noise…

This study is testing a new way for nurses to work with patients who have long-term health conditions like diabetes, heart disease, or Parkinson's. The goal is to see if a partnership-focused approach helps patients feel more in control of their health and improves their quality …

This study is testing a new program designed to help people experiencing their first psychotic episode get specialized psychiatric care much sooner. It aims to see if educating the public and training frontline workers like doctors and teachers to spot early signs can reduce the …

This study is testing whether a personalized exercise program combined with specific nutrition guidance can help women with constitutional thinness gain healthy muscle mass. Researchers will work with 62 women who have stable, naturally low body weight but struggle to gain weight…

This study aims to find a specific pattern of proteins in the blood that could help doctors diagnose a rare but serious lung disease called chronic thromboembolic pulmonary hypertension (CTEPH). Researchers will enroll 120 patients who are already scheduled for a heart catheteriz…

This study is creating and testing a short questionnaire to help doctors quickly screen for anxiety and depression in children and young adults who have survived childhood cancer. The goal is to make it easier to identify those who might need more support during their regular fol…

This study is testing whether a simple, non-invasive vibration device applied to the leg muscles can help prevent the loss of strength and muscle control that happens when a leg is immobilized. Researchers will have healthy volunteers wear a device that keeps one leg inactive for…

This small pilot study is testing whether physical activity done outdoors in green spaces is more helpful for reducing certain persistent symptoms of schizophrenia than the same activity done indoors. It will involve 45 adults with schizophrenia who have these specific symptoms. …

This study is testing whether a personalized 6-month support program can help older adults feel stronger and recover better from surgery for bladder or kidney cancer. The program includes tailored exercise sessions and educational workshops, starting before surgery and continuing…

This study tests whether magnetic stimulation of the brain can reduce chronic nerve pain in cancer patients. Sixty participants with pain that hasn't responded well to medications will receive either real or placebo brain stimulation sessions. Researchers will compare pain relief…

This study is testing if playing familiar music for people with Alzheimer's disease can help them fall asleep easier and be less agitated during the day. It involves 120 residents in specialized care homes, where caregivers will play music after meals. Researchers will use wrist-…

This study is testing whether adding a foam pad to a standard lower back support belt makes it more comfortable to wear. Researchers are enrolling 15 healthy volunteers to try the belt with and without the extra pad. They will rate their comfort and use special scans to see if th…

This study is testing whether adding a muscle vibration therapy to standard rehabilitation helps people recover walking ability after a recent stroke. Researchers will compare a group receiving real vibrations on their ankle muscles to a group receiving fake vibrations. The main …

This study aims to identify patients experiencing their first psychotic episode who are unlikely to respond to standard treatments. Researchers will use brain imaging scans from 80 participants to find markers that predict poor treatment response at three months. The goal is to h…

This study aims to understand how the time of day you exercise affects your deep sleep and body temperature. It will compare morning workouts to late afternoon workouts in two groups: endurance athletes and inactive people. Researchers want to see if afternoon exercise raises bod…

This study aims to understand how stroke patients with limb weakness process different types of feedback during mental movement exercises. Researchers will measure brain activity in 38 participants as they imagine moving while receiving visual cues, body-position cues, or a mix o…

This study aims to better understand skin damage that can occur in Wilson's disease patients taking the standard medication D-Penicillamine. Researchers will compare skin elasticity in 120 participants—both patients on the medication and healthy volunteers—using silicone molds an…

This study compares how well a common blood thinner (apixaban) prevents blood clots in two groups: patients newly diagnosed with multiple myeloma (a blood cancer) and patients undergoing total knee replacement surgery. Researchers want to understand if the medication works differ…

This study aims to understand how type 1 diabetes affects the nervous system's control of the heart in children. Researchers will compare 24-hour heart rate patterns in 100 children with diabetes against healthy children of the same age and sex. The goal is to see if longer diabe…

This study aims to understand if newer, more detailed bone scans can better predict who is at risk for fractures compared to standard scans. It will enroll 1000 people with conditions that weaken bones, like osteoporosis, arthritis, kidney disease, and Parkinson's, as well as a c…

This study is looking for a better way to predict which cancer patients might have serious bleeding while taking blood thinners for a clot. Researchers will measure a specific blood test (thrombin generation) in 212 patients with cancer and a recent blood clot. They will see if t…