ULCERATIVE COLITIS (UC)

This study looks at whether people aged 60 and older with ulcerative colitis who are in long-term remission can safely stop taking thiopurines (a type of immune-suppressing drug) and stay on just mesalazine. The goal is to see if stopping thiopurines leads to more disease flare-u…

This study compares a new strategy using stool tests to guide treatment versus usual care for people with ulcerative colitis (UC) who are in remission. About 240 adults will be randomly assigned to either the stool-test-guided approach or standard monitoring. The goal is to see i…

This early-phase study tests the safety and tolerability of a new drug, cizutamig, in 15 adults with moderate to severe ulcerative colitis. Participants must have tried other treatments without success. The goal is to see if the drug is safe enough for further testing.

This pilot study will test a new synbiotic formula (SGR11) in 50 adults with mild-to-moderate ulcerative colitis, a type of inflammatory bowel disease. Participants will take the supplement daily for 8 weeks and complete symptom questionnaires, stool tests, and blood tests to see…

This study looks at how safe and effective the drug Velsipity is when used for up to 52 weeks in people with ulcerative colitis. About 553 participants will take the 2 mg tablet as part of their regular care. The main goal is to track serious infections and other side effects, wh…

This study tests a new drug called SSGJ-627 in 288 adults with moderate to severe ulcerative colitis (UC). The goal is to see if it can safely reduce symptoms like bleeding and diarrhea. Participants must have tried other treatments without success. The drug is given in addition …

This early-phase study tests a new cell therapy called CNK-UT009 in 40 people with severe inflammatory bowel disease (Crohn's or colitis) that hasn't improved with standard treatments. The main goal is to check safety and find the best dose. Researchers will also look for early s…

This study tests whether the antibiotic vancomycin can safely improve symptoms of ulcerative colitis in adults who also have a liver condition called primary sclerosing cholangitis. Fourteen participants will take vancomycin or a placebo for 4 weeks to see if it helps and is well…

This study tests whether modafinil, a drug that promotes wakefulness, can reduce severe fatigue in people with Crohn's disease or ulcerative colitis. About 70 adults with long-term fatigue will receive either modafinil or a placebo for 12 weeks. The main goal is to see if a large…

This study looks at how fecal transplants change the gut microbiome in people with recurrent C. diff infection, ulcerative colitis, or metabolic syndrome. Researchers will analyze stool and blood samples to understand why some people respond better than others. No new treatment i…

This study aims to see if data from smartwatches and grocery shopping habits can help detect when inflammatory bowel disease (Crohn's or colitis) is getting worse. About 80 adults on standard IBD treatments will wear a smartwatch and use a loyalty card to track their daily activi…

This study tests whether two fluorescent dyes attached to common IBD drugs (adalimumab and risankizumab) can show where the drugs go in the gut. About 30 adults with ulcerative colitis or Crohn's disease will receive the dyed drugs before a routine colonoscopy. The goal is to see…

This study will test whether a modified ultrasound technique can accurately measure inflammation in people with moderate-to-severe ulcerative colitis. About 25 adults starting a new medication will get both ultrasound and colonoscopy exams over 24 weeks. If ultrasound proves reli…

This study looks at how taking vitamin D affects people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. Over 12 months, 150 adults will take 2,000 IU of vitamin D daily and complete surveys, blood tests, and stool tests. The goal is to see…

This study follows 4500 adults with Crohn's disease or ulcerative colitis to identify biological markers, especially gut bacteria, that predict disease progression and complications. Researchers will analyze stool and tissue samples alongside medical records. No new treatments ar…

This study looks at how diet affects inflammation in people with Crohn's disease or ulcerative colitis. Researchers want to see if using a stool test (calprotectin) to guide food choices reduces picky eating, and if a digital tool improves quality of life. About 140 participants …