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New hope for kidney cancer: experimental drug XmAb819 enters human trials

NCT ID NCT05433142

Recruiting now Disease control Sponsor: Xencor, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-stage study tests a new drug called XmAb819 in people with advanced clear cell kidney cancer that has come back or not responded to standard treatments. The main goal is to check the drug's safety and find the best dose. About 307 participants will receive the drug intravenously or as a shot under the skin.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

colonic neoplasm kidney cancer lung neoplasm nonpapillary renal cell carcinoma renal cell carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CLEAR CELL RENAL CELL CARCINOMA

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

  • Contact

    Email: •••••@•••••

Locations

  • Xencor Investigative Site

    RECRUITING

    Phoenix, Arizona, 85054, United States

  • Xencor Investigative Site

    RECRUITING

    Duarte, California, 91010, United States

  • Xencor Investigative Site

    RECRUITING

    Sacramento, California, 95817, United States

  • Xencor Investigative Site

    RECRUITING

    New Haven, Connecticut, 06520, United States

  • Xencor Investigative Site

    RECRUITING

    Jacksonville, Florida, 32224, United States

  • Xencor Investigative Site

    RECRUITING

    Atlanta, Georgia, 30322, United States

  • Xencor Investigative Site

    RECRUITING

    Chicago, Illinois, 60611, United States

  • Xencor Investigative Site

    RECRUITING

    Chicago, Illinois, 60637, United States

  • Xencor Investigative Site

    RECRUITING

    Louisville, Kentucky, 40207, United States

  • Xencor Investigative Site

    RECRUITING

    Rochester, Minnesota, 55905, United States

  • Xencor Investigative Site

    RECRUITING

    New Brunswick, New Jersey, 088901, United States

  • Xencor Investigative Site

    RECRUITING

    New York, New York, 10032, United States

  • Xencor Investigative Site

    RECRUITING

    New York, New York, 10065, United States

  • Xencor Investigative Site

    RECRUITING

    Charlotte, North Carolina, 28777, United States

  • Xencor Investigative Site

    RECRUITING

    Durham, North Carolina, 27710, United States

  • Xencor Investigative Site

    RECRUITING

    Cincinnati, Ohio, 45267, United States

  • Xencor Investigative Site

    RECRUITING

    Columbus, Ohio, 43210, United States

  • Xencor Investigative Site

    RECRUITING

    Oklahoma City, Oklahoma, 73104, United States

  • Xencor Investigative Site

    RECRUITING

    Nashville, Tennessee, 37203, United States

  • Xencor Investigative Site

    RECRUITING

    Seattle, Washington, 98109, United States

  • Xencor Investigative Site

    RECRUITING

    Leuven, 3000, Belgium

  • Xencor Investigative Site

    RECRUITING

    Bourdeaux, 33075, France

  • Xencor Investigative Site

    RECRUITING

    Villejuif, 94805, France

  • Xencor Investigative Site

    RECRUITING

    Barcelona, 08035, Spain

  • Xencor Investigative Site

    RECRUITING

    Madrid, 28050, Spain

  • Xencor Investigative Site

    RECRUITING

    Cambridge, Cambridgeshire, CB2 0QQ, United Kingdom