CROHN DISEASE (CD)

This phase 2 trial tests whether infusions of donor stem cells can improve symptoms of Crohn's disease compared to a placebo. 46 adults with Crohn's will receive either stem cells or a placebo over 16 weeks, then be followed for a year. The main goal is to see if the treatment re…

This study looks at whether people with Crohn's disease or ulcerative colitis who are in deep remission can safely reduce how often they take the biologic drug ustekinumab. Researchers will monitor blood levels, inflammation, and gut health to see if a lower dose still keeps the …

This study looks at whether switching to a drug called guselkumab (Tremfya) can help people with inflammatory bowel disease (IBD) who did not get enough relief from ustekinumab. About 200 adults across Canada will take guselkumab for one year, and doctors will track their symptom…

This study looks at whether adding a special diet called the Crohn's Disease Exclusion Diet (CDED) to the standard anti-TNF medicine (infliximab) helps children with Crohn's disease feel better and have fewer flare-ups. About 140 children starting infliximab will be randomly assi…

This study is testing whether a smartphone app called SMART-IBD can help teenagers (ages 13-17) with inflammatory bowel disease (IBD) take their medications as prescribed and improve their self-management skills. The app includes daily symptom diaries, medication reminders, educa…

This large study will follow about 4,000 people who have had a fecal microbiota transplant (FMT) to see how well it works over time and if it's safe. FMT involves putting healthy donor stool into a patient's gut to restore good bacteria. The study looks at conditions like severe …

This study tests whether adding a low-dose of upadacitinib to a standard TNF inhibitor works better than increasing the TNF inhibitor dose alone for people with moderate-to-severe Crohn's disease who aren't getting enough relief. About 312 adults will be randomly assigned to one …

This study tests a new surgical approach for people with Crohn's disease affecting the last part of the small intestine. The surgery removes the diseased section and a portion of the nearby mesentery (fatty tissue), then reconnects the bowel using a special technique called Kono-…

This study tests whether adding a special diet (Crohn's Disease Exclusion Diet) to standard anti-TNF medication helps people with active Crohn's disease or ulcerative colitis feel better faster. About 80 adults starting anti-TNF therapy will be randomly assigned to either receive…

This study tests a new strategy to prevent Crohn's disease from returning after bowel surgery. By measuring a protein in stool (fecal calprotectin) three months after surgery, doctors can decide earlier whether to adjust treatment. The goal is to reduce the number of patients who…

This study tests whether an oral treatment called EXL01 can prevent Crohn's disease from returning after bowel surgery. About 80 adults who recently had surgery for Crohn's will take either EXL01 or a placebo daily for up to 24 weeks. Doctors will use a camera to check the bowel …

This study tests whether a short educational video, along with handouts, can help children and teens with inflammatory bowel disease (IBD) eat fewer ultra-processed foods like packaged snacks and sugary drinks. About 120 participants will track their eating online and receive eit…

This early-phase study tests whether a daily cranberry supplement can help rebalance gut bacteria in 50 adults with Crohn's disease. Participants take either the supplement or a placebo for 10 weeks, providing blood, urine, and stool samples. The goal is to see if cranberry compo…

This study compares two ways of selecting biologic treatment for adults with active Crohn's disease: using a new epigenetic test (EpiPredict) versus the usual standard of care. About 378 participants will be randomly assigned to either approach. The goal is to see if the test lea…

This study compares using plain water versus the usual polyethylene glycol (PEG) solution as a bowel preparation for MRI scans in people with Crohn's disease. About 194 participants will be randomly assigned to drink either water or PEG before their scan. The goal is to see if wa…

This study is a large registry that will follow 10,000 people with inflammatory bowel disease (Crohn's disease, ulcerative colitis, or indeterminate colitis) in Germany. The goal is to collect real-world information on how the disease behaves, how well treatments work, and what c…

This study looks at whether ultrasound can be used instead of CT scans to check for muscle loss (sarcopenia) in people with inflammatory bowel disease (IBD). CT scans are the current gold standard but involve radiation and are not always easy to get. The study will compare ultras…