New hope for rare nerve disease: rituximab trial targets good responders
NCT ID NCT05136976
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 3 trial tests whether the drug rituximab can improve disability in people with anti-MAG neuropathy, a rare nerve condition that causes progressive weakness and numbness. The study will enroll 90 participants who have had the disease for 5 years or less and have shown recent worsening. Participants receive two infusions of rituximab or a placebo, and researchers measure changes in daily function after 12 months.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Rituximab (Mabthera) infusion
- What this could lead to
- If it works, this could provide an effective treatment for anti-MAG neuropathy, a rare nerve disease with no proven therapy.
- What could go wrong
- Two previous trials of rituximab for this condition failed to show benefit. This trial selects patients with specific characteristics that may improve chances, but success is not guaranteed.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for ANTI MAG NEUROPATHY are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
-
APHP - Kremlin-Bicêtre
RECRUITINGParis, 94270, France
Contact
-
APHP Pitié Salpêtrière
RECRUITINGParis, 75651, France
Contact
-
CHU Brest - La cavale blanche
RECRUITINGBrest, 29200, France
Contact
-
CHU Grenoble - La tronche
RECRUITINGGrenoble, 38700, France
Contact
-
CHU La Timone - APHM
RECRUITINGMarseille, 13915, France
Contact
-
CHU Lille - Roger Salengro
RECRUITINGLille, 59037, France
Contact
-
CHU Limoges - Dupuytren
RECRUITINGLimoges, 87170, France
Contact
-
CHU Nancy- Hôpital central
RECRUITINGNancy, 54035, France
Contact
-
CHU Nice - Pasteur
RECRUITINGNice, 06031, France
Contact
-
CHU Strasbourg - Hautepierre
RECRUITINGStrasbourg, 67091, France
Contact
-
CHU Toulouse - Pierre-Paul Riquet
RECRUITINGToulouse, 31059, France
Contact
-
CHU Tours - Bretonneau
RECRUITINGTours, 37044, France
Contact
-
CHU de Saint-Etienne
RECRUITINGSaint-Etienne, France
Contact
-
HCL lyon
RECRUITINGLyon, 69002, France
Contact
-
Hôtel-Dieu et Hôpital GR Laënnec - CHU Nantes
RECRUITINGNantes, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
More trials for these conditions
Other studies related to the condition(s) this trial covers.