Seaweed extract may soothe inflamed guts — trial puts it to the test
NCT ID NCT07786389
First seen Aug 26, 2026 · Last updated Aug 27, 2026 · Updated 1 time
Summary
This trial asks whether a supplement made from brown algae, called fucoidan, can improve gut health in people with mild to moderate ulcerative colitis. Participants will take fucoidan or a placebo alongside their usual medication for 12 weeks. Researchers will measure changes in gut inflammation and stool consistency to see if the supplement helps restore a healthier gut.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Low molecular weight fucoidan derived from brown algae (Turbinaria ornata), taken orally as a dietary supplement alongside standard care.
- What this could lead to
- If it works, this could point toward a natural supplement that helps calm gut inflammation and improve digestive health in people with ulcerative colitis.
- What could go wrong
- This is an early-phase trial, so the supplement may not prove effective or safe. It is tested only in mild-to-moderate cases, and results may not apply to everyone.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 1/2
Runs two stages together: safety and dose first, then whether the treatment works.
- Participants
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About 90 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Aug 2026
An estimate. Start dates often move.
- Expected to finish
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Dec 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 64 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Male and female patients aged between 18-64 years; * Active mild to moderate diagnosed cases of uc * Voluntarily agreeing to participate and providing informed consent. * Exclusion Criteria: * Other autoimmune disorders and chronic diseases. * Patient with Clotting problems. * Patients using oral/intravenous steroids, leukotriene antagonists, immunosuppressant's, systemic photo chemotherapy, immunotherapy, allergen-specific immunotherapy, or Chinese herbal medicine within one month before enrolment. * Patient unable to take the trial supplements as scheduled or cooperate in filling out the questionnaire and taking a blood test. * Patients with a history of allergy * Patients suffering from serious infection requiring hospitalization assessed by a clinician * Severe organ dysfunction (e.g., heart failure, liver failure, liver cirrhosis, or renal failure assessed by a clinician. * Pregnant women or those preparing for pregnancy, and those in lactation. * Patient with hypothyroidism. * Patients with a history of allergy to Soy. * Acute severe (fulminant) UC
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
The full official record for this study. This one lists no contact details, but it is the first place any would appear.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Allama Iqbal Medical college
Lahore, Punjab Province, 54590, Pakistan
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- Can a new pill outperform standard care for ulcerative colitis?