ULCERATIVE COLITIS (UC)

This study is testing whether switching to a Mediterranean-style diet and making lifestyle changes can help young adults with Crohn's disease or ulcerative colitis. Researchers will enroll 160 participants with moderately active disease to follow the diet for four weeks while tra…

This pilot study is testing whether a daily synbiotic formula called SGR11 can help improve symptoms and gut health in people with inflammatory bowel disease (IBD). Fifty adults with mild to moderate ulcerative colitis will take the formula for 8 weeks while researchers track the…

This study is testing an oral pill called LY4268989 to see if it can help control symptoms and reduce inflammation in adults with moderate to severe ulcerative colitis. It will compare the pill to a placebo (a dummy pill) in about 1,400 participants over roughly two years. The go…

This early-stage study is testing a new cell therapy called CNK-UT009 in patients with severe inflammatory bowel disease (Crohn's or colitis) who haven't responded to multiple other treatments. The main goal is to check if the treatment is safe and determine the right dose. Resea…

This study is testing if using simple stool tests to guide treatment decisions works better than standard care for keeping ulcerative colitis (UC) under control. It will involve 240 adults with UC who are currently in remission. Researchers will compare how often patients have fl…

This study is testing a new oral medication, MB-001, for adults with moderate to severe ulcerative colitis (UC). About 100 participants will take either the drug or a placebo pill daily for 12 weeks to see if it safely reduces symptoms and intestinal inflammation. The goal is to …

This study aims to find out if elderly patients with well-controlled ulcerative colitis can safely stop taking long-term immunosuppressant drugs. It will compare what happens over two years to patients who stop these medications versus those who continue them, while all patients …

This study will monitor the safety and effectiveness of Velsipity tablets over one year in patients with moderate to severe ulcerative colitis. Researchers will track 553 patients taking the medication in real-world medical settings to identify any long-term side effects. The mai…

This small pilot study is testing if the antibiotic vancomycin, taken by mouth, can safely improve symptoms of active ulcerative colitis in adults who also have a liver disease called primary sclerosing cholangitis. Fourteen participants will take either the antibiotic or a place…

This early study aims to check if a new drug called cizutamig is safe and how it affects the immune system in people with moderate to severe ulcerative colitis. It will include 15 adults whose current treatments aren't working well enough. Researchers will monitor participants cl…

This study aims to see if a modified ultrasound method can accurately measure disease activity and severity in people with moderate-to-severe ulcerative colitis. Researchers will follow 25 patients starting a new medication for 24 weeks, comparing ultrasound results to the curren…

This study is testing if a medication called modafinil can help reduce severe, long-term fatigue in people with Crohn's disease or ulcerative colitis. It's a small, early-stage trial to see if a larger study is possible. About 70 participants will be randomly assigned to take eit…

This study aims to discover biological markers that can predict how inflammatory bowel diseases (IBD) like Crohn's and ulcerative colitis will progress and how patients will respond to treatments. It will follow 4,500 participants, including people with IBD and healthy controls, …

This study aims to learn how different diets and digital information tools affect inflammation and eating habits in people with Crohn's disease or ulcerative colitis. Researchers will compare 140 patients trying a special Nordic diet or using a digital tool against those receivin…

This study aims to understand if people with Crohn's disease or ulcerative colitis take daily Vitamin D supplements as recommended by their doctors. Researchers will follow 150 patients for one year to see how many stick with the supplement, if it improves their quality of life, …

This study aims to develop a tool to predict if inflammatory bowel disease (IBD) treatments will work for a patient. Researchers will give patients fluorescent versions of two common IBD drugs and use special cameras to see where the drugs go in the gut. The goal is to understand…

This study aims to see if data from wearable devices, grocery shopping habits, and patient surveys can be used to predict flare-ups in people with Crohn's disease or ulcerative colitis. Researchers will enroll 80 adults with IBD who are willing to use a smartphone, activity track…

Micronutrient deficiencies are common in ulcerative colitis (UC). Selenium deficiency is associated with worse disease outcomes including disease flares and need for surgery. Previous in vitro and in vivo studies demonstrated that selenium regulates colonic inflammation, and that…