New antibody drug shows promise for tough ulcerative colitis cases

NCT ID NCT07080034

Recruiting now Disease control Sponsor: Biocad Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tests a new drug, BCD-261, in 198 adults with moderate to severe ulcerative colitis who haven't improved with standard treatments. Participants receive one of three doses of BCD-261 or a placebo as an injection. The goal is to see if the drug can reduce inflammation and improve symptoms, like less bleeding and fewer bowel movements.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: BCD-261 (anti-TL1A antibody)
What this could lead to: If successful, this could provide a new treatment option for people with moderate to severe ulcerative colitis who haven't responded to other therapies.
What could go wrong: This is an early Phase 2 trial with only 198 participants, so results may not apply to everyone. The drug may not work better than placebo or could have unexpected side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

ulcerative colitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ULCERATIVE COLITIS (UC)

Contacts and locations

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Locations

"South Ural State Medical University" of the Ministry of Health of the Russian Federation
RECRUITING

Chelyabinsk, 454092, Russia
Branch of the LLC "Hadassah Medical LTD"
RECRUITING

Moscow, 121205, Russia

Contact Email: •••••@•••••
Federal Siberian Scientific and Clinical Center of the Federal Medical and Biological Agency
RECRUITING

Krasnoyarsk, 660022, Russia
Federal State Educational Institution of Higher Education "First Saint Petersburg State Medical University named after Academician I.P. Pavlov" of the Ministry of Health of the Russian Federation
RECRUITING

Saint Petersburg, 197022, Russia
Federal State Educational Institution of Higher Education "North-West State Medical University named after I.I. Mechnikov" of the Ministry of Health of the Russian Federation
RECRUITING

Saint Petersburg, 191015, Russia
Federal State Educational Institution of Higher Education "Rostov State Medical University" of the Ministry of Health of the Russian Federation
RECRUITING

Rostov-on-Don, Rostov Oblast, 344022, Russia
Federal State Educational Institution of Higher Education "Rostov State Medical University" of the Ministry of Health of the Russian Federation
RECRUITING

Rostov-on-Don, Rostov Oblast, 344022, Russia
LLC "Research Center Eco-Safety"
RECRUITING

Saint Petersburg, Russia
LLC Medical Center "ASTRA"
RECRUITING

Barnaul, Altayskiy Kray, 656049, Russia

Contact Email: •••••@•••••
Llc "Novosibirsk Gastrocenter"
RECRUITING

Novosibirsk, 630007, Russia

Contact Email: •••••@•••••
Llc "Olla-Med"
RECRUITING

Moscow, 105554, Russia

Contact Email: •••••@•••••
Moscow Clinical Scientific and Practical Center named after A.S. Loginov of the Moscow City Health Department
RECRUITING

Moscow, 111123, Russia

Contact Email: •••••@•••••
Regional State Healthcare Institution "Regional Clinical Hospital"
RECRUITING

Krasnoyarsk, 660022, Russia
Republican Clinical Hospital named after G.G. Kuvatov
RECRUITING

Ufa, Bashkortostan Republic, 450005, Russia
Saint Petersburg State Healthcare Institution "City Hospital of the Holy Martyr Elizabeth"
RECRUITING

Saint Petersburg, 195257, Russia
State Autonomous Institution of Healthcare "Republican Clinical Hospital of the Ministry of Healthcare of the Republic of Tatarstan"
RECRUITING

Kazan', Tatarstan Republic, 420064, Russia
State Healthcare Institution "Primorsky Regional Clinical Hospital No. 1"
RECRUITING

Vladivostok, 690091, Russia
State Healthcare Institution Ulyanovsk Regional Clinical Hospital
RECRUITING

Ulyanovsk, 432063, Russia

Contact Email: •••••@•••••
State Healthcare Institution of the City of Moscow "V.M. Buyanov City Clinical Hospital of the Moscow City Healthcare Department"
RECRUITING

Moscow, 115516, Russia
State Institution of Healthcare of the Moscow Region "Moscow Regional Research Clinical Institute named after M.F. Vladimirsky"
RECRUITING

Moscow, 129110, Russia

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