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Scientists probe gut bacteria after fecal transplants to unlock secrets of chronic disease

NCT ID NCT06992453

Not yet recruiting Knowledge-focused Sponsor: Catholic University of the Sacred Heart Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study will give fecal transplants to 90 people with recurrent C. difficile infection, ulcerative colitis, or metabolic syndrome. Researchers will use advanced tests on stool and tissue samples to track how donor bacteria settle in the gut and interact with the host. The goal is to understand why fecal transplants work well for some conditions but not others, which could improve future treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
fecal microbiota transplantation (FMT)
What this could lead to
If successful, this could reveal why fecal transplants work for some conditions but not others, potentially leading to more effective treatments for gut-related diseases.
What could go wrong
This is an early-stage observational study, not a treatment trial. It aims to understand mechanisms, not to test a cure. Results may not lead to direct patient benefits.

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Conditions

The condition(s) this trial relates to.

abdominal obesity-metabolic syndrome Clostridium difficile colitis metabolic syndrome X ulcerative colitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

METABOLIC SYNDROME (METS) RECURRENT C. DIFFICILE (RCDI) ULCERATIVE COLITIS (UC)

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Catholic University of the Sacred Heart

    Rome, RM, 00168, Italy

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