Xencor, Inc.

This early-stage study tests a new drug called XmAb541 in people with advanced ovarian, endometrial, or germ cell tumors that have not responded to prior treatments. The main goals are to check if the drug is safe and to find the best dose. About 282 participants will receive the…

This early-stage study tests a new drug called XmAb657 in healthy volunteers and people with autoimmune diseases like scleroderma, Sjögren's, and inflammatory myopathies. The main goal is to see if the drug is safe and tolerable when given as an injection under the skin. Up to 60…

This early-phase study tests a new drug called XmAb819 in people with advanced clear cell kidney cancer that has come back or stopped responding to standard treatments. The main goal is to check the drug's safety and find the best dose. About 307 participants will receive the dru…

This study tests a new drug called XmAb942 for people with moderate-to-severe ulcerative colitis, a condition that causes inflammation and sores in the colon. First, healthy volunteers will help check the drug's safety. Then, about 270 people with ulcerative colitis will receive …

This early-stage study tests a new drug called plamotamab in 68 adults with moderate to severe rheumatoid arthritis who have not responded well to other treatments. The main goal is to check the drug's safety and side effects when given as an injection under the skin. Researchers…