New antibody drug aims to tame ulcerative colitis

NCT ID NCT06619990

Recruiting now Disease control Sponsor: Xencor, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 24, 2026 · Updated 1 time

Summary

This study tests a new antibody drug called XmAb942 for moderate-to-severe ulcerative colitis, a chronic inflammatory bowel disease. First, healthy volunteers will receive the drug to check safety. Then, about 270 people with ulcerative colitis will get either XmAb942 or a placebo to see if it can reduce symptoms and inflammation. The goal is to find a new treatment that helps patients achieve remission.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: XmAb942 (an antibody)
What this could lead to: If successful, this could lead to a new treatment option for people with moderate-to-severe ulcerative colitis, potentially helping them achieve remission.
What could go wrong: This is an early trial (phase 1/2) with a small number of participants. The drug may not work as hoped, and side effects are unknown. It will take years before it might be available.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

inflammatory bowel disease ulcerative colitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ULCERATIVE COLITIS (UC)

Contacts and locations

Locations

Xencor Investigative Site
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Scottsdale, Arizona, 85255, United States
Xencor Investigative Site
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Bradenton, Florida, 34209, United States
Xencor Investigative Site
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Brandon, Florida, 33511, United States
Xencor Investigative Site
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Jacksonville, Florida, 32258, United States
Xencor Investigative Site
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Kissimmee, Florida, 34741, United States
Xencor Investigative Site
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Margate, Florida, 33063, United States
Xencor Investigative Site
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Palmetto Bay, Florida, 33176, United States
Xencor Investigative Site
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Tampa, Florida, 33612, United States
Xencor Investigative Site
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Tampa, Florida, 33613, United States
Xencor Investigative Site
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Louisville, Kentucky, 40218, United States
Xencor Investigative Site
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Oxford, Mississippi, 38655, United States
Xencor Investigative Site
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Tupelo, Mississippi, 38801, United States
Xencor Investigative Site
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Albany, New York, 12206, United States
Xencor Investigative Site
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Rochester, New York, 14618, United States
Xencor Investigative Site
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Raleigh, North Carolina, 27612, United States
Xencor Investigative Site
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Beavercreek, Ohio, 45440, United States
Xencor Investigative Site
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Cordova, Tennessee, 38018, United States
Xencor Investigative Site
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Cedar Park, Texas, 78613, United States
Xencor Investigative Site
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Denton, Texas, 76201, United States
Xencor Investigative Site
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Garland, Texas, 75044, United States
Xencor Investigative Site
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Georgetown, Texas, 78628, United States
Xencor Investigative Site
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Houston, Texas, 77024, United States
Xencor Investigative Site
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Houston, Texas, 77090, United States
Xencor Investigative Site
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Kingwood, Texas, 77339, United States
Xencor Investigative Site
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Lubbock, Texas, 79424, United States
Xencor Investigative Site
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San Antonio, Texas, 78229, United States
Xencor Investigative Site
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Tyler, Texas, 75701, United States
Xencor Investigative Site
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Webster, Texas, 77598, United States
Xencor Investigative Site
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Richmond, Virginia, 23229, United States
Xencor Investigative Site
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Buenos Aires, C425BGC, Argentina
Xencor Investigative Site
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Rosario, S2000, Argentina
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San Miguel de Tucumán, 4000, Argentina
Xencor Investigative Site
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Adelaide, 5000, Australia
Xencor Investigative Site
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Joondalup, 6027, Australia
Xencor Investigative Site
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Melbourne, 3004, Australia
Xencor Investigative Site
COMPLETED

Nedlands, 6009, Australia
Xencor Investigative Site
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South Brisbane, 4101, Australia
Xencor Investigative Site
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Southport, 4215, Australia
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Wollongong, 2500, Australia
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Campinas, 13092-133, Brazil
Xencor Investigative Site
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Porto Alegre, 90035-903, Brazil
Xencor Investigative Site
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Santo André, 09080-110, Brazil
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São Paulo, 04543-011, Brazil
Xencor Investigative Site
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Votuporanga, 15500-269, Brazil
Xencor Investigative Site
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Sofia, 1618, Bulgaria
Xencor Investigative Site
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London, N6K 1M5, Canada
Xencor Investigative Site
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Montreal, H3H 1EB, Canada
Xencor Investigative Site
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Scarborough, M1S4T7, Canada
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Vancouver, V6Z 2K5, Canada
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Osijek, 31000, Croatia
Xencor Investigative Site
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Rijeka, 51000, Croatia
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Zagreb, 10000, Croatia
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Tbilisi, 0112, Georgia
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Athens, 10676, Greece
Xencor Investigative Site
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Heraklion, 71500, Greece
Xencor Investigative Site
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Thessaloniki, 54642, Greece
Xencor Investigative Site
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Budapest, 1066, Hungary
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Budapest, 1136, Hungary
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Budapest, 1139, Hungary
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Nyíregyháza, H-4405, Hungary
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Vác, 2600, Hungary
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Chisinau, Moldova
Xencor Investigative Site
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Bydgoszcz, 85-079, Poland
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Katowice, 40-748, Poland
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Krakow, 30-363, Poland
Xencor Investigative Site
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Nowy Targ, 34-400, Poland
Xencor Investigative Site
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Sopot, 81-756, Poland
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Staszów, 28-200, Poland
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Szczecin, 71-685, Poland
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Warsaw, 00-189, Poland
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Warsaw, 004-501, Poland
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Warsaw, 03-580, Poland
Xencor Investigative Site
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Wroclaw, 52-416, Poland
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Wroclaw, 53-611, Poland
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Loures, 2674-514, Portugal
Xencor Investigative Site
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Bucharest, District 1, 01-1658, Romania
Xencor Investigative Site
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Cluj-Napoca, 400006, Romania
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Ploieşti, 100032, Romania
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Timișoara, 300002, Romania
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Ivano-Frankivsk, 76008, Ukraine
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Kyiv, 01135, Ukraine
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Kyiv, 02091, Ukraine
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Lutsk, 43005, Ukraine
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Lviv, 79000, Ukraine
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Lviv, 79010, Ukraine
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Lviv, 79059, Ukraine
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Uzhhorod, 88000, Ukraine
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Vinnytsia, 21009, Ukraine
Xencor Investigative Site
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Vinnytsia, 21028, Ukraine
Xencor Investigative Site
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Zhytomyr, 10001, Ukraine

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