Centre Hospitalier Universitaire De Saint Etienne

This study tests a combination of two drugs, belantamab mafodotin and mezigdomide, in 44 adults with multiple myeloma whose cancer returned after treatment with CAR-T cells or bispecific antibodies. The goal is to see if the combo can control the cancer longer. The trial starts w…

This study compares a new software, C. Santé, to the standard sleep test (polysomnography) to see if it can accurately measure sleep quality. The software uses sensors on a bed to track breathing and heart rate without disturbing sleep. If successful, it could allow people to mon…

This study looks at whether adding hypnosis or relaxation sessions to standard psychological care can lower anxiety in children, teens, and young adults who have finished treatment for pediatric cancer. About 558 participants aged 7 to 25 who are in remission and have anxiety wil…

This study tests a program that combines online educational videos with in-person exercises to help young female athletes (ages 15-22) who experience urinary incontinence during sports. The program focuses on pelvic health education and strengthening the lower back and abdominal …

This pilot study tests whether watching special videos can help people recover leg movement after a stroke. Twelve participants will use a video system that shows their good leg moving, while they try to copy the movement with their affected leg. They will do this 5 times a week …

This pilot study tests whether listening to music in the evening can help people with Alzheimer's disease or related disorders fall asleep faster and behave more calmly. Researchers will compare music therapy to audiobooks in 48 adults living in secure care units. The goal is to …

This study examines how the severity of chronic kidney disease (CKD) affects the breakdown of a protein called FGF23, which is linked to bone health, anemia, and heart problems. Researchers will measure different forms of FGF23 in blood samples from 80 men with CKD stages 3a to 5…

This study looks at 70 adults with sensory neuronopathy, a rare nerve condition that causes balance and coordination problems. Researchers will test several clinical scales over 12 months to see which one best tracks how the disease changes over time. The goal is to find a reliab…

This study explores whether using physical actions, imagined movements, or videos can improve memory in people with early-stage Alzheimer's disease. Researchers will compare recall in 80 older adults (some with Alzheimer's, some healthy) after they watch videos of daily activitie…

This study aims to understand why some patients with severe dry eye syndrome improve with autologous serum eye drops while others do not. Researchers will analyze the protein makeup of the drops from 68 participants over 6 months. The goal is to identify which proteins are linked…

This study aims to find the best dose of a clotting drug (fibrinogen) for patients after heart surgery using a heart-lung machine. Bleeding is a common complication, and current dosing is not personalized. Researchers will take blood samples from 150 adults to understand how fibr…

This study looks at whether muscle measurements from a CT scan taken when a patient is admitted to the ICU for septic shock can predict their risk of dying within 3 months after leaving the ICU. Researchers will analyze muscle size, density, and fat content from the scan and comp…

This study tests whether a 6-month sleep education program, led by an occupational health nurse, can improve sleep duration in healthcare workers who work 12-hour alternating day-night shifts. 160 nurses and nursing assistants will be enrolled. The program includes an initial sle…

This study looks at whether a special MRI scan can predict if patients will develop an irregular heartbeat (atrial fibrillation) after heart bypass surgery. About 100 adults scheduled for bypass will get an MRI before surgery and wear a heart monitor for a year. The goal is to fi…

This study aims to see if a personalized training recommendation strategy, powered by artificial intelligence, can help trail runners improve their performance and reduce injuries. About 1,200 competitive trail runners will be assigned to either a personalized adaptive plan, a st…

This study looks at how the brains of women with anorexia nervosa respond to fatty food smells and images. Researchers will use brain scans to compare their reactions to those of healthy women. The goal is to understand why fatty foods cause aversion, which could help improve fut…

This study aims to find the best way to dose the antibiotic ceftazidime for patients in intensive care with serious infections. Many ICU patients don't get enough of the drug because their bodies process it differently. The researchers will test a personalized dosing plan to keep…