Centre Hospitalier Universitaire De Saint Etienne

This study aims to find the best way to dose the antibiotic ceftazidime for critically ill patients in the ICU with severe infections like sepsis. It will compare a standard dosing method against a new, personalized approach that adjusts the dose based on each patient's body. The…

This study aims to see if giving a 20-strain pneumonia vaccine to adults while they have a fever works just as well and is as safe as giving it a month after the fever is gone. It will involve over 1,000 adults who are at higher risk for serious pneumococcal infections and are ho…

This study aims to see if adding mind-body therapies like hypnosis and relaxation to standard psychological care helps reduce anxiety in children, teens, and young adults who have survived cancer. It will involve 558 participants aged 7 to 25 who are in remission but experience a…

This study aims to see if evening music sessions led by a therapist can help people with Alzheimer's disease fall asleep more easily and reduce disruptive behaviors, especially during the 'sundowning' period. It will involve 48 older adults living in secure care units. Each parti…

This study aims to design better custom shoe inserts (insoles) to reduce foot pain and improve walking for people with rheumatoid arthritis. Researchers will create a 3D computer model of each patient's foot using CT scans and walking analysis to design personalized insoles. The …

This study tests whether a 6-month sleep education program, led by workplace health nurses, can help healthcare workers who are new to 12-hour alternating day and night shifts get more and better sleep. It will involve 160 nursing assistants and measure their sleep duration, qual…

This study aims to understand why people with anorexia nervosa develop strong aversions to fatty foods. Researchers will use brain scans (fMRI) to compare how the brains of 90 women with anorexia react to smells and images of fatty foods versus how healthy women react. The goal i…

This study aims to see if a personalized, AI-driven training strategy can help trail runners improve their race performance while reducing injuries and fatigue. It will compare three types of training plans: a generic one, a personalized one, and one that adapts in real-time base…

This study aims to find the best personalized dose of a medicine called fibrinogen concentrate, which helps blood to clot. It will involve 150 adults having major heart surgery who need this medicine to control bleeding after their operation. Researchers will measure how differen…

This study aims to see if a detailed heart MRI scan can predict which patients will develop a dangerous irregular heartbeat after bypass surgery. Researchers will enroll 100 patients and use a tiny implanted monitor to track their heart rhythm for a full year after their operatio…

This study aims to find the best way to use vibration therapy to improve leg strength. Researchers will test different schedules—like a short, intense week versus a longer, spread-out month—on healthy volunteers. The goal is to gather knowledge to help design better training and …