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Ultrasound probes nerve stiffness in rare nerve diseases

NCT ID NCT03397303

Knowledge-focused Sponsor: Nantes University Hospital Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 14, 2026 · Last updated Sep 15, 2026 · Updated 1 time

Summary

Researchers at Nantes University Hospital are studying whether nerves feel stiffer in people with three rare peripheral neuropathies: CIDP, CMT1a, and anti-MAG neuropathy. They use ultrasound shear wave elastography to measure nerve stiffness in 36 participants aged 18 to 65 and compare the readings with age-matched healthy controls. The goal is to see whether this non-invasive measurement can distinguish affected nerves from normal ones.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
ultrasound shear wave elastography measurements
What this could lead to
If nerve stiffness differs measurably in these conditions, doctors could gain a non-invasive way to detect and track peripheral neuropathies.
What could go wrong
This small observational study cannot prove that stiffness changes cause symptoms or that the measurement will be reliable enough for routine use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

36 people

The number who actually took part.

Started

Apr 2018

Finished

Dec 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Male or female aged 18 to 65 * Having social insurance status * Having given informed consent * Diagnostic of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), CMT1a or Anti-MAG (peak immunoglobulin M (IGm)\>15,000 BTU) Exclusion Criteria: For controls: * Person staying in a health or social facility * Person unable to understand the protocol and to respect the modalities * Person deprived of liberty * Person of legal age benefiting from a system of legal protection (guardianship, curators or safeguard of justice) * Participation in another biomedical research in progress * Diabetes, history of neuromuscular disease For CIDP: * Person staying in a health or social facility * Person unable to understand the protocol and to respect the modalities * Person deprived of liberty * Person of legal age benefiting from a system of legal protection (guardianship, curators or safeguard of justice) * Participation in another biomedical research in progress * MRC score \< 3 For Charcot-Marie-Tooth type 1 (CMT1) and anti-MAG: * Person staying in a health or social facility * Person unable to understand the protocol and to respect the modalities * Person deprived of liberty * Person of legal age benefiting from a system of legal protection (guardianship, curators or safeguard of justice) * Participation in another biomedical research in progress

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Conditions

The condition(s) this trial relates to.

Charcot-Marie-Tooth disease Charcot-Marie-Tooth disease type 1A chronic inflammatory demyelinating polyradiculoneuropathy polyneuropathy associated with IgM monoclonal gammapathy with anti-MAG

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anti-mag neuropathy Charcot-Marie-Tooth disease, type IA Chronic inflammatory demyelinating polyneuropathy

Contacts and locations

Locations

  • Univeristy of Nantes

    Nantes, 44093, France

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