Could less be more? study tests cutting biologic doses for Crohn's and colitis

NCT ID NCT07303686

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing whether people with Crohn's disease or ulcerative colitis who are in deep remission can safely reduce their dose of the biologic drug ustekinumab. Participants will either switch from injections every 4 weeks to every 8 weeks, or from every 8 weeks to every 12 weeks. Researchers will monitor blood levels, inflammation markers, and gut health to see if remission holds. The goal is to find out if lower doses can still keep the disease under control.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
ustekinumab
What this could lead to
If successful, this could show that some patients with Crohn's disease or ulcerative colitis can safely take less medication while staying well, reducing treatment burden and side effects.
What could go wrong
This is a small pilot study, so results may not apply to everyone. Reducing the dose could cause the disease to flare up again, and the study does not yet prove long-term safety.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • MUHC - Montreal General Hospital

    RECRUITING

    Montreal, Quebec, H3G1A4, Canada

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