Can a new antibody calm the immune attack in CIDP?

NCT ID NCT05581199

Terminated Disease control Sponsor: Immunovant Sciences GmbH Source: ClinicalTrials.gov ↗

First seen Aug 11, 2026 · Last updated Aug 12, 2026 · Updated 1 time

Summary

This trial is testing whether an experimental drug called batoclimab can help adults with active chronic inflammatory demyelinating polyneuropathy (CIDP), a condition where the immune system damages nerves, causing weakness and disability. Participants receive either batoclimab or a placebo for 12 weeks, followed by a withdrawal period to see if the drug prevents relapses. The study aims to see if batoclimab can reduce disability and improve quality of life for people with CIDP.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: batoclimab (an experimental antibody that blocks a protein to lower harmful immune activity)
What this could lead to: If successful, batoclimab could offer a new treatment option for CIDP, potentially reducing relapses and improving daily function for people with this nerve disorder.
What could go wrong: This is a phase 2b trial with a relatively small number of participants, so results may not be definitive. Batoclimab may not prove more effective than placebo, and it could carry risks such as infections or allergic reactions.

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Conditions

The condition(s) this trial relates to.

autoimmune disease chronic inflammatory demyelinating polyradiculoneuropathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC INFLAMMATORY DEMYELINATING POLYNEUROPATHY

Contacts and locations

Locations

SIte Number - 8400

Constanța, 900591, Romania
Site Number - 1602

Kansas City, Kansas, 66160, United States
Site Number - 1603

Scottsdale, Arizona, 85028, United States
Site Number - 1604

St. Petersburg, Florida, 33713, United States
Site Number - 1605

New York, New York, 10032, United States
Site Number - 1606

Houston, Texas, 77030, United States
Site Number - 1610

Charlotte, North Carolina, 28207, United States
Site Number - 1611

Nicholasville, Kentucky, 40356, United States
Site Number - 1613

Milwaukee, Wisconsin, 53226-3548, United States
Site Number - 1614

Portland, Oregon, 97239, United States
Site Number - 1617

Ormond Beach, Florida, 32174, United States
Site Number - 1620

Port Charlotte, Florida, 33952, United States
Site Number - 1621

New Haven, Connecticut, 06519, United States
Site Number - 1623

Philadelphia, Pennsylvania, 19104, United States
Site Number - 1624

Philadelphia, Pennsylvania, 19104, United States
Site Number - 1625

Aurora, Colorado, 80045, United States
Site Number - 1628

San Antonio, Texas, 78229, United States
Site Number - 1629

Orlando, Florida, 32806-5411, United States
Site Number - 1632

Seattle, Washington, 98195-0001, United States
Site Number - 1633

Rockledge, Florida, 32955, United States
Site Number - 1634

Los Angeles, California, 90033-5330, United States
Site Number - 2600

Edmonton, Alberta, T6J 1M3, Canada
Site Number - 2603

Vancouver, British Columbia, V6Z 1Y6, Canada
Site Number - 3201

Katowice, Silesian Voivodeship, 40-123, Poland
Site Number - 3202

Mazurki, Lublin Voivodeship, 20-093, Poland
Site Number - 3203

Bydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-796, Poland
Site Number - 3205

Gdansk, Pomeranian Voivodeship, 80-803, Poland
Site Number - 3206

Lublin, Lublin Voivodeship, 20-701, Poland
Site Number - 3207

Poznan, Greater Poland Voivodeship, 61-731, Poland
Site Number - 3208

Krakow, Lesser Poland Voivodeship, 30-688, Poland
Site Number - 3209

Krakow, Lesser Poland Voivodeship, 31-202, Poland
Site Number - 3210

Lublin, Lublin Voivodeship, 20-064, Poland
Site Number - 3211

Bydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-065, Poland
Site Number - 3241

Turku, Southwest Finland, 20520, Finland
Site Number - 3700

San Sebastián, Gipuzkoa, 20014, Spain
Site Number - 3701

L'Hospitalet de Llobregat, Barcelona, 08907, Spain
Site Number - 3703

Barcelona, 08025, Spain
Site Number - 3704

Sant Cugat del Vallès, Barcelona, 08190, Spain
Site Number - 3741

Lisbon, 1300-344, Portugal
Site Number - 3742

Senhora da Hora, Porto District, 4464-513, Portugal
Site Number - 3743

Almada, Setúbal District, 2805-267, Portugal
Site Number - 3744

Porto, 4099-001, Portugal
Site Number - 3745

Vila Nova de Gaia, Porto District, 4434-502, Portugal
Site Number - 4680

Leuven, Vlaams Brabant, 03000, Belgium
Site Number - 4681

Ghent, Oost-Vlaanderen, 09000, Belgium
Site Number - 4740

Copenhagen, 02100, Denmark
Site Number - 4891

Gothenburg, Västra Götaland County, 413 45, Sweden
Site Number - 6300

Pavia, 27100, Italy
Site Number - 6301

Bergamo, Lombardy, 24127, Italy
Site Number - 6302

Gussago, Brescia, 25084, Italy
Site Number - 6303

Pisa, Tuscany, 56126, Italy
Site Number - 6305

Bologna, Emilia-Romagna, 40139, Italy
Site Number - 6306

Rome, Lazio, 00189, Italy
Site Number - 6307

Milan, Lombardy, 20132, Italy
Site Number - 6308

Siena, Tuscany, 53100, Italy
Site Number - 6309

Rome, Lazio, 00133, Italy
Site Number - 6341

Pátrai, Achaïa, 265 04, Greece
Site Number - 6342

Heraklion, Irakleio, 715 00, Greece
Site Number - 6343

Alexandroupoli, Evros, 68100, Greece
Site Number - 6344

Athens, Attica, 115 25, Greece
Site Number - 6345

Athens, Attica, 115 28, Greece
Site Number - 6346

Ioannina, 455 00, Greece
Site Number - 6347

Larissa, 41110, Greece
Site Number - 6491

Oslo, 00424, Norway
Site Number - 6702

Leipzig, Saxony, 04103, Germany
Site Number - 6705

Bochum, North Rhine-Westphalia, 44791, Germany
Site Number - 6706

Berlin, 10117, Germany
Site Number - 7400

Manchester, M6 8HD, United Kingdom
Site Number - 7401

Sheffield, South Yorkshire, S10 2JF, United Kingdom
Site Number - 7402

Southampton, Hampshire, SO16 6YD, United Kingdom
Site Number - 7403

Preston, Lancashire, PR2 9HT, United Kingdom
Site Number - 7404

Glasgow, Lanarkshire, G51 4TF, United Kingdom
Site Number - 7405

Cambridge, Cambridgeshire, CB2 0QQ, United Kingdom
Site Number - 7750

Buenos Aires, C1199ABB, Argentina
Site Number - 7751

Rosario, Santa Fe Province, S2000DTP, Argentina
Site Number - 7752

San Miguel de Tucumán, Tucumán Province, T4000AXL, Argentina
Site Number - 7753

Rosario, Santa Fe Province, S2000BZL, Argentina
Site Number - 8401

Târgu Mureş, Mureș County, 540136, Romania
Site Number - 8403

Timișoara, Timiș County, 300736, Romania
Site Number - 8406

Bucharest, Bucharest, 41914, Romania
Site Number - 8500

Niš, 18000, Serbia
Site Number - 8501

Belgrade, 11000, Serbia
Site Number - 8502

Belgrade, 11000, Serbia
Site Number - 8503

Novi Sad, 21000, Serbia
Site Number - 8600

Liptovský Mikuláš, 031 23, Slovakia
Site Number - 8601

Martin, 036 01, Slovakia
Site Number - 8602

Trnava, 91775, Slovakia
Site Number - 8603

Prešov, 081 81, Slovakia
Site Number - 9100

Ribeirão Preto, São Paulo, 14048-900, Brazil
Site Number - 9101

Curitiba, Paraná, 81210-310, Brazil
Site Number - 9103

Brasília, Federal District, 70200-730, Brazil
Site Number - 9105

São Paulo, 01409-000, Brazil
Site Number - 9110

Sofia, Sofia-Grad, 01606, Bulgaria
Site Number - 9111

Sofia, Sofia-Grad, 01527, Bulgaria
Site Number - 9112

Pleven, 05800, Bulgaria
Site Number - 9900

Seoul, 06351, South Korea
Site Number - 9901

Seoul, 02841, South Korea
Site Number -1601

Austin, Texas, 78759, United States

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