CROHN DISEASE (CD)

This study is testing whether a smartphone app called SMART-IBD can help teenagers with inflammatory bowel disease (IBD) stick to their medication schedules and manage their symptoms better. Researchers will compare 35 teens using the app—which includes medication reminders, symp…

This study is testing whether simple nutrition education can help children and teens with inflammatory bowel disease (IBD) eat fewer ultra-processed foods like chips, soda, and fast food. About 120 young patients will track their eating and receive either educational handouts or …

This study is testing a new strategy to prevent Crohn's disease from returning after intestinal surgery. It involves checking a simple stool test 3 months after surgery and starting stronger medication right away if the test suggests inflammation, instead of waiting 6 months. The…

This study is testing if a new blood test that analyzes epigenetic markers can help doctors choose the most effective biologic drug for adults with active Crohn's disease. About 378 participants will be randomly assigned to have their treatment selected either by this new test or…

This large observational study follows 4,000 patients who received fecal microbiota transplantation (FMT) to treat various gut conditions and autism. Researchers will track how well the treatment works and monitor safety over 1 to 5 years after the procedure. The goal is to under…

This study is testing a new surgical technique for people with Crohn's disease in the last part of the small intestine who need an operation. The technique combines two newer methods to see if it is safe and if it can lower the chance of the disease returning after surgery. Resea…

This study is testing if a medication called guselkumab can help people with Crohn's disease or ulcerative colitis who still have active symptoms despite taking ustekinumab. About 200 adults in Canada will switch to guselkumab and be monitored for one year to see if their symptom…

This study is testing whether patients with Crohn's disease or ulcerative colitis who are in deep remission can safely reduce the frequency of their ustekinumab injections. Researchers want to see if patients can space out their shots from every 4 weeks to every 8 weeks, or from …

This study is testing whether following a specific diet plan, called the Crohn's Disease Exclusion Diet (CDED), can make standard biologic medications more effective for people with active Crohn's disease or ulcerative colitis. It will compare two groups of about 80 adults: one g…

This study is observing how well the medication risankizumab (SKYRIZI) heals the full thickness of the bowel wall in adults with Crohn's disease. Researchers will use intestinal ultrasound scans, which are easier for patients than repeated colonoscopies, to measure healing at 4 a…

This study is testing whether infusions of donor stem cells can help control Crohn's disease. It will compare the stem cell treatment against a placebo in 46 adults with active Crohn's symptoms. The main goal is to see if the treatment safely reduces disease activity and gut infl…

This study is testing whether a daily cranberry supplement can help improve gut health for people with Crohn's disease. Researchers want to see if the supplement can help balance gut bacteria and reduce inflammation. Over 10 weeks, 50 adults with Crohn's will take either the cran…

This study is testing whether an oral medication called EXL01 can prevent Crohn's disease from flaring up again after patients have surgery to remove damaged intestine. About 80 adults who recently had surgery will take either EXL01 or a placebo pill for 24 weeks. Researchers wil…

This study aims to find out what normal levels of a gut inflammation protein called calprotectin look like in healthy adults. About 120 healthy volunteers aged 22+ will mail in one stool sample from home using a provided kit. The results will help doctors better interpret test re…

This study aims to see if a simple, radiation-free ultrasound scan can reliably measure muscle loss in people with Crohn's disease. Researchers will compare ultrasound measurements of arm, leg, and stomach muscles to the current 'gold standard' CT scan in 100 adult patients. The …

This study is creating a large national registry to track inflammatory bowel disease (IBD) patients in Germany over time. It aims to understand how patients are treated in everyday practice, how well treatments work, and how the disease affects quality of life. The goal is to gat…