New drug aims to prevent Crohn's relapse after surgery

NCT ID NCT06925061

Recruiting now Prevention Sponsor: Madeleine Bezault Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tests an oral drug called EXL01 to see if it can prevent Crohn's disease from coming back after bowel surgery. About 80 adults who recently had surgery for Crohn's will receive either EXL01 or a placebo for up to 24 weeks. Doctors will use a camera to check the bowel for signs of disease at 6 months after surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: EXL01 (an oral drug)
What this could lead to: If it works, this could point toward a new way to prevent Crohn's disease from coming back after surgery.
What could go wrong: This is an early Phase 2 trial with only 80 people, so results may not apply to everyone. The drug may not work better than placebo, and side effects are still being studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for CROHN DISEASE (CD) are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

Crohn disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CROHN DISEASE (CD)

Contacts and locations

Locations

CHU Clermont-Ferrand
RECRUITING

Clermont-Ferrand, France
CHU Lille
RECRUITING

Lille, France
CHU Marseille Nord
RECRUITING

Marseille, France
CHU Montpellier
RECRUITING

Montpellier, France
CHU Nancy
RECRUITING

Nancy, France
CHU Nantes
RECRUITING

Nantes, France
CHU Nice Archet 2
RECRUITING

Nice, France
CHU Saint Louis
RECRUITING

Paris, 75010, France
Hospices civils Lyon Sud
RECRUITING

Lyon, France
Hôpital Bicêtre
RECRUITING

Le Kremlin-Bicêtre, 94270, France
Hôpital Henri Mondor
RECRUITING

Créteil, France
Hôpital Saint Antoine
RECRUITING

Paris, 75012, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.