New PET tracer aims to spot hidden scarring in Crohn's patients
NCT ID NCT07273188
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase study tests whether a special PET scan tracer, Ga68-FAPI-46, can detect early fibrosis (scarring) in the small bowel of people with Crohn's disease. About 45 participants will be divided into those with known strictures and those without, to compare scan results. The goal is to improve diagnosis of fibrostenosing Crohn's, which currently is hard to detect early.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Ga68-FAPI-46 (a radioactive tracer for PET scans)
- What this could lead to
- If successful, this could lead to a new way to detect early scarring in Crohn's disease, helping doctors identify and treat fibrosis before it causes blockages.
- What could go wrong
- This is a very early, small study (45 people) testing a diagnostic method, not a treatment. The tracer may not reliably distinguish early fibrosis from inflammation, and results may not apply to all patients.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Mayo Clinic
RECRUITINGRochester, Minnesota, 55905, United States
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